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We began analyzing https://www.tandfonline.com/doi/full/10.3402/ijch.v73.25760, but it redirected us to https://www.tandfonline.com/doi/full/10.3402/ijch.v73.25760. The analysis below is for the second page.

Title[redir]:
Full article: Case–control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women
Description:
Cancer is the leading cause of death among Alaska Native (AN) men and women (1). Breast cancer is among the most frequently diagnosed cancers in this population; from 2004 to 2008, breast cancer ac...

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Education
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Science

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Based on our best estimate, this website will receive around 96,105,781 visitors per month in the current month.

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Keywords {🔍}

cancer, open, breast, women, citation, health, exposure, study, concentrations, environmental, windowgoogle, scholar, science, source, alaska, risk, windowweb, native, association, serum, windowpubmed, journal, phthalate, chemicals, studies, metabolites, bde, reported, pesticides, lipid, phthalates, polybrominated, ngg, higher, pbde, pcbs, persistent, measured, results, organochlorine, human, sciences, case, status, control, factors, population, controls, urine, samples,

Topics {✒️}

ahr/hdac6/c-myc signaling pathway semiautomated high–throughput extraction social care medicine estrogen receptor-dependent mechanism rubinvector-borneand enteric diseases google scholar buteau–lozano google scholar st-hilaire breast-related health issues benign breast conditions google scholar lópez-cervantes vitro anti-androgenic effects vitro anti–androgenic effects nested case–control study risk factor information body mass index twitter page taylor google scholar lópez-carrillo chronic low-dose exposure larger population-based studies oestrogen-negative/progesterone-negative high body burdens environmental medicine associations references day environment international phthalates oestrogen-positive/progesterone-positive select environmental chemicals quantify chemical exposures laboratory sciences polychlorinated biphenyl residues improved quantitative detection alaska area er–/pr– tumours type francis group recent case–control study er–/pr– tumour types phthalates induce proliferation holmeshealth studies branchdivision kieszakhealth studies branchdivision polybrominated flame retardant er/pr-negative tumours alaska native adults hormone receptor status estrogen receptor status organochlorine exposures influence including er/pr status polybrominated diphenyl ethers short half-life breast cancer research personal identifying information breast cancer development

Questions {❓}

Are brominated flame retardants endocrine disruptors?
Are brominated flame retardants endocrine disruptors?
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Schema {🗺️}

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      articleSection:Original Research Articles
      name:Case–control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women
      headline:Case–control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women
      abstract:Background Exposure to environmental chemicals may impair endocrine system function. Alaska Native (AN) women may be at higher risk of exposure to these endocrine disrupting chemicals, which may contribute to breast cancer in this population. Objective To measure the association between exposure to select environmental chemicals and breast cancer among AN women. Design A case–control study of 170 women (75 cases, 95 controls) recruited from the AN Medical Center from 1999 to 2002. Participants provided urine and serum samples. Serum was analyzed for 9 persistent pesticides, 34 polychlorinated biphenyl (PCB) congeners, and 8 polybrominated diethyl ether (PBDE) congeners. Urine was analyzed for 10 phthalate metabolites. We calculated geometric means (GM) and compared cases and controls using logistic regression. Results Serum concentrations of most pesticides and 3 indicator PCB congeners (PCB-138/158; PCB-153, PCB-180) were lower in case women than controls. BDE-47 was significantly higher in case women (GM=38.8 ng/g lipid) than controls (GM=25.1 ng/g lipid) (p=0.04). Persistent pesticides, PCBs, and most phthalate metabolites were not associated with case status in univariate logistic regression. The odds of being a case were higher for those with urinary mono-(2-ethylhexyl) phthalate (MEHP) concentrations that were above the median; this relationship was seen in both univariate (OR 2.16, 95% CI 1.16–4.05, p=0.02) and multivariable (OR 2.43, 95% CI 1.13–5.25, p=0.02) logistic regression. Women with oestrogen receptor (ER)–/progesterone receptor (PR)-tumour types tended to have higher concentrations of persistent pesticides than did ER+/PR+ women, although these differences were not statistically significant. Conclusions Exposure to the parent compound of the phthalate metabolite MEHP may be associated with breast cancer. However, our study is limited by small sample size and an inability to control for the confounding effects of body mass index. The association between BDE-47 and breast cancer warrants further investigation.
      description:Background Exposure to environmental chemicals may impair endocrine system function. Alaska Native (AN) women may be at higher risk of exposure to these endocrine disrupting chemicals, which may contribute to breast cancer in this population. Objective To measure the association between exposure to select environmental chemicals and breast cancer among AN women. Design A case–control study of 170 women (75 cases, 95 controls) recruited from the AN Medical Center from 1999 to 2002. Participants provided urine and serum samples. Serum was analyzed for 9 persistent pesticides, 34 polychlorinated biphenyl (PCB) congeners, and 8 polybrominated diethyl ether (PBDE) congeners. Urine was analyzed for 10 phthalate metabolites. We calculated geometric means (GM) and compared cases and controls using logistic regression. Results Serum concentrations of most pesticides and 3 indicator PCB congeners (PCB-138/158; PCB-153, PCB-180) were lower in case women than controls. BDE-47 was significantly higher in case women (GM=38.8 ng/g lipid) than controls (GM=25.1 ng/g lipid) (p=0.04). Persistent pesticides, PCBs, and most phthalate metabolites were not associated with case status in univariate logistic regression. The odds of being a case were higher for those with urinary mono-(2-ethylhexyl) phthalate (MEHP) concentrations that were above the median; this relationship was seen in both univariate (OR 2.16, 95% CI 1.16–4.05, p=0.02) and multivariable (OR 2.43, 95% CI 1.13–5.25, p=0.02) logistic regression. Women with oestrogen receptor (ER)–/progesterone receptor (PR)-tumour types tended to have higher concentrations of persistent pesticides than did ER+/PR+ women, although these differences were not statistically significant. Conclusions Exposure to the parent compound of the phthalate metabolite MEHP may be associated with breast cancer. However, our study is limited by small sample size and an inability to control for the confounding effects of body mass index. The association between BDE-47 and breast cancer warrants further investigation.
      author:
            type:Person
            name:Adrianne K. Holmes
            type:Person
            name:Kathryn R. Koller
            type:Person
            name:Stephanie M. Kieszak
            type:Person
            name:Andreas Sjodin
            type:Person
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            type:Person
            name:Frank D. Sacco
            type:Person
            name:D. Wayne Varner
            type:Person
            name:Anne P. Lanier
            type:Person
            name:Carol H. Rubin
      keywords:phthalates, polychlorinated biphenyl ethers, persistent pesticides, environmental chemical exposure, breast cancer, Alaska Native
      datePublished:2014-11-13
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      name:Andreas Sjodin
      name:Antonia M. Calafat
      name:Frank D. Sacco
      name:D. Wayne Varner
      name:Anne P. Lanier
      name:Carol H. Rubin
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