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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers

We began analyzing https://www.spandidos-publications.com/10.3892/or.2021.8093, but it redirected us to https://www.spandidos-publications.com/10.3892/or.2021.8093. The analysis below is for the second page.

Title[redir]:
circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis Retraction in /10.3892/or.2023.8672
Description:
Aberrant expression of circular RNAs (circRNAs) has been demonstrated to be related to the development of colorectal cancer (CRC), the third most common cancer worldwide. However, the mechanism of the effect of circRNA NOP2/Sun domain family, member 2 (circNSUN2) on the malignant biological behavior of CRC remains unclear. In the present study, the expression of circNSUN2 and microRNA (miR)‑181a‑5p was detected by RT‑qPCR. The expression of Rho‑associated coiled‑coil‑containing protein kinase 2 (ROCK2) was measured by western blotting. Cell proliferation was detected by CCK‑8 assay. The cell apoptosis rate was measured by flow cytometry. Cell migration ability was evaluated by Transwell assay. The interactions between circNSUN2, miR‑181a‑5p and ROCK2 were verified by dual‑luciferase reporter assay. The results revealed that circNSUN2 was highly expressed in CRC tissues and cell lines. Knockdown of circNSUN2 inhibited the malignant biological behavior of CRC <em>in vivo</em> and <em>in vitro</em>. Moreover, miR‑181a‑5p was revealed to be a target gene of circNSUN2, and the expression of ROCK2 was negatively regulated by miR‑181a‑5p. Knockdown of circNSUN2 inhibited proliferation and migration, and induced apoptosis of CRC cells and suppressed tumor growth by targeting miR‑181a‑5p to decrease ROCK2 expression. In conclusion, circNSUN2 promoted the progression of CRC by sponging miR‑181a‑5p to increase the expression of ROCK2.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌟 Strong Traffic: 100k - 200k visitors per month


Based on our best estimate, this website will receive around 100,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

cancer, mirap, circnsun, crc, cells, cell, expression, rock, article, hct, pubmedncbi, view, google, scholar, colorectal, zhang, proliferation, revealed, study, assay, apoptosis, tumor, fig, migration, biological, rtqpcr, target, present, tissues, wang, results, assessed, malignant, circrna, lines, cat, rna, behavior, liu, measured, promotes, circular, western, reporter, expressed, growth, progression, invasion, data, chen,

Topics {✒️}

mir-9/brca1/dnajb6/klf4/akt1 axis circnsun2/mir-181a-5p/rock2 axis played mir‑181a‑5p/rock2 axis retraction mi-r4435-2hg promotes proliferation circnsun2/mir-181a-5p/rock2 axis regulating wnt/β-catenin signaling 1021-335x online issn mir-181a-5p promotes proliferation mir-181a-5p overexpression resulted mir-181a-5p inhibitor transfection mir-181a-5p-mediated regulation mir-181a-5p mimics transfection circnsun2 sponged mir-181a-5p circnsun2 targeted mir-181a-5p mir-181a-5p mimics group mir-181a-5p inhibitor nc regulating mir-181a-5p expression mir-182-5p/p27 axis mir-181a-5p nc mimics mir-181a-5p inhibition restored wnt/β-catenin signaling mir-181a-5p-regulated meg2 mir-181a-5p knockdown increased circ-itga7 sponges mir-3187-3p regulating inositol polyphosphate-5-phosphatase mir-181a-5p inhibitor dual‑luciferase reporter assay dual-luciferase reporter assay mir-181a-5p mimics mir-181a-5p mimic mir-181a-5p plays sponging mir‑181a‑5p sponging mir-181a-5p small-cell lung cancer targeting mir‑181a‑5p mir-181a-5p participated targeting mir-181a-5p mir-107-mediated inhibitory effect mir-181a-5p forward mir-181a-5p decreased rock2 stabilizes β-catenin shanghai yuanye bio-technology reverse-transcription-quantitative pcr oncology molecular real-time quantitative pcr home submit manuscript mir-181a-5p based mir-181a-5p downregulated circnsun2-mediated inhibitory effect clinical oncology experimental

Social Networks {👍}(4)

External Links {🔗}(215)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics

Libraries {📚}

  • Fancybox
  • jQuery
  • jQuery module (jquery-3.4.1)
  • jQuery module (jquery-migrate-3.1.0)
  • jQuery module (jquery.fancybox)
  • jQuery module (jquery.jgrowl)
  • jQuery module (jquery.simplemodal)
  • Modernizr

Emails and Hosting {✉️}

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