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Author Summary T-cell immune response is regulated by a variety of molecules known as co-inhibitory receptors. The over expression of co-inhibitory receptors has been observed in several chronic viral infections such as HIV disease, and is found to be associated with severe T-cell dysfunction. Recent studies have demonstrated that the co-expression of several co-inhibitory receptors correlated with greater impairment of CD8 T cells. However, the relative contribution of individual co-inhibitory receptors to the regulation of T-cell functions remains unclear. In order to shed light on these issues, we have evaluated the influence of the expression of 3 major co-inhibitory receptors such as PD-1, 2B4 and CD160 on CD8 T-cell functions such as proliferation, cytokines production and expression of cytotoxic granules. We demonstrate that CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression and that the blockade of CD160 signaling may partially restore CD8 T-cell functions.
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Keywords {🔍}
cells, tcell, expression, bcdpd, proliferation, populations, virusspecific, capacity, coinhibitory, article, view, google, scholar, fig, significantly, flow, molecules, data, ebv, blockade, signaling, cmv, expressing, representative, perforin, compared, mabs, reduced, vivo, anticd, stained, andor, population, min, molecule, profiles, cell, assessed, image, plos, cytometric, cytometry, cumulative, showed, red, statistical, immunol, differentiation, significance, functional,
Topics {✒️}
anti-cd3/anti-cd28 magnetic beads leukocyte biology 87 global cytokine profiles 2b4+cd160+pd-1− virus-specific cd8 2b4+cd160+pd-1+ virus-specific cd8 2b4−cd160−pd-1+ virus-specific cd8 sorted virus-specific 2b4+cd160+pd-1+ cd8 t-cell population hvem/light/btla/cd160 cosignaling pathways cd8 t-cell populations distinct t-cell populations plos pathog 10 plos pathog 8 plos pathog 9 plos pathog 6 cookies plos block cd160/cd160-ligand signaling blocking anti-pd-l1/2 mabs virus-specific 2b4+cd160+pd-1+ cd8 t-cell proliferation cd8 t-cell stimulations cd8 t-cell functions cd8 t-cell subset open-access article distributed cd8 t-cell responses inducible t-cell costimulator t-cell responses depends cd8 t-cell differentiation severe t-cell dysfunction cd8 t-cell expression untreated virus-specific cd8 a-cd3/cd28 coated mabs influenza systems diseases virus-specific cd8 expressing t-cell populations autologous cd8-depleted pbmcs proliferating cfselow cd8 cd160/cd160-ligands signaling blockade cd8 t-cells specific dominant 2b4+cd160−pd-1+ predominant 2b4+cd160−pd-1+ pd-1/pd-l1/2 pathway pd-1/pd-l1 blockade foxp3 fixation/permeabilization kit blocking anti-cd160 abs polyfunctional antigen-specific cd8 anti-pd-l1/2 mabs original author
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