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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017876, but it redirected us to https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017876. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Background Cancer/testis (CT) antigens are protein antigens normally expressed only in germ cells of testis, and yet are expressed in a proportion of a wide variety of human cancers. CT antigens can elicit spontaneous immune responses in cancer patients with CT-positive cancers, and CT antigen-based therapeutic cancer vaccine trials are ongoing for “CT-rich” tumors. Although some previous studies found breast cancer to be “CT-poor”, our recent analysis identified increased CT mRNA transcripts in the ER-negative subset of breast cancer. Methodology/Principal Findings In this study, we performed a comprehensive immunohistochemical study to investigate the protein expression of eight CT genes in 454 invasive ductal carcinomas, including 225 ER/PR/HER2-negative (triple-negative) carcinomas. We found significantly more frequent expression of all eight CT antigens in ER-negative cancers, and five of them—MAGEA, CT7, NY-ESO-1, CT10 and CT45, were expressed in 12–24% of ER-negative cancers, versus 2–6% of ER-positive cancers (p<0.001 to 0.003). In comparison, GAGE, SAGE1 and NXF2 were only expressed in 3–5% of ER-negative and 0–2% of ER-positive cancers. ER-negative cancers were also more likely to simultaneously co-express multiple CT antigens, with 27% (34/125) of ER-negative, CT-positive tumors expressing three or more CT antigens. HER2 status had no consistent effect on CT expression, and triple-negative carcinomas showed similar frequencies of MAGEA and NY-ESO-1 expression as ER-negative/HER2-positive carcinomas. More frequent CT expression was also found in tumors with higher nuclear grade (p<0.001 to p = 0.01) and larger in size (>2 cm). Conclusions/Significance CT antigens are preferentially expressed in hormone receptor-negative and high-grade breast cancer. Considering the limited treatment options for ER/PR/HER2 triple-negative breast cancer, the potential of CT-based immunotherapy should be explored.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is doi.org built with?


Doi.org relies on WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

It is strange but we were not able to detect any theme on the page.

What WordPress plugins does this website use?

It is strange but we were not able to detect any plugins on the page.

Keywords {🔍}

cancer, expression, breast, antigens, nyeso, magea, cases, ernegative, positive, article, tumors, view, google, scholar, nuclear, antigen, expressed, tumor, erher, staining, cancers, chen, study, showed, cells, series, image, analysis, erpositive, status, plos, cytoplasmic, protein, triplenegative, immunohistochemical, frequency, group, patients, gage, antibody, negative, carcinomas, higher, antibodies, cancertestis, found, including, nxf, data, versus,

Topics {✒️}

formalin-fixed paraffin-embedded tissues y-tc y-yc sah cookies plos antigen-retrieval techniques plos renal cancer colorectal cancer open-access article distributed laboratory medicine cd79a+ plasmacytic/b-cell infiltration immunohistochemistry er/pr/her2 triple-negative subgroup contributed reagents/materials/analysis tools er/pr/her2 triple-negative cases high-risk node-negative disease gov/cancertopics/treatment/breast �cancer-testis” antigen ny-eso-1 including 225 er/pr/her2-negative ct-based cancer vaccine er-negative/her2-positive carcinomas multiple cancer/testis antigens triple-negative breast cancer high-grade breast cancer er-negative tumors individually er-negative breast cancer original author high-grade breast cancers her2 triple-negative carcinoma ct-positive breast cancer ct-positive tumors expressing cancer vaccine trials er-negative breast cancers er-negative cancer expressed cell-mediated immune responses introduction cancer/testis main treatment option er-positive tumors expressed ct antigen-based immunotherapy anti-her2 monoclonal antibody cancer/testis antigen ct45 ny-eso-1 positive rate additional treatment options �ct-rich” tumor type pure cytoplasmic staining recombinant ny-eso-1 protein ny-eso-1 antigen expression ucsf medical center anti-mage-1 antibody 6c1 ny-eso-1 positive cases limited treatment options

Social Networks {👍}(3)

External Links {🔗}(166)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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