DOI . ORG {}

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We began analyzing https://www.oncotarget.com/article/8087/text/, but it redirected us to https://www.oncotarget.com/article/8087/text/. The analysis below is for the second page.

Title[redir]:
RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence | Oncotarget
Description:
// Xiaoyu Cai 1,* , Yuanyuan Hu 1,* , Hao Tang 2 , Han Hu 1 , Lijun Pang 1 , Junyue Xing 1 , Zhenyun Liu 1 , Yuhong Luo 2 , Bin Jiang 1 , Te Liu 4 , Myriam Gorospe 3 , Chuan Chen 4 and Wengong Wang 1 1 Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, P. R. China 2 Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, P.R. China 3 Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA 4 Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China * These authors have contributted equally to this work Correspondence to: Chuan Chen, email: // Wengong Wang, email: // Keywords : NSUN2, SHC mRNA methylation, translational regulation, HUVEC, premature senescence, Gerotarget Received : January 25, 2016 Accepted : February 23, 2016 Published : March 15, 2016 Abstract The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC. Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC). Our findings highlight the critical impact of NSUN2-mediated mRNA methylation in promoting premature senescence.

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Keywords {🔍}

shc, utr, nsun, pshc, mrna, senescence, methylation, levels, cells, figure, translation, analysis, cell, expression, positions, oxidative, huvecs, vitro, stress, fragments, rna, shown, methylated, premature, cellular, replicative, ros, subjected, data, analyzed, proteins, nsunmediated, human, knockdown, independent, experiments, sites, protein, assays, utrm, lucutrm, high, test, activity, lucutr, oncotarget, aging, regulation, cdk, reporter,

Topics {✒️}

high-glucose-induced endothelial dysfunction high-glucose-induced premature senescence prevalent post-transcriptional modification sa-β-galactosidase staining hyperglycemia-induced endothelial dysfunction myc-induced sun domain mediates myc-induced proliferation sa-β-gal analysis short-wavelength ultraviolet irradiation nonisotopic s-adenosyl methionine micro bio-spin6 columns sa-β-gal activity nop2/sun domain family ros-induced vascular dysfunction high-glucose-induced senescence fluorescence-activated cell sorting pgl3-derived reporter vectors inaugural editorial cell-free translation system housekeeping protein β-actin prl-cmv control reporter oxidative stress-induced apoptosis publication alerts subscribe oxidative stress-induced senescence open-access journal dedicated thermo fisher scientific nsun2-shc regulatory axis real-time qpcr analysis nsun2-mediated cytosine-5 methylation free publication nsun2-mediated mrna methylation mitochondrial redox signaling site-specific epigenetic regulation ras signaling pathway rna methyltransferase misu premature senescence induced luc-3’utrm reporter transcripts polyclonal anti-cyclin b1 senescence program triggered rnase-free water ribosomal decoding center β-gal] activity western blot analysis polyclonal anti-p-p38 rt-qpcr data represent nsun2-modulated p27 stress-induced cleavage high glucose decreases human diploid fibroblasts high glucose increased

Questions {❓}

P66SHC and ageing: ROS and TOR?

Schema {🗺️}

Article:
      license:https://creativecommons.org/licenses/by/4.0/
      publisher:
         type:Organization
         name:Oncotarget
         logo:
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            url:https://www.oncotarget.com/images/oncotarget-logo-square.png
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      dateModified:2016-06-09T22:02:06Z
      mainEntityOfPage:
         type:WebPage
         id:https://www.oncotarget.com/article/8087/text/
      headline:RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
      articleSection:Research Papers: Gerotarget (Focus on Aging)
      sameAs:https://doi.org/10.18632/oncotarget.8087
      image:https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=viewFile&path%5B%5D=8087&path%5B%5D=23836&path%5B%5D=123095
      datePublished:2016-03-15T00:00:00Z
      author:
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            name:Cai, Xiaoyu
            type:Person
            name:Hu, Yuanyuan
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         url:https://www.oncotarget.com/images/oncotarget-logo-square.png
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Person:
      name:Cai, Xiaoyu
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      name:Liu, Te
      name:Gorospe, Myriam
      name:Chen, Chuan
      name:Wang, Wengong

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