We are analyzing https://link.springer.com/article/10.1007/bf02252926.

Title:
Brain iron and ferritin in Parkinson's and Alzheimer's diseases | Journal of Neural Transmission: Parkinson's Disease a and Dementia Section
Description:
Semiquantitative histological evaluation of brain iron and ferritin in Parkinson
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Keywords {🔍}

article, google, scholar, pubmed, cas, iron, disease, brain, parkinsons, ferritin, alzheimers, jellinger, riederer, content, youdim, nigra, neurol, substantia, neurochem, neural, parkinsonian, brains, access, neurology, human, mbh, sci, agid, privacy, cookies, journal, grundkeiqbal, microglia, res, dexter, jenner, marsden, central, press, joshi, usa, biochem, clinical, information, publish, research, search, dementia, paulus, selective,

Topics {✒️}

month download article/chapter nincds/adrda work group soluble antigen-antibody complex horseradish peroxidase-antihorseradisch peroxidase iron-induced lipid peroxidation full article pdf melanin induced neurodegeneration mptp-mpp+-induced neurotoxicity privacy choices/manage cookies orlando san diego ludwig boltzmann institute related subjects substantia nigra resulting european economic area included frontal cortex damaged areas devoid oxidative stress van woert mh post mortem distribution long term consequences dopaminergic neurotransmission int regulatory rna sequences metal irons occurring free radical reactions calcium-binding protein 28-kilo-dalton calbindin active neuropathological process selective nigra toxicity article journal article jellinger conditions privacy policy control mrna levels magnetic resonance imaging clinico-pathological analysis total iron content article log faint iron staining iron responsive elements iron-responsive element iron storage protein glutathione peroxidase activity ben-shachar accepting optional cookies forno ls strong ferritin reactivity strong ferritin immunoreactivity journal finder publish decreased ferritin levels article cite significant selective increase

Questions {❓}

Gerber MR, Connor JR (1989) Do oligodendrocytes mediate iron regulation in human brain?
Youdim MBH, Ben-Shachar D, Riederer P (1989) Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

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         headline:Brain iron and ferritin in Parkinson's and Alzheimer's diseases
         description:Semiquantitative histological evaluation of brain iron and ferritin in Parkinson's (PD) and Alzheimer's disease (DAT) have been performed in paraffin sections of brain regions which included frontal cortex, hippocampus, basal ganglia and brain stem. The results indicate a significant selective increase of Fe3+ and ferritin in substantia nigra zona compacta but not in zona reticulata of Parkinsonian brains, confirming the biochemical estimation of iron. No such changes were observed in the same regions of DAT brains. The increase of iron is evident in astrocytes, macrophages, reactive microglia and non-pigmented neurons, and in damaged areas devoid of pigmented neurons. In substantia nigra of PD and PD/DAT, strong ferritin reactivity was also associated with proliferated microglia. A faint iron staining was seen occasionally in peripheral halo of Lewy bodies. By contrast, in DAT and PD/DAT, strong ferritin immunoreactivity was observed in and around senile plaques and neurofibrillary tangles. The interrelationship between selective increase of iron and ferritin in PD requires further investigation, because both changes could participate in the induction of oxidative stress and neuronal dath, due to their ability to promote formation of oxygen radicals.
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            Alzheimer's disease
            melanin
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      headline:Brain iron and ferritin in Parkinson's and Alzheimer's diseases
      description:Semiquantitative histological evaluation of brain iron and ferritin in Parkinson's (PD) and Alzheimer's disease (DAT) have been performed in paraffin sections of brain regions which included frontal cortex, hippocampus, basal ganglia and brain stem. The results indicate a significant selective increase of Fe3+ and ferritin in substantia nigra zona compacta but not in zona reticulata of Parkinsonian brains, confirming the biochemical estimation of iron. No such changes were observed in the same regions of DAT brains. The increase of iron is evident in astrocytes, macrophages, reactive microglia and non-pigmented neurons, and in damaged areas devoid of pigmented neurons. In substantia nigra of PD and PD/DAT, strong ferritin reactivity was also associated with proliferated microglia. A faint iron staining was seen occasionally in peripheral halo of Lewy bodies. By contrast, in DAT and PD/DAT, strong ferritin immunoreactivity was observed in and around senile plaques and neurofibrillary tangles. The interrelationship between selective increase of iron and ferritin in PD requires further investigation, because both changes could participate in the induction of oxidative stress and neuronal dath, due to their ability to promote formation of oxygen radicals.
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