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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015495, but it redirected us to https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015495. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness in humans. Previously, excessive activation of enzymes belonging to the poly-ADP-ribose polymerase (PARP) group was shown to be involved in photoreceptor degeneration in the human homologous rd1 mouse model for RP. Since there are at least 16 different PARP isoforms, we investigated the exact relevance of the predominant isoform - PARP1 - for photoreceptor cell death using PARP1 knock-out (KO) mice. In vivo and ex vivo morphological analysis using optic coherence tomography (OCT) and conventional histology revealed no major alterations of retinal phenotype when compared to wild-type (wt). Likewise, retinal function as assessed by electroretinography (ERG) was normal in PARP1 KO animals. We then used retinal explant cultures derived from wt, rd1, and PARP1 KO animals to test their susceptibility to chemically induced photoreceptor degeneration. Since photoreceptor degeneration in the rd1 retina is triggered by a loss-of-function in phosphodiesterase-6 (PDE6), we used selective PDE6 inhibition to emulate the rd1 situation on non-rd1 genotypes. While wt retina subjected to PDE6 inhibition showed massive photoreceptor degeneration comparable to rd1 retina, in the PARP1 KO situation, cell death was robustly reduced. Together, these findings demonstrate that PARP1 activity is in principle dispensable for normal retinal function, but is of major importance for photoreceptor degeneration under pathological conditions. Moreover, our results suggest that PARP dependent cell death or PARthanatos may play a major role in retinal degeneration and highlight the possibility to use specific PARP inhibitors for the treatment of RP.

Matching Content Categories {📚}

  • Science
  • Education
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?


Doi.org is powered by WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

It is strange but we were not able to detect any theme on the page.

What WordPress plugins does this website use?

It is strange but we were not able to detect any plugins on the page.

Keywords {🔍}

parp, cell, death, article, view, retinal, google, scholar, photoreceptor, sem, retina, degeneration, cells, activity, cgmp, mouse, animals, pde, zaprinast, onl, fig, positive, plos, par, mice, activation, accumulation, dna, retinae, polyadpribose, inhibition, photoreceptors, vivo, induced, situation, treatment, tunel, function, analysis, excessive, polymerase, showed, major, normal, previously, shown, medium, beta, levels, protein,

Topics {✒️}

retinitis pigmentosa models health-f2-2008-200234 cookies plos plos health experimental systems retinitis pigmentosa contributed reagents/materials/analysis tools mitochondrial apoptosis-inducing factor open-access article distributed apoptosis-inducing factor optical coherence tomography antagonist poly-adp-ribose-glycohydrolase optic coherence tomography inherited neurodegenerative diseases mouse models studied animal models dimensional b-scan recorded pancreatic beta-cell destruction photoreceptors remained open caspase-independent cell death original author spectralis™ hra+oct device biotin-avidin blocking kit neurodegenerative diseases [11] neurodegenerative diseases concentration dependent manner cell death induced parp1 gene knock induced photoreceptor degeneration photoreceptor degeneration induced photoreceptor cell death parp1 ko photoreceptors inherited retinal degeneration poly-adp-ribose polymers mouse retina explants single flash ergs cell death mechanism c3h mouse retina retinal degeneration starts inherited photoreceptor degeneration cell death markers larger numbers figures citation vertebrate phototransduction cascade pde6 inhibitor zaprinast image enhancements affecting retinal function selective cell death photoreceptor cell bodies

Social Networks {👍}(3)

External Links {🔗}(179)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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