JNEUROINFLAMMATION . BIOMEDCENTRAL . COM {
}
Title:
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin | Journal of Neuroinflammation | Full Text
Description:
Background Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders. Objective To assess (i) the frequency of MOG-IgG in a large and predominantly Caucasian cohort of patients with optic neuritis (ON) and/or myelitis; (ii) the frequency of MOG-IgG among AQP4-IgG-positive patients and vice versa; (iii) the origin and frequency of MOG-IgG in the cerebrospinal fluid (CSF); (iv) the presence of MOG-IgG at disease onset; and (v) the influence of disease activity and treatment status on MOG-IgG titers. Methods 614 serum samples from patients with ON and/or myelitis and from controls, including 92 follow-up samples from 55 subjects, and 18 CSF samples were tested for MOG-IgG using a live cell-based assay (CBA) employing full-length human MOG-transfected HEK293A cells. Results MOG-IgG was detected in 95 sera from 50 patients with ON and/or myelitis, including 22/54 (40.7%) patients with a history of both ON and myelitis, 22/103 (21.4%) with a history of ON but no myelitis and 6/45 (13.3%) with a history of longitudinally extensive transverse myelitis but no ON, and in 1 control patient with encephalitis and a connective tissue disorder, all of whom were negative for AQP4-IgG. MOG-IgG was absent in 221 further controls, including 83 patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorders and 85 with multiple sclerosis (MS). MOG-IgG was found in 12/18 (67%) CSF samples from MOG-IgG-seropositive patients; the MOG-IgG-specific antibody index was negative in all cases, indicating a predominantly peripheral origin of CSF MOG-IgG. Serum and CSF MOG-IgG belonged to the complement-activating IgG1 subclass. MOG-IgG was present already at disease onset. The antibodies remained detectable in 40/45 (89%) follow-up samples obtained over a median period of 16.5 months (range 0–123). Serum titers were higher during attacks than during remission (p < 0.0001), highest during attacks of simultaneous myelitis and ON, lowest during acute isolated ON, and declined following treatment. Conclusions To date, this is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA. MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS. Co-existence of MOG-IgG and AQP4-IgG is highly uncommon. CSF MOG-IgG is of extrathecal origin. Serum MOG-IgG is present already at disease onset and remains detectable in the long-term course. Serum titers depend on disease activity and treatment status.
Website Age:
25 years and 10 months (reg. 1999-08-06).
Matching Content Categories {📚}
- Telecommunications
- Social Networks
- Health & Fitness
Content Management System {📝}
What CMS is jneuroinflammation.biomedcentral.com built with?
Custom-built
No common CMS systems were detected on Jneuroinflammation.biomedcentral.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of jneuroinflammation.biomedcentral.com audience?
🚄 Respectable Traffic: 10k - 20k visitors per month
Based on our best estimate, this website will receive around 10,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Jneuroinflammation.biomedcentral.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (3)
yourbow.com, google.com, doceree.comHow Much Does Jneuroinflammation.biomedcentral.com Make? {💰}
Display Ads {🎯}
$190 per month
Estimations show Jneuroinflammation.biomedcentral.com's display ad online revenue falls between $126 and $347 per month.
Keywords {🔍}
cookies, bmc, privacy, page, data, mogigg, titers, optional, content, personal, parties, policy, information, manage, journal, neuroinflammation, submission, patients, part, median, remission, acute, attacks, treated, subgroup, significant, difference, observed, untreated, article, contact, editing, authors, choice, essential, make, site, function, advertising, personalisation, usage, analysis, social, media, accepting, consent, processing, including, transfers, european,
Topics {✒️}
article page journal authors scientific editing median mog-igg titers privacy choices/manage cookies bmc european economic area state privacy rights accepting optional cookies similarly significant difference 1742-2094 contact manage preferences submission enquiries mog-igg median titers personal data optional cookies aqp4-igg significant difference data protection essential cookies cookies skip account journal cookies policy privacy policy privacy statement usage analysis social media varying standards neuroinflammation home related disorders multicenter study syndrome specificity disease activity long-term treatment status acute attacks untreated subgroup neuroinflammation issn preference centre springer nature content treated subgroup untreated patients choices privacy 50 patients treated choice make site
Schema {🗺️}
WebPage:
mainEntity:
headline:MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin
description:Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders. To assess (i) the frequency of MOG-IgG in a large and predominantly Caucasian cohort of patients with optic neuritis (ON) and/or myelitis; (ii) the frequency of MOG-IgG among AQP4-IgG-positive patients and vice versa; (iii) the origin and frequency of MOG-IgG in the cerebrospinal fluid (CSF); (iv) the presence of MOG-IgG at disease onset; and (v) the influence of disease activity and treatment status on MOG-IgG titers. 614 serum samples from patients with ON and/or myelitis and from controls, including 92 follow-up samples from 55 subjects, and 18 CSF samples were tested for MOG-IgG using a live cell-based assay (CBA) employing full-length human MOG-transfected HEK293A cells. MOG-IgG was detected in 95 sera from 50 patients with ON and/or myelitis, including 22/54 (40.7%) patients with a history of both ON and myelitis, 22/103 (21.4%) with a history of ON but no myelitis and 6/45 (13.3%) with a history of longitudinally extensive transverse myelitis but no ON, and in 1 control patient with encephalitis and a connective tissue disorder, all of whom were negative for AQP4-IgG. MOG-IgG was absent in 221 further controls, including 83 patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorders and 85 with multiple sclerosis (MS). MOG-IgG was found in 12/18 (67%) CSF samples from MOG-IgG-seropositive patients; the MOG-IgG-specific antibody index was negative in all cases, indicating a predominantly peripheral origin of CSF MOG-IgG. Serum and CSF MOG-IgG belonged to the complement-activating IgG1 subclass. MOG-IgG was present already at disease onset. The antibodies remained detectable in 40/45 (89%) follow-up samples obtained over a median period of 16.5 months (range 0–123). Serum titers were higher during attacks than during remission (p < 0.0001), highest during attacks of simultaneous myelitis and ON, lowest during acute isolated ON, and declined following treatment. To date, this is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA. MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS. Co-existence of MOG-IgG and AQP4-IgG is highly uncommon. CSF MOG-IgG is of extrathecal origin. Serum MOG-IgG is present already at disease onset and remains detectable in the long-term course. Serum titers depend on disease activity and treatment status.
datePublished:2016-10-27T00:00:00Z
dateModified:2016-10-27T00:00:00Z
pageStart:1
pageEnd:16
license:http://creativecommons.org/publicdomain/zero/1.0/
sameAs:https://doi.org/10.1186/s12974-016-0717-1
keywords:
Neuromyelitis optica (NMO)
Devic’s syndrome
Optic neuritis
Transverse Myelitis
Longitudinally extensive transverse myelitis (LETM)
Neuromyelitis optica spectrum disorders (NMOSD)
Multiple sclerosis
Autoantibodies
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG)
Neuromyelitis optica antibodies (NMO-IgG)
Aquaporin-4 antibodies (AQP4-IgG)
Cell-based assays
Cerebrospinal fluid
Antibody index
Neurosciences
Neurology
Neurobiology
Immunology
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig5_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig6_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig7_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig8_HTML.gif
isPartOf:
name:Journal of Neuroinflammation
issn:
1742-2094
volumeNumber:13
type:
Periodical
PublicationVolume
publisher:
name:BioMed Central
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Sven Jarius
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Klemens Ruprecht
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Ingo Kleiter
affiliation:
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
type:Organization
type:Person
name:Nadja Borisow
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Nasrin Asgari
affiliation:
name:University of Southern Denmark
address:
name:Department of Neurology and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
type:PostalAddress
type:Organization
type:Person
name:Kalliopi Pitarokoili
affiliation:
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
type:Organization
type:Person
name:Florence Pache
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Oliver Stich
affiliation:
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Lena-Alexandra Beume
affiliation:
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Martin W. Hümmert
affiliation:
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
type:Organization
type:Person
name:Corinna Trebst
affiliation:
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
type:Organization
type:Person
name:Marius Ringelstein
affiliation:
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
type:Organization
type:Person
name:Orhan Aktas
affiliation:
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
type:Organization
type:Person
name:Alexander Winkelmann
affiliation:
name:University of Rostock
address:
name:Department of Neurology, University of Rostock, Rostock, Germany
type:PostalAddress
type:Organization
type:Person
name:Mathias Buttmann
affiliation:
name:Julius Maximilians University
address:
name:Department of Neurology, Julius Maximilians University, Würzburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Alexander Schwarz
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Hanna Zimmermann
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Alexander U. Brandt
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Diego Franciotta
affiliation:
name:IRCCS, C. Mondino National Neurological Institute
address:
name:IRCCS, C. Mondino National Neurological Institute, Pavia, Italy
type:PostalAddress
type:Organization
type:Person
name:Marco Capobianco
affiliation:
name:Azienda Ospedaliero Universitaria San Luigi Gonzaga
address:
name:Centro di Riferimento Regionale SM, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy
type:PostalAddress
type:Organization
type:Person
name:Joseph Kuchling
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Jürgen Haas
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Mirjam Korporal-Kuhnke
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Soeren Thue Lillevang
affiliation:
name:Odense University Hospital
address:
name:Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
type:PostalAddress
type:Organization
type:Person
name:Kai Fechner
affiliation:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG
address:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG, Lübeck, Germany
type:PostalAddress
type:Organization
type:Person
name:Kathrin Schanda
affiliation:
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
type:Organization
type:Person
name:Friedemann Paul
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Brigitte Wildemann
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Markus Reindl
affiliation:
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin
description:Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders. To assess (i) the frequency of MOG-IgG in a large and predominantly Caucasian cohort of patients with optic neuritis (ON) and/or myelitis; (ii) the frequency of MOG-IgG among AQP4-IgG-positive patients and vice versa; (iii) the origin and frequency of MOG-IgG in the cerebrospinal fluid (CSF); (iv) the presence of MOG-IgG at disease onset; and (v) the influence of disease activity and treatment status on MOG-IgG titers. 614 serum samples from patients with ON and/or myelitis and from controls, including 92 follow-up samples from 55 subjects, and 18 CSF samples were tested for MOG-IgG using a live cell-based assay (CBA) employing full-length human MOG-transfected HEK293A cells. MOG-IgG was detected in 95 sera from 50 patients with ON and/or myelitis, including 22/54 (40.7%) patients with a history of both ON and myelitis, 22/103 (21.4%) with a history of ON but no myelitis and 6/45 (13.3%) with a history of longitudinally extensive transverse myelitis but no ON, and in 1 control patient with encephalitis and a connective tissue disorder, all of whom were negative for AQP4-IgG. MOG-IgG was absent in 221 further controls, including 83 patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorders and 85 with multiple sclerosis (MS). MOG-IgG was found in 12/18 (67%) CSF samples from MOG-IgG-seropositive patients; the MOG-IgG-specific antibody index was negative in all cases, indicating a predominantly peripheral origin of CSF MOG-IgG. Serum and CSF MOG-IgG belonged to the complement-activating IgG1 subclass. MOG-IgG was present already at disease onset. The antibodies remained detectable in 40/45 (89%) follow-up samples obtained over a median period of 16.5 months (range 0–123). Serum titers were higher during attacks than during remission (p < 0.0001), highest during attacks of simultaneous myelitis and ON, lowest during acute isolated ON, and declined following treatment. To date, this is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA. MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS. Co-existence of MOG-IgG and AQP4-IgG is highly uncommon. CSF MOG-IgG is of extrathecal origin. Serum MOG-IgG is present already at disease onset and remains detectable in the long-term course. Serum titers depend on disease activity and treatment status.
datePublished:2016-10-27T00:00:00Z
dateModified:2016-10-27T00:00:00Z
pageStart:1
pageEnd:16
license:http://creativecommons.org/publicdomain/zero/1.0/
sameAs:https://doi.org/10.1186/s12974-016-0717-1
keywords:
Neuromyelitis optica (NMO)
Devic’s syndrome
Optic neuritis
Transverse Myelitis
Longitudinally extensive transverse myelitis (LETM)
Neuromyelitis optica spectrum disorders (NMOSD)
Multiple sclerosis
Autoantibodies
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG)
Neuromyelitis optica antibodies (NMO-IgG)
Aquaporin-4 antibodies (AQP4-IgG)
Cell-based assays
Cerebrospinal fluid
Antibody index
Neurosciences
Neurology
Neurobiology
Immunology
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig5_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig6_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig7_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-016-0717-1/MediaObjects/12974_2016_717_Fig8_HTML.gif
isPartOf:
name:Journal of Neuroinflammation
issn:
1742-2094
volumeNumber:13
type:
Periodical
PublicationVolume
publisher:
name:BioMed Central
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Sven Jarius
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Klemens Ruprecht
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Ingo Kleiter
affiliation:
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
type:Organization
type:Person
name:Nadja Borisow
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Nasrin Asgari
affiliation:
name:University of Southern Denmark
address:
name:Department of Neurology and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
type:PostalAddress
type:Organization
type:Person
name:Kalliopi Pitarokoili
affiliation:
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
type:Organization
type:Person
name:Florence Pache
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Oliver Stich
affiliation:
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Lena-Alexandra Beume
affiliation:
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Martin W. Hümmert
affiliation:
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
type:Organization
type:Person
name:Corinna Trebst
affiliation:
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
type:Organization
type:Person
name:Marius Ringelstein
affiliation:
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
type:Organization
type:Person
name:Orhan Aktas
affiliation:
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
type:Organization
type:Person
name:Alexander Winkelmann
affiliation:
name:University of Rostock
address:
name:Department of Neurology, University of Rostock, Rostock, Germany
type:PostalAddress
type:Organization
type:Person
name:Mathias Buttmann
affiliation:
name:Julius Maximilians University
address:
name:Department of Neurology, Julius Maximilians University, Würzburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Alexander Schwarz
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Hanna Zimmermann
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Alexander U. Brandt
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Diego Franciotta
affiliation:
name:IRCCS, C. Mondino National Neurological Institute
address:
name:IRCCS, C. Mondino National Neurological Institute, Pavia, Italy
type:PostalAddress
type:Organization
type:Person
name:Marco Capobianco
affiliation:
name:Azienda Ospedaliero Universitaria San Luigi Gonzaga
address:
name:Centro di Riferimento Regionale SM, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy
type:PostalAddress
type:Organization
type:Person
name:Joseph Kuchling
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Jürgen Haas
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Mirjam Korporal-Kuhnke
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Soeren Thue Lillevang
affiliation:
name:Odense University Hospital
address:
name:Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
type:PostalAddress
type:Organization
type:Person
name:Kai Fechner
affiliation:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG
address:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG, Lübeck, Germany
type:PostalAddress
type:Organization
type:Person
name:Kathrin Schanda
affiliation:
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
type:Organization
type:Person
name:Friedemann Paul
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
type:Person
name:Brigitte Wildemann
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Markus Reindl
affiliation:
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Journal of Neuroinflammation
issn:
1742-2094
volumeNumber:13
Organization:
name:BioMed Central
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:University of Southern Denmark
address:
name:Department of Neurology and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
type:PostalAddress
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
name:University of Rostock
address:
name:Department of Neurology, University of Rostock, Rostock, Germany
type:PostalAddress
name:Julius Maximilians University
address:
name:Department of Neurology, Julius Maximilians University, Würzburg, Germany
type:PostalAddress
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:IRCCS, C. Mondino National Neurological Institute
address:
name:IRCCS, C. Mondino National Neurological Institute, Pavia, Italy
type:PostalAddress
name:Azienda Ospedaliero Universitaria San Luigi Gonzaga
address:
name:Centro di Riferimento Regionale SM, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy
type:PostalAddress
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
name:Odense University Hospital
address:
name:Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
type:PostalAddress
name:Institute of Experimental Immunology, affiliated to Euroimmun AG
address:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG, Lübeck, Germany
type:PostalAddress
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Sven Jarius
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
name:Klemens Ruprecht
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Ingo Kleiter
affiliation:
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
type:Organization
name:Nadja Borisow
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Nasrin Asgari
affiliation:
name:University of Southern Denmark
address:
name:Department of Neurology and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
type:PostalAddress
type:Organization
name:Kalliopi Pitarokoili
affiliation:
name:Ruhr University Bochum
address:
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
type:PostalAddress
type:Organization
name:Florence Pache
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Oliver Stich
affiliation:
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
type:Organization
name:Lena-Alexandra Beume
affiliation:
name:Albert Ludwigs University
address:
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
type:PostalAddress
type:Organization
name:Martin W. Hümmert
affiliation:
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
type:Organization
name:Corinna Trebst
affiliation:
name:Hannover Medical School
address:
name:Department of Neurology, Hannover Medical School, Hannover, Germany
type:PostalAddress
type:Organization
name:Marius Ringelstein
affiliation:
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
type:Organization
name:Orhan Aktas
affiliation:
name:Heinrich Heine University
address:
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
type:PostalAddress
type:Organization
name:Alexander Winkelmann
affiliation:
name:University of Rostock
address:
name:Department of Neurology, University of Rostock, Rostock, Germany
type:PostalAddress
type:Organization
name:Mathias Buttmann
affiliation:
name:Julius Maximilians University
address:
name:Department of Neurology, Julius Maximilians University, Würzburg, Germany
type:PostalAddress
type:Organization
name:Alexander Schwarz
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Hanna Zimmermann
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Alexander U. Brandt
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Diego Franciotta
affiliation:
name:IRCCS, C. Mondino National Neurological Institute
address:
name:IRCCS, C. Mondino National Neurological Institute, Pavia, Italy
type:PostalAddress
type:Organization
name:Marco Capobianco
affiliation:
name:Azienda Ospedaliero Universitaria San Luigi Gonzaga
address:
name:Centro di Riferimento Regionale SM, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy
type:PostalAddress
type:Organization
name:Joseph Kuchling
affiliation:
name:Charité-University Medicine Berlin
address:
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Jürgen Haas
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Mirjam Korporal-Kuhnke
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Soeren Thue Lillevang
affiliation:
name:Odense University Hospital
address:
name:Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
type:PostalAddress
type:Organization
name:Kai Fechner
affiliation:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG
address:
name:Institute of Experimental Immunology, affiliated to Euroimmun AG, Lübeck, Germany
type:PostalAddress
type:Organization
name:Kathrin Schanda
affiliation:
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
type:Organization
name:Friedemann Paul
affiliation:
name:Charité University Medicine
address:
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
type:PostalAddress
type:Organization
name:Charité University Medicine Berlin
address:
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
type:PostalAddress
type:Organization
name:Brigitte Wildemann
affiliation:
name:University Hospital Heidelberg
address:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Markus Reindl
affiliation:
name:Medical University Innsbruck
address:
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
type:PostalAddress
type:Organization
PostalAddress:
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
name:Department of Neurology and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
name:Department of Neurology, Ruhr University Bochum, Bochum, Germany
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
name:Department of Neurology, Albert Ludwigs University, Freiburg, Germany
name:Department of Neurology, Hannover Medical School, Hannover, Germany
name:Department of Neurology, Hannover Medical School, Hannover, Germany
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
name:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany
name:Department of Neurology, University of Rostock, Rostock, Germany
name:Department of Neurology, Julius Maximilians University, Würzburg, Germany
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
name:IRCCS, C. Mondino National Neurological Institute, Pavia, Italy
name:Centro di Riferimento Regionale SM, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy
name:Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
name:Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
name:Institute of Experimental Immunology, affiliated to Euroimmun AG, Lübeck, Germany
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
name:NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany
name:Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charité University Medicine Berlin, Berlin, Germany
name:Molecular Neuroimmunology Group, Otto Meyerhof Center, Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
name:Clinical Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
External Links {🔗}(21)
- What's the financial intake of https://www.biomedcentral.com/privacy-statement?
- How much cash flow does https://www.biomedcentral.com have monthly?
- Income figures for https://www.biomedcentral.com/journals
- What's https://www.biomedcentral.com/getpublished's gross income?
- Check the income stats for https://www.biomedcentral.com/about
- How profitable is https://www.biomedcentral.com/account?
- How much money does https://submission.nature.com/new-submission/12974/3 make?
- Revenue of https://blogs.biomedcentral.com/
- What's the financial outcome of https://www.biomedcentral.com/login?
- Learn how profitable https://authorservices.springernature.com/go/sn/?utm_source=Website&utm_medium=BMC&utm_campaign=SNAS+Referrals+2022&utm_id=ref2022 is on a monthly basis
- How much money does https://www.biomedcentral.com/about/policies generate?
- How much income is https://www.biomedcentral.com/accessibility earning monthly?
- How much money does https://www.biomedcentral.com/about/press-centre make?
- What are the earnings of https://support.biomedcentral.com/support/home?
- How much profit is https://biomedcentral.typeform.com/to/VLXboo making per month?
- How much profit is https://www.biomedcentral.com/about/jobs making per month?
- Get to know what's the income of http://www.weibo.com/biomedcentral
- What's the financial intake of https://www.biomedcentral.com/terms-and-conditions?
- How much does https://www.springernature.com/ccpa rake in every month?
- How much does https://www.biomedcentral.com/cookies pull in?
- How much does https://www.springernature.com bring in each month?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js