
DOI . ORG {
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Title[redir]:
Capability of SART3109-118 peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles
Description:
We previously reported the SART3 gene to be a tumor-rejection antigen gene encoding a peptide at positions 109-118 (SART3109-118) with the ability to induce HLA-A24-restricted cytotoxic T lymphocytes. In this study, we investigated both humoral and cellular responses to this peptide in cancer patients with alleles other than HLA-A24 to explore the possibility of using this peptide as a cancer vaccine for these patients. IgG reactive to SART3109-118 peptide was identified in sera of the vast majority of non-cancer subjects (n=50) and all cancer patients (n=50) tested without apparent HLA-A association. Levels of anti-SART3109-118 peptide antibody in cancer patients were significantly higher than those of non-cancer subjects, but no difference was found between HLA-A24+A2− and HLA-A24−A2+ cancer patients. This peptide induced cancer cell-reactive cytotoxic T lymphocytes from peripheral blood mononuclear cells of both healthy donors and prostate cancer patients with HLA-A11, HLA-A31 and HLA-A33 alleles, but not with HLA-A2. These results suggest that this peptide can be applicable as a cancer vaccine not only for HLA-A24+, but also for HLA-A11+, HLA-A31+ and HLA-A33+ prostate cancer patients.
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Keywords {🔍}
cancer, hlaa, journal, peptide, patients, oncology, information, international, spandidos, medicine, cited, sart, total, publications, citations, articles, citation, policy, molecular, reports, academy, issue, online, editorial, contact, cytotoxic, lymphocytes, prostate, alleles, article, cookie, home, read, crossref, authors, permissions, induce, view, february, metrics, pmc, statistics, ratio, abstract, gene, vaccine, noncancer, subjects, hlaaa, related,
Topics {✒️}
induce hla-a24-restricted cytotoxic hla-a24−a2+ cancer patients 1019-6439 online issn oncology molecular hla class i-a11 anti-sart3109-118 peptide antibody home submit manuscript field citation ratio clinical oncology experimental editor general information hla-a24+a2− prostate cancer patients a33 alleles authors hla-a33 alleles total pdf downloads related articles induce cytotoxic 9 ranked oncology spandidos publications permissions contact librarians information hla-a24 hla-a24+ hla-a2 igg reactive privacy policy cancer patients cookie policy hla-a11 hla-a11+ sart3 gene cancer vaccine cancer subjects apparent hla total views total number cookie settings hla-a31 hla-a31+ sart3109-118 peptide scope abstracting advertisers reprints conditions capability february 1 3892/ijo_00000178 pages pmc statistics previously reported cellular responses vast majority significantly higher
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