We are analyzing https://link.springer.com/article/10.1007/s00018-013-1277-5.

Title:
Neurovascular development and links to disease | Cellular and Molecular Life Sciences
Description:
The developing central nervous system (CNS) is vascularized via ingression of blood vessels from the outside as the neural tissue expands. This angiogenic process occurs without perturbing CNS architecture due to exquisite cross-talk between the neural compartment and invading blood vessels. Subsequently, this intimate relationship also promotes the formation of the neurovascular unit that underlies the blood–brain barrier and regulates blood flow to match brain activity. This review provides a historical perspective on research into CNS blood vessel growth and patterning, discusses current models used to study CNS angiogenesis, and provides an overview of the cellular and molecular mechanisms that promote blood vessel growth and maturation. Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, pubmed, cas, vascular, endothelial, cell, cells, cns, vegf, development, blood, vessel, angiogenesis, signaling, vessels, retinal, vascularization, brain, neural, neurovascular, growth, mouse, retina, tip, nrp, hindbrain, vasculature, biol, formation, tube, dev, sprouting, studies, ingression, plexus, cellular, developing, embryonic, neuropilin, receptor, system, angiogenic, mechanisms, reviewed, vegfa, expression, essential, ruhrberg, cerebral,

Topics {✒️}

canonical wnt/β-catenin pathway tumor-initiating stem/progenitor cell vegf-a-induced dll4 expression csf1 op/op mutants astrocyte-expressed integrin alpha article download pdf wnt/β-catenin signaling wnt/beta-catenin signaling mesoderm-derived cells proliferate arterial-venous network formation extra-retinal vascular systems protein-coupled receptor gpr124 neuronal apoptosis induced blood–brain barrier integrity tumor-derived vascular cells contra-lateral side serving function-blocking antibody revealed tgfβ type ii receptor extracellular matrix-bound vegf neuron-astrocyte interaction tyrosine kinase flk1 notch-dependent vegfr3 upregulation neuronal activity stimulates context-dependent proangiogenic function heparin-binding vegf hypoxia-induced neovascularization tip cell induction transforming growth factor fibroblast growth factor-2 neuropilin-1 regulates attachment vascular permeability factor regulates blood flow sema3e/plexind1 signaling initial vascular growth regulate tip cell astrocyte-derived vegf privacy choices/manage cookies l1 signaling pathways β-catenin resulted cerebral cavernous malformations tip cell behavior specific cell type blood vessel growth endothelial cell behavior distinct endothelial lineages neighboring vessel sprouts plexin-nrp1 complexes [76] protein-coupled receptor �normalizes” tumor vessels candidate vascular growth

Questions {❓}

Schwarz Q, Ruhrberg C (2010) Neuropilin, you gotta let me know: should I stay or should I go?

Schema {🗺️}

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         headline:Neurovascular development and links to disease
         description:The developing central nervous system (CNS) is vascularized via ingression of blood vessels from the outside as the neural tissue expands. This angiogenic process occurs without perturbing CNS architecture due to exquisite cross-talk between the neural compartment and invading blood vessels. Subsequently, this intimate relationship also promotes the formation of the neurovascular unit that underlies the blood–brain barrier and regulates blood flow to match brain activity. This review provides a historical perspective on research into CNS blood vessel growth and patterning, discusses current models used to study CNS angiogenesis, and provides an overview of the cellular and molecular mechanisms that promote blood vessel growth and maturation. Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease.
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      headline:Neurovascular development and links to disease
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         Neural tube
         Retina
         Hindbrain
         VEGF
         Semaphorins
         Neuropilin
         GPCR124
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         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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               type:PostalAddress
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            address:
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               type:PostalAddress
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      name:Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, USA

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