
DOI . ORG {
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Title[redir]:
The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis: RNA Biology: Vol 5, No 3
Description:
MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance o...
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Keywords {π}
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Topics {βοΈ}
social care medicine mirna-mediated regulatory pathway francis group twitter page taylor request academic permissions including tumor development journal search calls find guidance journals books receive personalised research journals browse citing articles based author services home play essential roles findings shed light obtain permissions instantly epithelial-mesenchymal transition pathologically relevant setting provide access read lists articles corporate permissions cart search reprints reports elucidated mirnas e-cadherin journals a open view content initiating step information crossref citations date register obtain permissions register log issues volume 5 selecting permissions permissions form search epithelial phenotype taylor publish page relevant link crossref icon find leisure tourism browse emerging role mir-200 family published online
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articleSection:Point-of-View
name:The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis
headline:The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis
abstract:MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.
description:MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.
author:
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name:Manav Korpal
type:Person
name:Yibin Kang
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