We are analyzing https://link.springer.com/article/10.1007/bf00944781.

Title:
Chronic hibernating myocardium: Interstitial changes | Molecular and Cellular Biochemistry
Description:
Chronic left ventricular dysfunctional but viable myocardium of patients with chronic hibernation is characterized by structural changes, which consist of depletion of contractile elements, accumulation of glycogen, nuclear chromatin dispersion, depletion of sarcoplasmic reticulum and mitochondrial shape changes. These alterations are not reminiscent of degeneration but are interpreted as de-differentiation of the cardiomyocytes. The above mentioned changes are accompanied by a marked increase in the interstitial space. The present study describes qualitative and quantitative changes in the cellular and non-cellular compartments of the interstitial space. In chronic hibernating myocardial segments the increased extracellular matrix is filled with large amounts of type I collagen, type III collagen and fibronectin. An increase in the number of vimentin-positive cells (endothelial cells and fibroblasts) compared with normal myocardium is seen throughout the extracellular matrix. The increase in interstitial tissue is considered as one of the main determinants responsible for the lack of immediate recovery of contractile function after restoration of the blood flow to the affected myocardial segments of patients with chronic left ventricular dysfunction.
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Keywords {🔍}

google, scholar, pubmed, collagen, myocardium, myocardial, chronic, cell, article, interstitial, ramaekers, borgers, weber, cardiac, research, ausma, thoné, flameng, heart, janicki, rat, content, hibernating, extracellular, matrix, cleutjens, left, tissue, pick, pressure, human, privacy, cookies, cells, disease, cardiovasc, res, lab, invest, cardiol, overload, hypertrophy, mol, pathol, fcs, gabbiani, muscle, actin, data, publish,

Topics {✒️}

extracellular matrix components month download article/chapter α-smooth muscle actin paraffin-embedded liver tissue carboxy-terminally deleted desmin chronic hibernating myocardium increased extracellular matrix coronary heart disease rat left ventricle related subjects extracellular matrix interstitial heart disease privacy choices/manage cookies smooth muscle differentiation regional myocardial dysfunction cellular biochemistry aims full article pdf janssen research foundation van oort flg infarcted human myocardium ventricular pressure overload affected myocardial segments van kamp gj chronically hypoperfused myocardium human primate myocardium myocardial collagen remodelling embryonic rat cardiac european economic area cardiocyte interaction published nuclear chromatin dispersion main determinants responsible vander ven pmf intermediate filament proteins struyker-boudier haj experimental wound healing diverse pathologic settings molecular cell biology experimental myocardial infarction chronic hibernation conditions privacy policy hibernating myocardium contractile protein remodelling infarcted cardiac interstitium angiographic collateral flow vimentin-positive cells vimentin free cells fibrillar collagen network de goey afpm human laminin isolated accepting optional cookies

Questions {❓}

Borgers M, Thoné F, Wouters L, Ausma J, Shivalkar B, Flameng W: Structural correlates of regional myocardial dysfunction in patients with critically coronary artery stenosis: chronic hibernation?

Schema {🗺️}

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         headline:Chronic hibernating myocardium: Interstitial changes
         description:Chronic left ventricular dysfunctional but viable myocardium of patients with chronic hibernation is characterized by structural changes, which consist of depletion of contractile elements, accumulation of glycogen, nuclear chromatin dispersion, depletion of sarcoplasmic reticulum and mitochondrial shape changes. These alterations are not reminiscent of degeneration but are interpreted as de-differentiation of the cardiomyocytes. The above mentioned changes are accompanied by a marked increase in the interstitial space. The present study describes qualitative and quantitative changes in the cellular and non-cellular compartments of the interstitial space. In chronic hibernating myocardial segments the increased extracellular matrix is filled with large amounts of type I collagen, type III collagen and fibronectin. An increase in the number of vimentin-positive cells (endothelial cells and fibroblasts) compared with normal myocardium is seen throughout the extracellular matrix. The increase in interstitial tissue is considered as one of the main determinants responsible for the lack of immediate recovery of contractile function after restoration of the blood flow to the affected myocardial segments of patients with chronic left ventricular dysfunction.
         datePublished:
         dateModified:
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         keywords:
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            basement membrane
            chronic hibernating myocardium
            collagens
            Biochemistry
            general
            Cardiology
            Cancer Research
            Medical Biochemistry
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      headline:Chronic hibernating myocardium: Interstitial changes
      description:Chronic left ventricular dysfunctional but viable myocardium of patients with chronic hibernation is characterized by structural changes, which consist of depletion of contractile elements, accumulation of glycogen, nuclear chromatin dispersion, depletion of sarcoplasmic reticulum and mitochondrial shape changes. These alterations are not reminiscent of degeneration but are interpreted as de-differentiation of the cardiomyocytes. The above mentioned changes are accompanied by a marked increase in the interstitial space. The present study describes qualitative and quantitative changes in the cellular and non-cellular compartments of the interstitial space. In chronic hibernating myocardial segments the increased extracellular matrix is filled with large amounts of type I collagen, type III collagen and fibronectin. An increase in the number of vimentin-positive cells (endothelial cells and fibroblasts) compared with normal myocardium is seen throughout the extracellular matrix. The increase in interstitial tissue is considered as one of the main determinants responsible for the lack of immediate recovery of contractile function after restoration of the blood flow to the affected myocardial segments of patients with chronic left ventricular dysfunction.
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      dateModified:
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      pageEnd:42
      sameAs:https://doi.org/10.1007/BF00944781
      keywords:
         extracellular matrix components
         basement membrane
         chronic hibernating myocardium
         collagens
         Biochemistry
         general
         Cardiology
         Cancer Research
         Medical Biochemistry
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