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Author Summary HIV infection is widely known to cause generalized immune activation and immune exhaustion ultimately leading to HIV disease progression. Several studies have suggested over the years that the accumulation of inhibitory signalling proteins on the surface of responding cells is linked to immune exhaustion in HIV. It has become paramount to distinguish functionally exhausted CD8 T cells from activated HIV-specific CD8 T cells because both cell types have different fates. Using specific cell surface markers, we were able to identify these different cell types and show that HIV-infected patients accumulate dysfunctional CD8 T cells over time. Importantly, we show that this dysfunction is reversible.
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Keywords {🔍}
cells, cell, hivspecific, hiv, article, view, expression, google, scholar, infection, figure, cmv, subsets, sppd, chronic, results, αcd, chi, activation, compared, frequencies, subjects, functional, cdpd, subset, significantly, cytokine, levels, hvem, viral, exhaustion, molecules, frequency, function, expressing, hivinfected, exhausted, blocking, showed, plos, analysis, mfi, observed, gene, coexpression, dysfunction, upregulated, ifnγ, tnfα, ahi,
Topics {✒️}
computational biology solutions computational biology montreal health center plos pathogens 8 global molecular network plos pathog 6 plos pathog 5 cookies plos health system biology open-access article distributed contributed reagents/materials/analysis tools chronic viral infections regulating acute infections multiparametric flow cytometry amine-reactive viability dye pd-1/pd-l1 pathway led original author cytokines sp-pd-1 hiv-specific cd8 αifn-γ pe-cy7 systems sp-cd160 hiv-specific cd8 flow cytometry pd-1/pd-l1 blockade suggesting cmv-specific mhc class restoring hiv-specific cd8 cytomegalovirus-specific human cd8 gene array results intrahepatic hcv-specific cd8 hiv-infected patient stimulated viremic hiv-infected subjects gene expression signature gene expression analysis dysfunctional hiv-specific cd8 memory hiv-specific cd8 tumor antigen-specific cd8+ activated hiv-specific cd8 hiv peptide-specific stimulation increased hiv-specific cd8 pd-1identified dysfunctional cd8 sp-pd-1 subsets clustered lymphocyte escape variants αhla-dr apc-cy7 exhausted lcmv-specific cd8 hiv tetramer-specific response surrogate-replacement policy cytometry-related experiments αpd-l1 pe-cy7 hiv-specific dp cd8
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