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Title[redir]:
Low expression of mixed lineage kinase domain-like protein is associat | OTT
Description:
Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients Ling He,1 Kuan Peng,2 Yizhi Liu,1 Jing Xiong,1 Fu-fan Zhu1 1Department of Gynecology and Obstetrics, The Second Xiangya Hospital of Central South University, 2Institute of Biomedical Engineering, School of Info-Physics and Geomatics Engineering, Central South University, Changsha, People’s Republic of China Background: Mixed lineage kinase domain-like protein (MLKL) was initially identified as a key receptor interacting protein 3 downstream component of tumor-necrosis-factor-induced necrosis. In this study, we characterized the expression of MLKL in ovarian carcinomas and evaluated the prognostic value of MLKL in patients with ovarian cancer. Materials and methods: The ovarian cancer tissue specimens were collected from 153 patients diagnosed as primary ovarian cancer after operation at The Second Xiangya Hospital from January 2005 to December 2008. Immunohistochemistry was performed for MLKL and the protein expression score was quantified using an established scoring system. Kaplan–Meier survival curves were generated for disease-free survival (DFS) and overall survival (OS) for all patients. MLKL expression levels were correlated with DFS and OS using univariate and multivariate Cox regression analysis. Results: Seventy-five patients (49%) were defined as having high MLKL expression and 67 patients (43.7%) had >80% of cells staining for MLKL. Remarkably, low MLKL expression was significantly associated with decreased DFS (median 40 months versus 25 months, P=0.0282) and OS (median 43 months versus 28 months, P=0.0032). In multivariate analysis, retained significance was also observed. Conclusion: Low MLKL expression was significantly associated with both decreased DFS and OS in patients with primary ovarian cancer. MLKL expression may serve as a potential prognostic marker in patients with ovarian cancer. Keywords: MLKL, ovarian cancer, prognostic value
Title[redir]:
Low expression of mixed lineage kinase domain-like protein is associat | OTT
Description:
Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients Ling He,1 Kuan Peng,2 Yizhi Liu,1 Jing Xiong,1 Fu-fan Zhu1 1Department of Gynecology and Obstetrics, The Second Xiangya Hospital of Central South University, 2Institute of Biomedical Engineering, School of Info-Physics and Geomatics Engineering, Central South University, Changsha, People’s Republic of China Background: Mixed lineage kinase domain-like protein (MLKL) was initially identified as a key receptor interacting protein 3 downstream component of tumor-necrosis-factor-induced necrosis. In this study, we characterized the expression of MLKL in ovarian carcinomas and evaluated the prognostic value of MLKL in patients with ovarian cancer. Materials and methods: The ovarian cancer tissue specimens were collected from 153 patients diagnosed as primary ovarian cancer after operation at The Second Xiangya Hospital from January 2005 to December 2008. Immunohistochemistry was performed for MLKL and the protein expression score was quantified using an established scoring system. Kaplan–Meier survival curves were generated for disease-free survival (DFS) and overall survival (OS) for all patients. MLKL expression levels were correlated with DFS and OS using univariate and multivariate Cox regression analysis. Results: Seventy-five patients (49%) were defined as having high MLKL expression and 67 patients (43.7%) had >80% of cells staining for MLKL. Remarkably, low MLKL expression was significantly associated with decreased DFS (median 40 months versus 25 months, P=0.0282) and OS (median 43 months versus 28 months, P=0.0032). In multivariate analysis, retained significance was also observed. Conclusion: Low MLKL expression was significantly associated with both decreased DFS and OS in patients with primary ovarian cancer. MLKL expression may serve as a potential prognostic marker in patients with ovarian cancer. Keywords: MLKL, ovarian cancer, prognostic value
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Keywords {🔍}
mlkl, press, medical, expression, ovarian, patients, dove, cancer, authors, work, open, published, learn, protein, dfs, months, terms, informa, reprints, access, journals, peer, review, low, permission, article, prognostic, survival, plc, contact, testimonials, favored, author, login, scientific, papers, manuscript, volume, mixed, lineage, kinase, domainlike, peng, liu, xiong, zhu, download, pdf, xiangya, hospital,
Topics {✒️}
tumor-necrosis-factor-induced necrosis including fast-track processing dove medical press kaplan–meier survival curves manuscript login favored authors specific author offer real benefits review central south university established scoring system author academic publishing division london sw1p 1wg uk vat group primary ovarian cancer low mlkl expression protein expression score disease-free survival papers mlkl expression levels high mlkl expression articles published potential prognostic marker article authors informa plc medical journals multivariate analysis ovarian cancer published ovarian carcinomas mlkl expression full terms journals » oncotargets scientific journal alerts pharmaceutical industry poor prognosis s52805 checked xiangya hospital biomedical engineering info-physics geomatics engineering china background initially identified cells staining retained significance properly attributed opinions expressed necessarily reflect
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