We are analyzing https://link.springer.com/article/10.1007/bf02087671.

Title:
Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon-α | Digestive Diseases and Sciences
Description:
To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1β, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-α, and interleukin-6 were detected in some, but not all, HCV patients and were in general undetectable in healthy subjects. Patients had significantly higher concentrations of neopterin (P=0.0026), β2-microglobulin (P=0.046), soluble interleukin-2 receptor (P=0.021), and soluble CD8 (P<0.039), than healthy controls; conversely, interferon-γ levels were significantly lower (P=0.023). Significant correlations were observed between β2-microglobulin concentration and Knodell
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Keywords {🔍}

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Topics {✒️}

granulocyte-macrophage colony-stimulating factor granulocyte colony-stimulating factor tumor necrosis factor-α month download article/chapter vitro cell-mediated cytotoxicity activated cell-mediated immunity recombinant interferon-alpha 2a article digestive diseases soluble immune factors privacy choices/manage cookies peripheral blood monocytes soluble interleukin-2 receptor full article pdf recombinant alpha interferon recombinant alpha-interferon fundación jiménez díaz soluble interleukin-2 receptors interferon-α liver autologous liver cells interferon-gamma production chronic liver diseases altered immune reactivity adaptive immune responses significantly higher concentrations interferon-α treatment serum ifn-gamma european economic area metabolic disorders published immunoelectron microscopic observations intraportal lymphoid nodule randomized controlled trial escalating dose regime 5′-oligoadenylate synthetase activity chronic viral disease interferon-alpha treatment chronic active hepatitis liver biopsy specimens conditions privacy policy chronic viral hepatitis related subjects numerical scoring system van thiel dh julio martin bsc β2-microglobulin expression long-term clinical chronic liver disease accepting optional cookies chronic posttransfusion hepatitis interferon-γ levels sustained biochemical response

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         description:To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1β, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-α, and interleukin-6 were detected in some, but not all, HCV patients and were in general undetectable in healthy subjects. Patients had significantly higher concentrations of neopterin (P=0.0026), β2-microglobulin (P=0.046), soluble interleukin-2 receptor (P=0.021), and soluble CD8 (P<0.039), than healthy controls; conversely, interferon-γ levels were significantly lower (P=0.023). Significant correlations were observed between β2-microglobulin concentration and Knodell's index (r=0.638,P=0.00045), the score of piecemeal necrosis (r=0.572,P=0.0023), and the degree of fibrosis (r=0.527,P=0.0056). Interleukin-2 levels correlated significantly with Knodell's index (r=0.412,P=0.037), and the degree of lobular cytolysis (r=0.389,P=0.048). According to therapeutic outcome, pretreatment levels of soluble CD8 were only significantly elevated (P=0.042) in patients with a sustained biochemical response. On interferon-α treatment, the levels of β2-microglobulin, neopterin, and soluble interleukin-2 receptor increased significantly (P<0.05), irrespective of therapy outcome. In summary, HCV patients have an altered immune reactivity that might play a role in the pathogenesis of chronic hepatitis C, and might influence the therapeutic outcome to interferon-γ.
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         keywords:
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            pathogenesis
            soluble immune factors
            interferon-α therapy
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            Oncology
            Transplant Surgery
            Biochemistry
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      headline:Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon-α
      description:To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1β, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-α, and interleukin-6 were detected in some, but not all, HCV patients and were in general undetectable in healthy subjects. Patients had significantly higher concentrations of neopterin (P=0.0026), β2-microglobulin (P=0.046), soluble interleukin-2 receptor (P=0.021), and soluble CD8 (P<0.039), than healthy controls; conversely, interferon-γ levels were significantly lower (P=0.023). Significant correlations were observed between β2-microglobulin concentration and Knodell's index (r=0.638,P=0.00045), the score of piecemeal necrosis (r=0.572,P=0.0023), and the degree of fibrosis (r=0.527,P=0.0056). Interleukin-2 levels correlated significantly with Knodell's index (r=0.412,P=0.037), and the degree of lobular cytolysis (r=0.389,P=0.048). According to therapeutic outcome, pretreatment levels of soluble CD8 were only significantly elevated (P=0.042) in patients with a sustained biochemical response. On interferon-α treatment, the levels of β2-microglobulin, neopterin, and soluble interleukin-2 receptor increased significantly (P<0.05), irrespective of therapy outcome. In summary, HCV patients have an altered immune reactivity that might play a role in the pathogenesis of chronic hepatitis C, and might influence the therapeutic outcome to interferon-γ.
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      dateModified:
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      pageEnd:2496
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         pathogenesis
         soluble immune factors
         interferon-α therapy
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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