
DOI . ORG {
}
Title[redir]:
A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis | Oncotarget
Description:
// Yong-Sik Bong 1, * , Shahin Assefnia 1, * , Therese Tuohy 2 , Deborah W Neklason 2 , Randall W Burt 2 , Jaeil Ahn 3 , Paul J Bueno De Mesquita 1 , Stephen W. Byers 1 1 Georgetown-Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University School of Medicine, Washington, DC, United States of America 2 Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States of America 3 Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University School of Medicine, Washington, DC, United States of America * These authors contributed equally to this work Correspondence to: Stephen W, email: [email protected] Keywords: gardner’s syndrome, anal cancer, vitamin D receptor, azoxymethane, colon cancer Received: April 13, 2016 Accepted: October 11, 2016 Published: October 19, 2016 ABSTRACT Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/β-catenin/TCF tumor suppressor pathway. The vitamin D receptor (VDR) is also implicated in cardiovascular and skin diseases as well as in immunity. Activated VDR can indirectly alter β-catenin nuclear localization and directly suppress β-catenin/TCF mediated transcriptional activity. We treated VDR null mice with the carcinogen azoxymethane (AOM) and generated mice bearing a mutated APC (hypomorph) on a VDR null background ( Apc 1638N/+ Vdr −/− ). VDR null mice do not develop GI or extra-colonic tumors but loss of VDR decreased intestinal tumor latency and increased progression to adenocarcinoma in both models. AOM treatment of VDR null mice also caused squamous cell carcinoma of the anus. Although levels and distribution of total or activated β-catenin in the epithelial component of tumors were unaffected by loss of VDR, β-catenin dependent cyclin D1 expression was affected suggesting a direct VDR effect on β-catenin co-activator activity. Extra-colonic mucosa manifestations in Apc 1638N/+ Vdr −/− animals included increased nuclear β-catenin in submucosal stromal cells, spleno- and cardiomegaly and large epidermoid cysts characteristic of the FAP variant, Gardner’s syndrome. Consistent with this, SNPs in the VDR, vitamin D binding protein and CYP24 as well as mutations in APC distal to codon 850 were strongly associated with Gardners syndrome in a cohort of 457 FAP patients, This work suggests that alterations in the vitamin D/VDR axis are important in Gardner’s syndrome, as well as in the etiology of anal cancer.
Matching Content Categories {📚}
- Science
- Health & Fitness
- Education
Content Management System {📝}
What CMS is doi.org built with?
Custom-built
No common CMS systems were detected on Doi.org, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of doi.org audience?
🏙️ Massive Traffic: 50M - 100M visitors per month
Based on our best estimate, this website will receive around 75,489,999 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Doi.org Make Money? {💸}
We don’t know how the website earns money.
The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.
Keywords {🔍}
vdr, vitamin, mice, tumor, cancer, βcatenin, apc, apcnvdr, lesions, cell, extracolonic, fap, apcn, figure, colon, tumors, cells, months, receptor, skin, intestinal, patients, left, syndrome, progression, staining, journal, loss, animals, pathway, cyclin, gene, incidence, mouse, representative, model, colorectal, gardners, activity, increased, genes, upper, sections, cysts, mutation, signaling, ablation, bar, models, polyposis,
Topics {✒️}
reduced vdr/β-catenin interactions anti-active β-catenin antibody β-catenin-related neoplasias found parasite-free animal facility wnt/beta-catenin signalling represses β-catenin signaling activate β-catenin signaling β-catenin target gene mediating β-catenin phosphorylation activated β-catenin signaling cardiac renin-angiotensin systems activated β-catenin occurred avidin/biotin blocking kit biotin-conjugated secondary antibodies inflammation-driven tumor progression regulate beta-catenin proteolysis representative hematoxylin/eosin staining inaugural editorial blood-derived genomic dna regulating β-catenin signaling uk/pathology/protocols/alcblue vdr directly regulates tailed chi-square test extra-colonic mucosa manifestations activated β-catenin results vdr-mediated transcriptional regulation anti-active caspase-3 antibody targeted chain-termination mutation publication alerts subscribe aom-induced tumors revealed open-access journal dedicated increasing dna damage epidermal cysts/keratocanthomas prompted free publication β-catenin activates nuclear β-catenin chemically induced tumorigenesis current opinion total β-catenin levels enhancing wnt signaling familial adenomatous polyposis basal cell carcinomas increased tumor multiplicity/progression beta-catenin crossregulation apc1638n/+vdr−/− mice compared squamous cell carcinoma adenomatous polyposis coli familial polyposis coli apcmin/+vdr−/− animals compared active β-catenin
Schema {🗺️}
Article:
license:https://creativecommons.org/licenses/by/4.0/
publisher:
type:Organization
name:Oncotarget
logo:
type:ImageObject
url:https://www.oncotarget.com/images/oncotarget-logo-square.png
width:1200
height:1200
dateModified:2016-12-06T08:11:12Z
mainEntityOfPage:
type:WebPage
id:https://www.oncotarget.com/article/12768/text/
headline:A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal c
articleSection:Research Papers
sameAs:https://doi.org/10.18632/oncotarget.12768
image:https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=viewFile&path%5B%5D=12768&path%5B%5D=40456&path%5B%5D=191361
datePublished:2016-10-19T00:00:00Z
author:
type:Person
name:Bong, Yong-Sik
type:Person
name:Assefnia, Shahin
type:Person
name:Tuohy, Therese
type:Person
name:Neklason, Deborah W
type:Person
name:Burt, Randall W
type:Person
name:Ahn, Jaeil
type:Person
name:Bueno De Mesquita, Paul J
type:Person
name:Byers, Stephen W.
Organization:
name:Oncotarget
logo:
type:ImageObject
url:https://www.oncotarget.com/images/oncotarget-logo-square.png
width:1200
height:1200
ImageObject:
url:https://www.oncotarget.com/images/oncotarget-logo-square.png
width:1200
height:1200
WebPage:
id:https://www.oncotarget.com/article/12768/text/
Person:
name:Bong, Yong-Sik
name:Assefnia, Shahin
name:Tuohy, Therese
name:Neklason, Deborah W
name:Burt, Randall W
name:Ahn, Jaeil
name:Bueno De Mesquita, Paul J
name:Byers, Stephen W.
Social Networks {👍}(6)
External Links {🔗}(84)
- Get to know what's the income of https://www.oncotarget.com/article/12768/text/
- How much money does https://www.oncotarget.com/article/12768/text/editorial-board/ generate?
- What's the total monthly financial gain of http://oncotarget.msubmit.net?
- How much revenue does https://www.oncotarget.com/article/12768/text/archive/v16/ produce monthly?
- How much money does https://www.oncotarget.com/article/12768/text/archive/ generate?
- What's the financial intake of https://www.oncotarget.com/article/12768/text/scientific-integrity/?
- How much does https://www.oncotarget.com/article/12768/text/editorial-policies/ earn?
- How much does https://www.oncotarget.com/article/12768/text/ethics-statement/ make?
- https://www.oncotarget.com/article/12768/text/collections/'s financial summary
- Learn how profitable https://www.oncotarget.com/article/12768/text/videos/interview/ is on a monthly basis
- Financial intake of https://www.oncotarget.com/article/12768/text/news/pr/
- Find out how much https://www.oncotarget.com/article/12768/text/news/conferences/ earns monthly
- Profit of https://www.oncotarget.com/article/12768/text/search/
- What's the monthly income of https://www.oncotarget.com/article/12768/text/contact/?
- What's the income generated by https://www.oncotarget.com/article/101/ each month?
- What is the monthly revenue of https://www.oncotarget.com/article/12768/text/subscribe/?
- How much does https://cancer.c2pforum.com/ earn?
- What's the monthly money flow for https://www.oncoscience.us/?
- How much does https://www.oncotarget.com/article/12768/text/editorial-policies/#post-publication-promotion net monthly?
- Earnings of https://www.impactjournals.com/
- How much does https://wellcome.org/ make?
- How much does https://www.sspnet.org/ pull in?
- How much revenue does https://www.oncotarget.com/article/12768/text/archive/v7/i49/ generate?
- Learn how profitable https://www.oncotarget.com/article/12768/pdf/ is on a monthly basis
- What's the financial outcome of https://www.oncotarget.com/article/12768/text/javascript:openRTWindow('https://www.oncotarget.com/index.php?journal=oncotarget&page=rt&op=suppFiles&path%5B%5D=12768&path%5B%5D=40456');?
- What's the financial intake of https://www.oncotarget.com/article/12768/text/javascript:openRTWindow('https://www.oncotarget.com/index.php?journal=oncotarget&page=rt&op=captureCite&path%5B%5D=12768&path%5B%5D=40456');?
- What's the financial gain of https://www.oncotarget.com/article/12768/text/mailto:%62%79%65%72%73%73@%67%65%6f%72%67%65%74%6f%77%6e.%65%64%75?
- What's the total monthly financial gain of https://www.oncotarget.com/article/12768/text/mailto:[email protected]?
- How much profit is https://www.oncotarget.com/article/12768/text/#R1 making per month?
- What is the earnings of https://www.oncotarget.com/article/12768/text/#R2?
- How much money does https://www.oncotarget.com/article/12768/text/#R3 make?
- What's the monthly income of https://www.oncotarget.com/article/12768/text/#R4?
- What is the monthly revenue of https://www.oncotarget.com/article/12768/text/#R5?
- Monthly income for https://www.oncotarget.com/article/12768/text/#R6
- How much does https://www.oncotarget.com/article/12768/text/#R7 generate monthly?
- How much does https://www.oncotarget.com/article/12768/text/#R8 gross monthly?
- What is the monthly revenue of https://www.oncotarget.com/article/12768/text/#R9?
- How much money does https://www.oncotarget.com/article/12768/text/#R10 make?
- Get to know what's the income of https://www.oncotarget.com/article/12768/text/#R12
- How much does https://www.oncotarget.com/article/12768/text/#R13 net monthly?
- How much revenue does https://www.oncotarget.com/article/12768/text/#R14 bring in?
- How much does https://www.oncotarget.com/article/12768/text/#R15 net monthly?
- Get to know what's the income of https://www.oncotarget.com/article/12768/text/#R16
- What are the earnings of https://www.oncotarget.com/article/12768/text/#R20?
- How much profit is https://www.oncotarget.com/article/12768/text/#R21 making per month?
- https://www.oncotarget.com/article/12768/text/#R22's financial summary
- Check the income stats for https://www.oncotarget.com/article/12768/text/#R23
- What's the profit of https://www.oncotarget.com/article/12768/text/#R24?
- Income figures for https://www.oncotarget.com/article/12768/text/#R25
- How much does https://www.oncotarget.com/article/12768/text/#F1 earn?
- How much does https://www.oncotarget.com/article/12768/text/#F2 net monthly?
- Financial intake of https://www.oncotarget.com/article/12768/text/#R26
- Earnings of https://www.oncotarget.com/article/12768/text/#R27
- How much does https://www.oncotarget.com/article/12768/text/#R28 generate monthly?
- Learn about the earnings of https://www.oncotarget.com/article/12768/text/#R29
- How much income is https://www.oncotarget.com/article/12768/text/#R30 earning monthly?
- How much revenue does https://www.oncotarget.com/article/12768/text/#R31 bring in?
- Explore the financials of https://www.oncotarget.com/article/12768/text/#R32
- Get to know https://www.oncotarget.com/article/12768/text/#R33's earnings
- How much income is https://www.oncotarget.com/article/12768/text/#F3 earning monthly?
- How much does https://www.oncotarget.com/article/12768/text/#R34 pull in monthly?
- https://www.oncotarget.com/article/12768/text/#R35 income
- What's the income generated by https://www.oncotarget.com/article/12768/text/#R36 each month?
- What's the income generated by https://www.oncotarget.com/article/12768/text/#F4 each month?
- How much revenue does https://www.oncotarget.com/article/12768/text/#R37 generate?
- What's the financial outcome of https://www.oncotarget.com/article/12768/text/#R38?
- How much money does https://www.oncotarget.com/article/12768/text/#R39 generate?
- How much revenue does https://www.oncotarget.com/article/12768/text/#R40 bring in?
- Monthly income for https://www.oncotarget.com/article/12768/text/#R41
- What's the income generated by https://www.oncotarget.com/article/12768/text/#T1 each month?
- Income figures for https://www.oncotarget.com/article/12768/text/#T2
- Learn about the earnings of https://www.oncotarget.com/article/12768/text/#T3
- What's the financial gain of https://www.oncotarget.com/article/12768/text/#R42?
- What's the profit of https://www.oncotarget.com/article/12768/text/#R43?
- How much does https://www.oncotarget.com/article/12768/text/#R44 earn?
- https://www.oncotarget.com/article/12768/text/#R45 income
- How much profit does https://www.oncotarget.com/article/12768/text/#R46 make?
- How much revenue does https://www.oncotarget.com/article/12768/text/#R47 generate?
- Learn about the earnings of https://www.oncotarget.com/article/12768/text/#R48
- What is the earnings of https://www.oncotarget.com/article/12768/text/#R49?
- What's the financial outcome of https://www.oncotarget.com/article/12768/text/#R50?
- What's https://www.oncotarget.com/article/12768/text/#R51's gross income?
- https://www.oncotarget.com/article/12768/text/#R52's total income per month
- How much cash flow does https://creativecommons.org/licenses/by/4.0/ have monthly?
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
- Google Universal Analytics
Libraries {📚}
- Foundation
- jQuery
Emails and Hosting {✉️}
Mail Servers:
- mx.zoho.eu
- mx2.zoho.eu
- mx3.zoho.eu
Name Servers:
- josh.ns.cloudflare.com
- zita.ns.cloudflare.com
CDN Services {📦}
- Cloudflare