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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers

We began analyzing https://www.spandidos-publications.com/10.3892/or.2014.3582, but it redirected us to https://www.spandidos-publications.com/10.3892/or.2014.3582. The analysis below is for the second page.

Title[redir]:
Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells
Description:
Smad3 and Smad4 are signaling mediators in the transforming growth factor β (TGFβ) pathway and play a major role in the progression and migration of many types of cancers. The TGFβ pathway is correlated with resistance against both targeted and conventional chemotherapeutic drugs. The aim of this study was to determine the effect of Smad3/4 on drug sensitivity in chemotherapy-resistant colorectal cancer (CRC) cells. We isolated the TGFβ-mediated chemoresistant CRC cell line DLD1-5FU-C10, which showed high expression of Smad3/4 and p21. In order to analyze the influence of Smad3/4 on drug sensitivity in DLD1-5FU-C10 cells, we knocked down Smad3/4 using small interfering RNAs (siRNA). The results showed similar drug sensitivity between the DLD1‑5FU-C10 and the DLD1 control cells and reduced p21 expression. In addition, we found a significant increase in the levels of 3 TGFβ downstream factors: interleukin 6 (IL6), plasminogen activator (PLAU) and prostaglandin-endoperoxide synthase 2 (PTGS2). Furthermore, we showed that Smad3/4 regulated the JAK1/STAT3 pathway via IL6 in the chemoresistant CRC cell line. In conclusion, we identified Smad3/4 as a novel drug sensitivity regulator in TGFβ-mediated chemotherapy-resistant CRC cells. Our results suggest that Smad3/4 regulate p-STAT3 signaling by IL6 and p21 and highlight an important role for STAT3 signaling in Smad3/4 regulated drug sensitivity in chemoresistant CRC cells.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

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🌟 Strong Traffic: 100k - 200k visitors per month


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How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

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Keywords {🔍}

smad, cells, crc, cell, dldfuc, cancer, tgfβ, sensitivity, article, view, sirna, dld, drug, google, scholar, pubmedncbi, signaling, showed, expression, human, pathway, growth, fig, chemoresistant, lines, plau, reverse, factor, ptgs, results, control, usa, colorectal, migration, study, jakstat, breast, forward, transforming, high, downstream, pstat, genes, tumor, protein, low, tgfbeta, progression, stat, treated,

Topics {✒️}

dld1-5fu-c10 cells led dld1-5fu-c10-negative sirna dld1-5fu-c10-smad4 sirna transfected dld1-5fu-c10 cells dld1-5fu-c10-smad3 sirna control dld1-5fu-c10 cells dld1-5fu-c10 cells treated isolated dld1-5fu-c10 cells 1021-335x online issn named dld1-5fu-c10 tgf-beta signal transduction dld1-5fu-c10 cells kim yj transmembrane serine-threonine kinase transcription factor p-stat3 rock/limk/cofilin pathway smad signal-transduction pathways tgf-beta receptor signaling platinum-based antineoplastic agent regulate p-stat3 signaling half-maximal inhibitory concentration interferon-gamma/stat pathway latent tgfβ-binding proteins chemotherapy-resistant colorectal cancer tgfβ growth-inhibitory effects white flat-bottomed plates dld1‑5fu-c10 dld1-5fu-c10 smad3/4 pro-migratory functions home submit manuscript numerous cancer-secreted factors secondary antibody prepared scratch/wound healing assay oncology molecular lee es tgf-beta signalling mendeley abstract smad3 epidermal growth factor human colorectal cancer human glioma cells clinical oncology experimental p21/waf1/cip1 protein tgf-beta switches tgf-beta signaling chemoresistant crc cells crc cell line chemoresistant crc progression crc cell lines cancer cell lines anticancer drug sensitivity

Social Networks {👍}(4)

External Links {🔗}(168)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics

Libraries {📚}

  • Fancybox
  • jQuery
  • jQuery module (jquery-3.4.1)
  • jQuery module (jquery-migrate-3.1.0)
  • jQuery module (jquery.fancybox)
  • jQuery module (jquery.jgrowl)
  • jQuery module (jquery.simplemodal)
  • Modernizr

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
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Name Servers:

  • josh.ns.cloudflare.com
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