DOI . ORG {
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Detected CMS Systems:
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We began analyzing https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005871, but it redirected us to https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005871. The analysis below is for the second page.
Title[redir]:
No title found...
Description:
Author Summary While numerous studies have addressed the response to primary virus infections, we know relatively little about the interplay between recurrent and/or persistent infections and the memory humoral immune response on professional antigen-presenting cells. Immune complexed-adenoviruses are present in patients suffering from adenoviremia. In addition to the impact of HAdV infections on healthy and immune suppressed hosts, humoral immunity hampers the use of human adenovirus vectors during gene transfer. Our study shows that anti-adenovirus humoral immunity engages an innate immune response to cause pyroptosis of antigen-presenting cells. The downstream effects of this cells death is unknown and may impact the stimulation and differentiation of T cells into an inflammatory phenotype that may be associated with the complications during adenovirus disease and adenovirus vector use. Our study generates insight into how humoral immunity shapes the response to adenoviruses in healthy and immune-compromised individuals, during human adenovirus-based vaccine use, and during antibody therapy.
Title[redir]:
No title found...
Description:
Author Summary While numerous studies have addressed the response to primary virus infections, we know relatively little about the interplay between recurrent and/or persistent infections and the memory humoral immune response on professional antigen-presenting cells. Immune complexed-adenoviruses are present in patients suffering from adenoviremia. In addition to the impact of HAdV infections on healthy and immune suppressed hosts, humoral immunity hampers the use of human adenovirus vectors during gene transfer. Our study shows that anti-adenovirus humoral immunity engages an innate immune response to cause pyroptosis of antigen-presenting cells. The downstream effects of this cells death is unknown and may impact the stimulation and differentiation of T cells into an inflammatory phenotype that may be associated with the complications during adenovirus disease and adenovirus vector use. Our study generates insight into how humoral immunity shapes the response to adenoviruses in healthy and immune-compromised individuals, during human adenovirus-based vaccine use, and during antibody therapy.
Matching Content Categories {📚}
- Science
- Education
- Health & Fitness
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Doi.org utilizes WORDPRESS.
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What is the average monthly size of doi.org audience?
🏙️ Massive Traffic: 50M - 100M visitors per month
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Keywords {🔍}
article, view, google, scholar, ichadv, hadvc, cells, pmid, pubmedncbi, modcs, membrane, aim, fig, cell, inflammasome, modc, human, adenovirus, nlrp, ivig, induce, activation, capsid, integrity, ichadvs, dna, hadv, tlr, immune, protein, ilβ, loss, levels, secretion, caspase, response, formation, maturation, cytometry, infection, data, found, plos, incubated, flow, dendritic, results, death, release, monocytes,
Topics {✒️}
cell biology approaches health standards poly-l-lysine-coated coverslips capable autoimmune diseases plos pathog 12 plos pathog cookies plos plos ifn-alpha enhances cross-presentation systems cias1/cryopyrin/pypaf1/nalp3/ caterpiller 1 ic-hadv-mediated membrane permeabilization myd88-nf-κb signaling pathways nf-κb suppressive properties demonstrating disrupted membranes hadv-c5 pre-existing immunity tumor necrosis factor-alpha promote t-cell responses caspase-dependent il-1β secretion transduced thp-1-asc-gfp cells ic-hadv-mediated modc death differentiated thp-1-asc-gfp cells tnf-alpha mediates sensitization incubated thp-1-asc-gfp dc fam-yvad-fmk flica enter ic-hadv-challenged modcs lentivirus-mediated shrna knockdown supporting information files ic-adl40q versus ic-hadv anti-adv th17 cd4 caspase-1-processed cytokines il-1beta anti-hexon-ab-depleted serum pre-existing humoral immunity human ad5-specific cd4 hadv-c5 harboring mutations lentiviral-mediated shrna knockdown hadv-c5 capsid proteins ad5/hiv-1 vaccine candidate provide life-long protection c-terminal hin200-domain detect larger aggregates inhibit il-1β secretion fluorescently-labelled secondary antibody thp-1-derived dc expressing lose intracellular proteins long-lasting cross-presentation immune-complexed hadv-c5 ~4 hadv-c5 particles/complex ic-hadv gain access hrp-conjugated secondary antibodies
Questions {❓}
- Pyroptosis: pro-virus or pro-host?
- The interferon response to intracellular DNA: Why so many receptors?
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