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Title[redir]:
Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome | PLOS Pathogens
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Keywords {π}
caspase, inflammasome, pneumophila, nlrc, naipnlrcasc, macrophages, gasdermind, activation, data, plos, view, cookies, article, replication, casp, activated, susceptible, cookie, enable, mascarenhas, flagellin, triggers, restriction, bacterial, mice, recruited, deficient, cell, death, information, publish, research, inhibition, cerqueira, pereira, castanheira, fernandes, manin, legionella, legionnaires, disease, infection, pathway, bacteria, process, dependent, naip, asc, cells, found,
Topics {βοΈ}
naip5/nlrc4/asc inflammasome media inquiries plos cytosolic flagellin triggers supporting information files favor host responses download citation email naip/nlrc4 inflammasome enable caspase-8 activation affects people worldwide innate immune cells flagellin-positive bacteria cookie preference center save selected preferences competing interests exist nlrc4 activate caspase-1 casp1/11-/- cells culminated pneumophila replication compared wild-type macrophages cookie policy cell death plos pathog 13 research fellow top back cookies plos asc/casp1/11-/ caspase-8 activation bacterial flagellin original author competing interests cookie preferences caspase-1/11-independent nlrc4-/- mice nlrc4-dependent pneumophila replication pathogenic bacteria authors atypical pneumophila pneumophila demonstrated bacterial replication gram-negative flagellated bacterium legionnairesβ disease feature supports data suggest causative agent clinical importance inhibit components steven seifert terms permits unrestricted
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