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Title[redir]:
Frontiers | Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy
Description:
Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy and fibrosis. Studies in 2 mouse models (R92W-TnT/R403Q-MyHC) at early ...
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Keywords {🔍}
cardiac, expression, hcm, myocytes, tgfβ, genes, gene, mouse, fibroblasts, google, scholar, doi, text, abstract, crossref, full, pubmed, data, control, human, mira, figure, compared, patients, heart, tnt, tgfb, profibrotic, weeks, tissue, age, rat, fibrosis, controls, littermate, myectomy, collagen, signaling, myhc, hypertrophic, cardiomyopathy, studies, mutant, redox, differences, myocyte, mutants, treatment, mirabc, mice,
Topics {✒️}
compensatory anti-hypertrophic/anti-fibrotic pathways tumour-suppressive mir-29a/b1 cluster ccaat/enhancer-binding protein-α pro-fibrotic/pro-hypertrophic tgfβ/et1 signaling renin receptor mannose-6-phosphate/insulin influences myosin-atpase activity anti-hypertrophic/anti-fibrotic genes data availability statement anti-hypertrophic/anti-fibrotic liver et1 + n-acetyl-l-cysteine pcr-amplified tail dna et1-mediated collagen deposition/fibrosis reactive oxygen species real-time rt-pcr human beta-cardiac myosin antifibrotic genes/pathways selectively renin-angiotensin-aldosterone system myosin heavy chain enhanced chemi-luminescence reagent current hgnc/ncbi nomenclature alpha-smooth muscle actin age/sex-matched donor hearts tgfβ2 suppress mir-29a tgfβ1/tgfβ2 suppressed mir-29a mir-29a-mimic prevented upregulation tgf-beta isoform upregulated pro-fibrotic target genes open-access article distributed pkc-dependent atf-2 activation antihypertrophic/antifibrotic genes/pathways et1-induced cardiac hypertrophy pro-fibrotic genes/pathways pro-fibrotic gene expression tgfβ-induced collagen expression renin-binding protein cellular stress response/fibrosis neonatal rat pups reduced cellular superoxide/h2o2 suppressed mir-29a expression hcm-var-risk model requiring heart transplantation supplementary material pro-hypertrophic et1 signaling neonatal rat hearts stimulated tgfβ expression/secretion hcm patient genotype/phenotype tgfβ-stimulated collagen expression mir-29a overexpression studies log2 fold-change compared research search frontiers
Schema {🗺️}
ScholarlyArticle:
context:https://schema.org
headline:Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy
author:
type:Person
name:Yamin Liu
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
type:Person
name:Junaid Afzal
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
type:Person
name:Styliani Vakrou
affiliation:
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
type:Person
name:Gabriela V. Greenland
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
type:Person
name:C. Conover Talbot
affiliation:
Johns Hopkins School of Medicine, Institute for Basic Biomedical Sciences, United States
type:Person
name:Virginia B. Hebl
affiliation:
Intermountain Medical Center, Intermountain Heart Institute, United States
type:Person
name:Yufan Guan
affiliation:
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
type:Person
name:Rehan Karmali
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
type:Person
name:Jil C. Tardiff
affiliation:
Sarver Heart Center, University of Arizona Health Sciences, United States
type:Person
name:Leslie A. Leinwand
affiliation:
Molecular, Cellular and Developmental Biology, Biofrontiers Institute, University of Colorado, United States
type:Person
name:Jeffrey E. Olgin
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
type:Person
name:Samarjit Das
affiliation:
Department of Anesthesia and Critical Care Medicine, Johns Hopkins University, United States
type:Person
name:Ryuya Fukunaga
affiliation:
Department of Biological Chemistry, Johns Hopkins School of Medicine, United States
type:Person
name:M. Roselle Abraham
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
datePublished:2019-12-17
dateModified:2025-07-01
publisher:
type:Organization
name:Frontiers
isPartOf:
type:PublicationIssue
datePublished:2019
isPartOf:
type:PublicationVolume
volumeNumber:6
isPartOf:
type:Periodical
name:Frontiers in Cardiovascular Medicine
citation:
https://doi.org/10.3389/fcvm.2019.00170
inLanguage:en
Person:
name:Yamin Liu
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
name:Junaid Afzal
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
name:Styliani Vakrou
affiliation:
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
name:Gabriela V. Greenland
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
name:C. Conover Talbot
affiliation:
Johns Hopkins School of Medicine, Institute for Basic Biomedical Sciences, United States
name:Virginia B. Hebl
affiliation:
Intermountain Medical Center, Intermountain Heart Institute, United States
name:Yufan Guan
affiliation:
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
name:Rehan Karmali
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
name:Jil C. Tardiff
affiliation:
Sarver Heart Center, University of Arizona Health Sciences, United States
name:Leslie A. Leinwand
affiliation:
Molecular, Cellular and Developmental Biology, Biofrontiers Institute, University of Colorado, United States
name:Jeffrey E. Olgin
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
name:Samarjit Das
affiliation:
Department of Anesthesia and Critical Care Medicine, Johns Hopkins University, United States
name:Ryuya Fukunaga
affiliation:
Department of Biological Chemistry, Johns Hopkins School of Medicine, United States
name:M. Roselle Abraham
affiliation:
Division of Cardiology, Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, United States
Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, United States
Organization:
name:Frontiers
PublicationIssue:
datePublished:2019
isPartOf:
type:PublicationVolume
volumeNumber:6
isPartOf:
type:Periodical
name:Frontiers in Cardiovascular Medicine
PublicationVolume:
volumeNumber:6
isPartOf:
type:Periodical
name:Frontiers in Cardiovascular Medicine
Periodical:
name:Frontiers in Cardiovascular Medicine
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