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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Questions
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051331, but it redirected us to https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051331. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain. This domain mediates interactions with the highly similar Caf1a (CNOT7) and Caf1b (CNOT8) catalytic subunits of the Ccr4-Not deadenylase complex. BTG/TOB proteins have anti-proliferative activity: knockdown of BTG/TOB can result in increased cell proliferation, whereas over-expression of BTG/TOB leads to inhibition of cell cycle progression. It was unclear whether the interaction between BTG/TOB proteins and the Caf1a/Caf1b deadenylases is necessary for the anti-proliferative activity of BTG/TOB. To address this question, we further characterised surface-exposed amino acid residues of BTG2 and TOB1 that mediate the interaction with the Caf1a and Caf1b deadenylase enzymes. We then analysed the role of BTG2 and TOB1 in the regulation of cell proliferation, translation and mRNA abundance using a mutant that is no longer able to interact with the Caf1a/Caf1b deadenylases. We conclude that the anti-proliferative activity of BTG/TOB proteins is mediated through interactions with the Caf1a and Caf1b deadenylase enzymes. Furthermore, we show that the activity of BTG/TOB proteins in the regulation of mRNA abundance and translation is dependent on Caf1a/Caf1b, and does not appear to require other Ccr4-Not components, including the Ccr4a (CNOT6)/Ccr4b (CNOT6L) deadenylases, or the non-catalytic subunits CNOT1 or CNOT3.

Matching Content Categories {📚}

  • Science
  • Education
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?


Doi.org is powered by WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

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Keywords {🔍}

btg, tob, cells, cell, activity, expression, mrna, article, btgtob, view, google, scholar, cnot, proteins, figure, deadenylase, knockdown, proliferation, cafa, mcf, cafb, reporter, antiproliferative, interaction, complex, amino, ccrnot, results, protein, cafacafb, subunits, interactions, transfected, deadenylases, levels, recruitment, transfection, domain, acid, plos, sirna, plasmids, reduced, enzymes, utr, control, observed, gene, carried, error,

Topics {✒️}

plos genet 8 cookies plos large c-terminal regions plos open-access article distributed small deletions contributed reagents/materials/analysis tools coding regions small amounts methods plasmid dna amino acid substitution reporter plasmid prl-5boxb b-cell translocation gene-2 plasmid pcdna6/tr tis21/pc3/btg1/tob family beta-glo assay system original author rna-binding proteins amino acid substitutions plasmid pci-λn [39] inappropriate rag-mediated recombination pc3/btg/tob family create plasmid pcdna4 gal4-activation domain-caf1a/caf1b amino acid residues pgal4-bd cam plasmids gal4 dna-binding domain rna tethering assays human btg/tob family anti-proliferative protein tob vector pgal4-bd cam primers rt-hrl fw btg/tob proteins sequester btg/tob family members ras-mediated cell proliferation ha-epitope tag fused bbsrc grant bb/002338x/1 genome-wide expression data antiproliferative p53-dependent component gal4ad-caf1a/gal4ad-caf1b increased anti-proliferative activity sds-page loading buffer total rna isolated ha-btg2 cdna fragment btg/tob proteins results plasmids pcmv5-ha-btg2 stable cell lines plasmids expressing λn-btg2 amino acid c-terminal region

Questions {❓}

  • Tirone F (2001) The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?
  • Unique or Overlapping Roles of the BTG/TOB Proteins in the Regulation of Cell Proliferation?

Social Networks {👍}(3)

External Links {🔗}(200)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

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Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Cloudflare
  • Crossref

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