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We began analyzing https://www.tandfonline.com/doi/full/10.2217/imt.11.163, but it redirected us to https://www.tandfonline.com/doi/full/10.2217/imt.11.163. The analysis below is for the second page.

Title[redir]:
Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus: Immunotherapy: Vol 4 , No 2 - Get Access
Description:
Discriminating antigen-recognition and -response mechanisms must be employed by the intestinal immune system in order to protect against potential pathogens, regulate inflammation and induce oral t...

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article, information, taylor, francis, access, log, online, author, financial, usaview, group, page, search, cells, journals, register, cart, issue, immune, research, department, nck, production, authors, manuscript, pdf, content, add, read, work, medicine, intestinal, lipoteichoic, lactobacillus, acidophilus, university, infectious, diseases, pathology, emerging, pathogens, institute, box, ave, gainesville, materials, strain, dendritic, open, login,

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lipoteichoic acid-deficient strain pathogenic cd4+cd25-cd45rbhi colonic inflammatory conditions activated foxp3+ tregs dendritic cells downloaded article pdf francis group downloaded article pdfs limited period receive personalised research khan1 northwestern university animal experimental investigations immune response journals books mojgan zadeh2 department emerging pathogens institute praveen bere2 department jennifer owen2 department todd klaenhammer3 department affect host immunity effective immunotherapeutic approach nih grant 1r01ai098833-01 access rights institution access date register additional information funding lipoteichoic acid nc state university author information show macrophages article https cells published online cart search financial involvement financial interest financial conflict register log parental strain read issues volume 4 cell wall author information taylor feinberg school po box 110880 materials & methods intraperitoneal injection rag1-/- mice administered orally

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      articleSection:Research Article
      name:Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus
      headline:Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus
      abstract:Aim: To investigate the mechanism(s) by which the intestinal commensal microbe Lactobacillus acidophilus can affect host immunity, we studied the role of a component of the cell wall, lipoteichoic acid, in colitis. Materials &amp; methods: Colitis was induced by the intraperitoneal injection of pathogenic CD4+CD25-CD45RBhi T cells into Rag1-/- mice. The parental strain, NCK56, or the lipoteichoic acid-deficient strain, NCK2025, was then administered orally. Fluorescent microscopy was employed to examine resulting cell populations and their cytokine production in the colon. Results: NCK2025 enhanced IL-10 production by dendritic cells and macrophages. Increased numbers of regulatory dendritic cells coincided with the induction of activated FoxP3+ Tregs. Conclusion: These results suggest that the oral administration of the genetically modified strain NCK2025 may be an effective immunotherapeutic approach that reprograms the immune response in colonic inflammatory conditions.
      description:Aim: To investigate the mechanism(s) by which the intestinal commensal microbe Lactobacillus acidophilus can affect host immunity, we studied the role of a component of the cell wall, lipoteichoic acid, in colitis. Materials &amp; methods: Colitis was induced by the intraperitoneal injection of pathogenic CD4+CD25-CD45RBhi T cells into Rag1-/- mice. The parental strain, NCK56, or the lipoteichoic acid-deficient strain, NCK2025, was then administered orally. Fluorescent microscopy was employed to examine resulting cell populations and their cytokine production in the colon. Results: NCK2025 enhanced IL-10 production by dendritic cells and macrophages. Increased numbers of regulatory dendritic cells coincided with the induction of activated FoxP3+ Tregs. Conclusion: These results suggest that the oral administration of the genetically modified strain NCK2025 may be an effective immunotherapeutic approach that reprograms the immune response in colonic inflammatory conditions.
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            name:Mansour Mohamadzadeh
            type:Person
            name:Todd Klaenhammer
            type:Person
            name:Jennifer Owen
            type:Person
            name:Elias Gounaris
            type:Person
            name:Praveen Bere
            type:Person
            name:Mojgan Zadeh
            type:Person
            name:Mohammad W Khan
      keywords:dendritic cells, Lactobacillus acidophilus, macrophages, regulatory innate immune cells, Tregs
      pageStart:151
      pageEnd:161
      datePublished:2012-02-17
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      name:Todd Klaenhammer
      name:Jennifer Owen
      name:Elias Gounaris
      name:Praveen Bere
      name:Mojgan Zadeh
      name:Mohammad W Khan
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