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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers

We began analyzing https://www.spandidos-publications.com/10.3892/ijo.15.5.1027, but it redirected us to https://www.spandidos-publications.com/10.3892/ijo.15.5.1027. The analysis below is for the second page.

Title[redir]:
Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
Description:
Peroxisome proliferator activated receptor gamma (PPARgamma) plays a central role in the process of adipocyte differentiation. This receptor and its heterodimeric partner, retinoid X receptor alpha (RXRalpha), form a DNA-binding complex that regulates transcription of adipocyte-specific genes. Troglitazone, an antidiabetic drug, has recently been identified as a synthetic ligand for PPARgamma. We studied the effects of troglitazone on proliferation and differentiation of normal and malignant hematopoietic cells. Expression of PPARgamma was easily detectable by Western blot analyses in all five myeloid leukemia cell lines. Troglitazone alone (10-5 M) did not induce differentiation in any of the cell lines; however, this compound suppressed the clonal growth (10-75% of inhibition) of all five myeloid leukemia cell lines. Myelomonocytic U937 cells, which were the most responsive to the growth suppressing effects of troglitazone, were arrested in the G1 phase of the cell cycle when cultured with this compound. Simultaneous treatment of myeloid leukemia cell lines with both troglitazone and a ligand that specifically binds either RXR (LG100268), or retinoic acid receptors (RAR, ATRA, ALART1550), or both (9-cis RA) resulted in additive suppression of clonal growth. In summary, our studies showed that troglitazone when combined with a retinoid was a moderately potent inhibitor of clonogenic growth of acute myeloid leukemia cells.

Matching Content Categories {📚}

  • Science
  • Education
  • News & Politics

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 91,205,781 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

journal, oncology, information, troglitazone, international, spandidos, growth, myeloid, leukemia, cell, medicine, cited, cells, receptor, total, publications, citations, articles, citation, lines, policy, molecular, reports, academy, issue, online, editorial, contact, ligand, ppargamma, differentiation, article, cookie, home, read, crossref, authors, permissions, inhibition, peroxisome, proliferator, activated, gamma, view, metrics, pmc, statistics, ratio, abstract, retinoid,

Topics {✒️}

oncology molecular home submit manuscript clinical oncology experimental myeloid leukemia cells editor general information malignant hematopoietic cells myelomonocytic u937 cells 1019-6439 online issn dna-binding complex western blot analyses retinoic acid receptors moderately potent inhibitor total pdf downloads adipocyte-specific genes related articles 9 ranked oncology conditions growth inhibition growth suppressing effects cell lines spandidos publications permissions contact librarians information receptor alpha privacy policy cookie policy cell cycle total views total number cookie settings clonal growth clonogenic growth receptor adipocyte differentiation scope abstracting advertisers reprints pmc statistics central role heterodimeric partner regulates transcription antidiabetic drug easily detectable g1 phase simultaneous treatment specifically binds 9-cis ra additive suppression studies showed google scholar 9 citescore rank rights reserved

Social Networks {👍}(4)

External Links {🔗}(75)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics

Libraries {📚}

  • Fancybox
  • jQuery
  • jQuery module (jquery-3.4.1)
  • jQuery module (jquery-migrate-3.1.0)
  • jQuery module (jquery.fancybox)
  • jQuery module (jquery.jgrowl)
  • jQuery module (jquery.simplemodal)
  • Modernizr

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com
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