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Purpose The purpose of this study was to explore the risk factors for breast cancer and establish the expression rate of IGF-2 in female patients. Methods A case control study with 500 people in case group and 500 people in control group. A self-administered questionnaire was used to investigate risk factors for breast cancer. All cases were interviewed during a household survey. Immune-histochemical method was used to inspect the expression of IGF-2 in different tissues (benign breast lesions, breast cancer and tumor-adjacent tissue). Results Multivariate adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. High body mass index (OR = 1.012,95%CI = 1.008–1.016), working attributes (OR = 1.004, 95%CI = 1.002 = 1.006), long menstrual period (OR = 1.007, 95%CI = 1.005–1.009), high parity OR = 1.003, 95%CI = 1.001–1.005) , frequent artificial abortion (OR = 1.004, 95%CI = 1.001–1.005), family history of cancer (OR = 1.003, 95%CI = 1.000–1.005), period of night shift (OR = 1.003, 95%CI = 1.001–1.006), live in high risk environment (OR = 1.005, 95%CI = 1.002–1.008), and family problems (OR = 1.010, 95%CI = 1.005–1.014) were associated with increased risk for breast cancer. In this study, good sleeping status, positive coping strategies, subjective support, and utility degree of social support were associated with reduced risk for breast cancer (OR = 0.998, 0.997, 0.985, 0.998 respectively; 95%CI = 0.996–1.000, 0.994–1.000, 0.980–0.989, 0.996–1.000, respectively). In benign breast lesions, breast cancer and tumor-adjacent tissue, IGF-2 was mainly expressed in the cytoplasm, but its expression rate was different (p<0.05). Conclusions The incidence of breast cancer is a common result of multiple factors. IGF-2 is involved in the development of breast cancer, and its expression varies in different tissues (benign breast lesions, breast cancer and tumor-adjacent tissue).
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Keywords {🔍}
cancer, breast, igf, risk, cases, expression, article, view, study, google, scholar, women, factors, growth, insulinlike, invasive, factor, development, plos, receptor, insulin, tissue, high, age, years, benign, controls, tissues, health, image, body, tumor, research, rate, patients, night, increased, support, data, protein, significant, table, bmi, estrogen, wuhan, lesions, regression, positive, higher, binding,
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cookies plos plos breast diseases 17 mental illness psychosomatic medicine 62 body mass index open-access article distributed major public hospitals contributed reagents/materials/analysis tools reproductive health variables molecular epidemiology nurses' health study epidemiology studies benign breast lesions low-fat dietary pattern health workers health study original author breast tumors wilms tumors breast benign lesion breast cancer-adjacent tissue benign breast group tumors due activates estrogen receptor-α anti-igf2 antibody overnight long-term night shift invasive breast cancer invasive ductal carcinoma igf-1signal transduction system regular body exercises body produces melatonin igf-2 activates er-α constitutive igf1/igf2 stimulation logistic regression model estrogen receptor-alpha gene tumors unconditional logistic regression logistic regression mode investigate risk factors high-risk factors family planning methods breast cancer risk metastatic breast cancer human breast cancer breast cancer cells unconditional regression model terms menopausal status low cortisol concentrations breast cancer tissue
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