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Keywords {🔍}

cancer, pembrolizumab, patients, hnscc, head, neck, pdl, response, cell, risk, hpv, immune, oncol, treatment, chemotherapy, keynote, squamous, carcinoma, tobacco, hnc, reported, disease, tumor, hpvpositive, clin, recurrent, oral, alcohol, inhibitors, smoking, hncs, metastatic, median, checkpoint, tumors, phase, trial, life, expression, orr, advanced, consumption, human, infection, therapy, quality, incidence, study, press, clinical,

Topics {✒️}

gov/news-events/cancer-currents-blog/2016/fda-pembrolizumab-hnscc org/press-office/press-releases/keynote-040-evaluates-pembrolizumab org/meeting-resources/esmo-2016/updated-safety gov/drugs/informationondrugs/approveddrugs/ucm528920 anti-programmed-death-receptor-1 treatment treatment-related adverse events downregulate t-cell activation express cytotoxic t-lymphocyte a-squamous-cell-carcinoma anti-pd1 checkpoint inhibitor including fast-track processing transforming growth factor-beta ipilimumab-refractory advanced melanoma anti-programmed death-1 agent dove medical press anti-pd-l-1-antibody epstein-barr virus-tumors virus-related cancer epidemic ifn-γ signature score gene ifn-γ signature anti-pd-l1 agent interferon-γ signature score neck cancer-systematic review manuscript login reach steady-state concentration recurrent squamous-cell carcinoma mismatch repair deficiency open-label study middle-aged white men positive pd-l1 status pd-l1 expression subgroups receiving platinum-based chemotherapy locally advanced disease favored authors neck-scchn-expansion-cohort pd-1/pd-l1 inhibitors evidence-based treatment options pd-1/pd-l1 pathway pd-l1 expression analysis hpv-negative hnc decreased squamous cell carcinoma pd-l1-positive hncs hpv-positive hnc tumors specific author pd-1/pd-l1 interaction randomised dose-comparison cohort cd8+ t-cells overexpressed/mutated antigens pd-1/pd-l2 interactions pd-l1-positive patients

Questions {❓}

• Progress in head and neck cancer immunotherapy: can tolerance and immune suppression be reversed?
• Why publish with us?

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