We are analyzing https://link.springer.com/article/10.1007/bf03341829.

Title:
Myocardial injury after hypoxia in immature, adult and aged rats | Aging Clinical and Experimental Research
Description:
We evaluated the abilities of isolated perfused hearts from immature (IM) (2.5–3 months), ADULT (11–13 months) and OLD (24–26 months) Fischer 344 rats to tolerate and recover from oxygen deprivation. Hearts were perfused at 60 mmHg for a 30-minute prehypoxic period with oxygenated buffer supplemented with 10 mM glucose (+insulin) and 2 mM acetate, then 30 minutes with substrate-free, hypoxic buffer gassed with 95% N2:5% CO2, and finally reoxygenated for an additional 45 minutes with the same buffer used during the prehypoxic period. During prehypoxia, all groups were similar in ventricular mechanical function, glycogen content, high-energy phosphates (HEP), reduced glutathione (GSH), Ca++ content, and mitochondrial state 3 rates. At the end of the hypoxic period, glycogen levels were similar and almost completely depleted in all groups, HEP were lower (p<0.05) in ADULT vs other groups, mitochondrial state 3 rates were decreased (24%, p<0.05) only in ADULT, and GSH was depleted by 34% in IM vs only 13% in OLD (p<0.05). After 45 minutes of reoxygenation, IM and OLD had recovered 48% and 45% of their respective prehypoxic function which was two-fold greater than the 23% recovery by ADULT. Loss of cytosolic enzymes, an indicator of sarcolemmal damage, was estimated by measuring lactate dehydrogenase (LDH) release. LDH release and Ca++ content during reoxygenation in IM were only about half of that observed in ADULT or OLD. We conclude that immature and aged hearts tolerate and recover from hypoxia better than hearts from adults, and that the sarcolemmal membranes of immature rat hearts are less susceptible to damage from hypoxic stress than those of either older group.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Social Networks
Health & Fitness
Fitness & Wellness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

article, google, scholar, cas, pubmed, physiol, adult, content, aging, rats, starnes, hearts, rat, heart, immature, injury, aged, privacy, cookies, function, research, myocardial, hypoxia, isolated, cardiac, publish, search, seiler, state, stress, access, agerelated, res, myocardium, data, information, log, journal, bowles, perfused, months, fischer, oxygen, prehypoxic, period, buffer, minutes, hypoxic, groups, similar,

Topics {✒️}

month download article/chapter article aging clinical experimental research aims full article pdf privacy choices/manage cookies post-ischemic reperfusion isolated rat heart age-related incidence cardiac mitochondria hypothermic ischemic arrest european economic area scope submit manuscript ventricular mechanical function high-energy phosphates measuring lactate dehydrogenase chronic alcohol intoxication 31p-mrs study isolated perfused hearts food restricted rats conditions privacy policy ageing dev small tissue samples perfused rat heart aged rat hearts oxygenated buffer supplemented glutathione mixed disulfides related subjects newborn rat hearts accepting optional cookies 30-minute prehypoxic period cardiac energetics article starnes hypoxic buffer gassed respective prehypoxic function aged hearts tolerate calcium mediated damage main content log journal finder publish check access seiler rights instant access age-related immature rat hearts article log isolated hearts aged rats immature myocardial tolerance hypoxic stress article cite rabbit heart

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Myocardial injury after hypoxia in immature, adult and aged rats
         description:We evaluated the abilities of isolated perfused hearts from immature (IM) (2.5–3 months), ADULT (11–13 months) and OLD (24–26 months) Fischer 344 rats to tolerate and recover from oxygen deprivation. Hearts were perfused at 60 mmHg for a 30-minute prehypoxic period with oxygenated buffer supplemented with 10 mM glucose (+insulin) and 2 mM acetate, then 30 minutes with substrate-free, hypoxic buffer gassed with 95% N2:5% CO2, and finally reoxygenated for an additional 45 minutes with the same buffer used during the prehypoxic period. During prehypoxia, all groups were similar in ventricular mechanical function, glycogen content, high-energy phosphates (HEP), reduced glutathione (GSH), Ca++ content, and mitochondrial state 3 rates. At the end of the hypoxic period, glycogen levels were similar and almost completely depleted in all groups, HEP were lower (p<0.05) in ADULT vs other groups, mitochondrial state 3 rates were decreased (24%, p<0.05) only in ADULT, and GSH was depleted by 34% in IM vs only 13% in OLD (p<0.05). After 45 minutes of reoxygenation, IM and OLD had recovered 48% and 45% of their respective prehypoxic function which was two-fold greater than the 23% recovery by ADULT. Loss of cytosolic enzymes, an indicator of sarcolemmal damage, was estimated by measuring lactate dehydrogenase (LDH) release. LDH release and Ca++ content during reoxygenation in IM were only about half of that observed in ADULT or OLD. We conclude that immature and aged hearts tolerate and recover from hypoxia better than hearts from adults, and that the sarcolemmal membranes of immature rat hearts are less susceptible to damage from hypoxic stress than those of either older group.
         datePublished:2014-01-18T00:00:00Z
         dateModified:2014-01-18T00:00:00Z
         pageStart:268
         pageEnd:276
         sameAs:https://doi.org/10.1007/BF03341829
         keywords:
            Aging
            isolated heart
            oxidative stress
            reperfusion
            Geriatrics/Gerontology
         image:
         isPartOf:
            name:Aging Clinical and Experimental Research
            issn:
               1720-8319
               1594-0667
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:J. W. Starnes
               affiliation:
                     name:University of Texas at Austin
                     address:
                        name:Department of Kinesiology, University of Texas at Austin, Austin, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:D. K. Bowles
               affiliation:
                     name:University of Texas at Austin
                     address:
                        name:Department of Kinesiology, University of Texas at Austin, Austin, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:K. S. Seiler
               affiliation:
                     name:University of Texas at Austin
                     address:
                        name:Department of Kinesiology, University of Texas at Austin, Austin, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Myocardial injury after hypoxia in immature, adult and aged rats
      description:We evaluated the abilities of isolated perfused hearts from immature (IM) (2.5–3 months), ADULT (11–13 months) and OLD (24–26 months) Fischer 344 rats to tolerate and recover from oxygen deprivation. Hearts were perfused at 60 mmHg for a 30-minute prehypoxic period with oxygenated buffer supplemented with 10 mM glucose (+insulin) and 2 mM acetate, then 30 minutes with substrate-free, hypoxic buffer gassed with 95% N2:5% CO2, and finally reoxygenated for an additional 45 minutes with the same buffer used during the prehypoxic period. During prehypoxia, all groups were similar in ventricular mechanical function, glycogen content, high-energy phosphates (HEP), reduced glutathione (GSH), Ca++ content, and mitochondrial state 3 rates. At the end of the hypoxic period, glycogen levels were similar and almost completely depleted in all groups, HEP were lower (p<0.05) in ADULT vs other groups, mitochondrial state 3 rates were decreased (24%, p<0.05) only in ADULT, and GSH was depleted by 34% in IM vs only 13% in OLD (p<0.05). After 45 minutes of reoxygenation, IM and OLD had recovered 48% and 45% of their respective prehypoxic function which was two-fold greater than the 23% recovery by ADULT. Loss of cytosolic enzymes, an indicator of sarcolemmal damage, was estimated by measuring lactate dehydrogenase (LDH) release. LDH release and Ca++ content during reoxygenation in IM were only about half of that observed in ADULT or OLD. We conclude that immature and aged hearts tolerate and recover from hypoxia better than hearts from adults, and that the sarcolemmal membranes of immature rat hearts are less susceptible to damage from hypoxic stress than those of either older group.
      datePublished:2014-01-18T00:00:00Z
      dateModified:2014-01-18T00:00:00Z
      pageStart:268
      pageEnd:276
      sameAs:https://doi.org/10.1007/BF03341829
      keywords:
         Aging
         isolated heart
         oxidative stress
         reperfusion
         Geriatrics/Gerontology
      image:
      isPartOf:
         name:Aging Clinical and Experimental Research
         issn:
            1720-8319
            1594-0667
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:J. W. Starnes
            affiliation:
                  name:University of Texas at Austin
                  address:
                     name:Department of Kinesiology, University of Texas at Austin, Austin, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:D. K. Bowles
            affiliation:
                  name:University of Texas at Austin
                  address:
                     name:Department of Kinesiology, University of Texas at Austin, Austin, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:K. S. Seiler
            affiliation:
                  name:University of Texas at Austin
                  address:
                     name:Department of Kinesiology, University of Texas at Austin, Austin, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Aging Clinical and Experimental Research
      issn:
         1720-8319
         1594-0667
      volumeNumber:9
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Texas at Austin
      address:
         name:Department of Kinesiology, University of Texas at Austin, Austin, USA
         type:PostalAddress
      name:University of Texas at Austin
      address:
         name:Department of Kinesiology, University of Texas at Austin, Austin, USA
         type:PostalAddress
      name:University of Texas at Austin
      address:
         name:Department of Kinesiology, University of Texas at Austin, Austin, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:J. W. Starnes
      affiliation:
            name:University of Texas at Austin
            address:
               name:Department of Kinesiology, University of Texas at Austin, Austin, USA
               type:PostalAddress
            type:Organization
      name:D. K. Bowles
      affiliation:
            name:University of Texas at Austin
            address:
               name:Department of Kinesiology, University of Texas at Austin, Austin, USA
               type:PostalAddress
            type:Organization
      name:K. S. Seiler
      affiliation:
            name:University of Texas at Austin
            address:
               name:Department of Kinesiology, University of Texas at Austin, Austin, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Kinesiology, University of Texas at Austin, Austin, USA
      name:Department of Kinesiology, University of Texas at Austin, Austin, USA
      name:Department of Kinesiology, University of Texas at Austin, Austin, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(82)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.28s.

LINK . SPRINGER . COM {}