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Title[redir]:
Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity
Description:
While most of the investigations into the causative events in the development of alcoholic liver disease (ALD) have been focused on multiple factors, increasing interest has centered around the possible role of immune mechanisms in the pathogenesis and perpetuation of ALD. This is because many of the clinical features of ALD suggest that immune effector mechanisms may be contributing to liver tissue damage, as evidenced by the detection of circulating autoantibodies, and the presence of CD4+ and CD8+ lymphoid cells in the livers of patients with ALD. One mechanism that has been associated with the development of autoimmune responses is the modification (haptenation or adduction) of liver proteins with aldehydes or other products of oxidative stress. This is because it has been shown that these adducted proteins can induce specific immune responses, to the adduct, the adduct plus protein (conformational antigens), as well as the unmodified parts of the protein. More importantly, it is possible to demonstrate that adducted self-proteins can induce reactivity to the normal self-protein and thereby induce autoimmune responses. Therefore, it is the purpose of this manuscript to outline the mechanism(s) by which these modified self proteins can induce autoimmune reactivity, and thus play a role in the development and/or progression of ALD.
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Keywords {π}
article, issue, imr, center, press, medical, ald, volume, fbl, mechanisms, liver, nebraska, omaha, induce, published, department, development, immune, autoimmune, responses, proteins, events, submit, articles, special, authors, countries, regions, types, year, search, cite, pdf, link, geoffrey, thiele, frontiers, previous, alcohol, damage, aldehydes, university, veterans, administration, pathology, front, biosci, landmark, role, adducted,
Topics {βοΈ}
special issue cite imr press contact regions countries issue share back alcohol liver damage nebraska medical center imrΒ press article mechanisms article nanoparticles previous article link geoffrey cd8+ lymphoid cells alcoholic liver disease liver tissue damage induce autoimmune responses articles special issues //doi immune effector mechanisms induce autoimmune reactivity article fbl review fbl apply issue ne 68198-6495 front autoimmune responses induce reactivity immune mechanisms fbl causative events previous articles liver proteins journals resources subscription basis scavenger receptors autoimmunity michael affiliation 1 university internal medicine 4101 woolworth avenue landmark ed multiple factors increasing interest clinical features circulating autoantibodies oxidative stress conformational antigens unmodified parts top front privacy policy bioscience-landmark terms & conditions
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