We are analyzing https://link.springer.com/article/10.1007/bf00686231.

Title:
Protective effects of fructose-1,6-diphosphate on acute and chronic doxorubicin cardiotoxicity in rats | Cancer Chemotherapy and Pharmacology
Description:
The effects of fructose-1,6-diphosphate, an intermediate metabolite of glycolysis, on acute and chronic cardiotoxicity of doxorubicin were investigated in rats. In the acute study, urethane-anaesthetized Wistar female rats treated with 10 mg/kg i.v. doxorubicin developed a widening of the SαT segment, an impairment of +dP/dtmax, and tachycardia. Pretreatment with 375 and 750 mg/kg i.p. fructose-1,6-diphosphate prevented the SαT segment from widening, whereas only 750 mg/kg i.p. significantly attenuated the heart rate increase. Chronic cardiomyopathy was induced over a 6-week period by wekly doses of 3 mg/kg i. v. doxorubicin, being characterized in vivo by the progressive enlargement of the SαT segment and the occurrence of histological alterations and in vitro by a marked impairment of the inotropic response elicited by adrenaline in isolated hearts from treated rats. Concurrent treatment with 150 and 300 mg/kg i. p. fructose-1,6-diphosphate thrice a week for 6 weeks did not lessen the chronic heart damage, whereas 600 mg/kg given i. p. significantly reduced the widening of the SαT segment and the severity of histological damage in vivo, as well as significantly improving the contractile responses of hearts in vitro. These findings suggest that the administration of fructose-1,6-diphosphate plays a protective role in the acute and chronic cardiotoxicity of doxorubicin in the rat.
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Topics {✒️}

heart rate increase month download article/chapter anti-oxidative stress activities adriamycin-induced histamine release anti-cancer drug adriamycin inotropic response elicited article cancer chemotherapy concurrent treatment privacy choices/manage cookies national research council full article pdf subchronic doxorubicin treatment target project “oncologia” heart cell cultures cardiac histamine release drug-induced cardiomyopathy teniposide-induced cardiotoxicity doxorubicin-induced cardiotoxicity european economic area contractile responses hippocratea africana root related subjects subacute anthracycline cardiotoxicity na+/ca2+ exchange oxygen radical formation adenine nucleotide metabolism van echteld cja phorbol-esterstimulated chemiluminescence chronic heart damage del tacca adriamycin-induced cardiotoxicity isolated rat heart conditions privacy policy check access instant access patients receiving doxorubicin 4′-o-tetrahydropyranyl-doxorubicin acute myocardial ischemia chronic cardiotoxicity produced simple experimental index bullfrog atrial muscle irreversible hemorrhagic shock isolated membrane fractions altered membrane functions chronic doxorubicin cardiotoxicity accepting optional cookies reliable electrocardiogram parameter spontaneously hypertensive rats tumor response journal finder publish

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