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We began analyzing https://www.oncotarget.com/article/18545/text/, but it redirected us to https://www.oncotarget.com/article/18545/text/. The analysis below is for the second page.

Title[redir]:
The positivity of G-protein-coupled receptor-30 (GPR 30), an alternative estrogen receptor is not different between type 1 and type 2 endometrial cancer | Oncotarget
Description:
// Jiayi Wan 1, * , Yongxiang Yin 2, * , Min Zhao 2 , Fang Shen 3 , Miaoxin Chen 4 and Qi Chen 3, 5 1 Department of Pathology, Wuxi No2 People’s Hospital, Nanjing Medical University, Wuxi, China 2 Department of Pathology, Wuxi Maternity and Children Hospital, Nanjing Medical University, Wuxi, China 3 The Hospital of Obstetrics and Gynaecology, Fudan University, Shanghai, China 4 Centre for Reproductive Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China 5 Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand * These authors contributed equally to this work Correspondence to: Qi Chen, email: [email protected] Keywords: endometrial cancer, GPR30, estrogen receptor, menopause, type 1 and type 2 Received: February 13, 2017      Accepted: June 04, 2017      Published: June 17, 2017 ABSTRACT It is well-known that the clinical outcomes are different between type 1 (estrogen dependent) and type 2 (estrogen independent) endometrial cancer. Studies have suggested that the estrogen receptor (ER) is positively correlated with endometrial cancer survival, however we previously reported that there is no difference in the positivity of ER as well as sex hormone levels between subtypes of cancer. G-protein-coupled receptor-30 (GPR 30), an alternative estrogen receptor has been suggested to be negatively correlated with clinical outcomes of endometrial cancer. In this study we investigated whether the positivity of GPR30 is different between subtypes of cancer. The immunostaining of GPR30 and ER was examined and analysed in 128 cases taking into account menopausal status. Overall, 105 (82%) cases were GPR30 positive and 118 (92%) cases were ER positive. The positivity of GPR30 in type 1 endometrial cancer (83%) was not statistically different to type 2 endometrial cancer (78%). In addition, intensity of immunostaining of GPR30 in type 1 endometrial cancer was also not different to type 2 endometrial cancer quantified by semi-quantitative analysis ( p = 0.268). Menopausal status was not associated with the positivity of GPR30 in both type 1 and type 2 endometrial cancer. Furthermore, the positivity and intensity of immunostaining of GPR30 were not correlated with the positivity and intensity of immunostaining of ER in endometrial cancer ( p = 0.689). Our data further confirm that type 2 endometrial cancer may not be completely estrogen independent, and suggest that type 1 and type 2 endometrial cancer may have similar pathogenesis.

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Keywords {🔍}

cancer, endometrial, type, gpr, positivity, estrogen, positive, study, receptor, cases, women, immunostaining, intensity, difference, table, number, menopausal, status, oncotarget, subtypes, postmenopausal, clinical, menopause, cells, premenopausal, survival, risk, staining, expression, reported, hospital, correlated, analysis, data, patients, chen, university, found, factors, statistical, negative, outcomes, independent, suggested, age, breast, chinese, carcinoma, gynecol, current,

Topics {✒️}

biotinylated anti-mouse/rabbit igg orphan g-protein-coupled receptor irrelevant mouse/rabbit serum streptavidin-conjugated horseradish peroxidase g-protein-coupled receptor-30 inaugural editorial free publication membrane-spanning estrogen receptor mouse anti-human er publication alerts subscribe open-access journal dedicated protein-coupled receptor gpr30 protein-coupled receptor ethics committee pi3k/akt pathway transmembrane estrogen receptor rapid nongenomic effect high-grade histotypes maximize research impact van de vijver mol cell endocrinol endometrial cancer based alternative estrogen receptor open access journal specific antibody binding antigen–antibody complexes cancer including types treat endometrial cancer thyroid cancer cells wellcome trust list written informed consent phosphate-buffered saline microscope settings unaltered endometrial cancer cells hormone-blocking drugs hormone replacement therapy ii endometrial cancers major gynaecological cancer american cancer society endometrial cancer taking nanjing medical university primarily oncology-focused prism software package estrogen replacement therapy continuous publishing model tongji university school united states yearly extra-nuclear receptors breast cancer res developing endometrial cancer

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Is the positivity of estrogen receptor or progesterone receptor different between type 1 and type 2 endometrial cancer?
Type I and II endometrial cancers: have they different risk factors?
What does an orphan G-protein-coupled receptor have to do with estrogen?

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Article:
      license:https://creativecommons.org/licenses/by/4.0/
      publisher:
         type:Organization
         name:Oncotarget
         logo:
            type:ImageObject
            url:https://www.oncotarget.com/images/oncotarget-logo-square.png
            width:1200
            height:1200
      dateModified:2017-10-31T12:29:00Z
      mainEntityOfPage:
         type:WebPage
         id:https://www.oncotarget.com/article/18545/text/
      headline:The positivity of G-protein-coupled receptor-30 (GPR 30), an alternative estrogen receptor is not different
      articleSection:Research Papers
      sameAs:https://doi.org/10.18632/oncotarget.18545
      image:https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=viewFile&path%5B%5D=18545&path%5B%5D=59610&path%5B%5D=270607
      datePublished:2017-06-17T00:00:00Z
      author:
            type:Person
            name:Wan, Jiayi
            type:Person
            name:Yin, Yongxiang
            type:Person
            name:Zhao, Min
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            name:Shen, Fang
            type:Person
            name:Chen, Miaoxin
            type:Person
            name:Chen, Qi
Organization:
      name:Oncotarget
      logo:
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         url:https://www.oncotarget.com/images/oncotarget-logo-square.png
         width:1200
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ImageObject:
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      width:1200
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WebPage:
      id:https://www.oncotarget.com/article/18545/text/
Person:
      name:Wan, Jiayi
      name:Yin, Yongxiang
      name:Zhao, Min
      name:Shen, Fang
      name:Chen, Miaoxin
      name:Chen, Qi

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