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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Questions
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000108, but it redirected us to https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000108. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Author SummaryIn the present study, we demonstrate for the first time a pro-diabetogenic function of the ERβ. Our experiments indicate that ERβ impairs insulin sensitivity and glucose tolerance in mice challenged with a high fat diet (HFD). Loss of ERβ, studied in ERβ -/- mice (βERKO mice), results in increased body weight gain and fat deposition under HFD-treatment. Conversely, absence of ERβ averted accumulation of triglycerides and preserved regular insulin signaling in liver and skeletal muscle. This observation was associated with improved whole-body insulin sensitivity and glucose tolerance. Increased adipose tissue mass in the presence of improved insulin sensitivity and glucose tolerance is usually observed under chronic stimulation of the nuclear hormone receptor PPARγ. In consonance, we show that activation of PPARγ was markedly induced in gonadal fat from βERKO mice and blockade of adipose PPARγ signaling by antisense oligonucleotide injection reversed the metabolic phenotype. Moreover, our cell culture experiments indicate that ERβ is a negative regulator of ligand-induced PPARγ activity in vitro. Finally, we identify SRC1 and TIF2 as key players in the ERβ-PPARγ interaction. In summary, the present study demonstrates that ERβ impairs insulin and glucose metabolism, which may, at least in part, result from a negative cross-talk with adipose PPARγ.

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is doi.org built with?


Doi.org employs WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

It is strange but we were not able to detect any theme on the page.

What WordPress plugins does this website use?

It is strange but we were not able to detect any plugins on the page.

Keywords {🔍}

pparγ, mice, βerko, erβ, insulin, figure, fat, glucose, article, view, adipose, google, scholar, activity, expression, metabolic, tissue, receptor, increased, signaling, cells, data, hfdfed, gonadal, estrogen, weight, performed, tif, activation, analysis, target, preadipocytes, src, tolerance, liver, nuclear, body, improved, sensitivity, treated, image, experiments, gene, adiponectin, control, pioglitazone, interaction, binding, hfd, muscle,

Topics {✒️}

estrogen-receptor biology plos genet 4 cookies plos ice-cold chloroform/methanol/water mixture peroxisome proliferator-activated receptor/retinoid developmental biology tse systems cnrs/inserm/université louis pasteur models real-time rt-pcr analysis open-access article distributed erβ-specific agonist propylpyrazole-triol real-time rt-pcr contributed reagents/materials/analysis tools pparγ-dependent gene expression mouse-adiponectin elisa insulin signaling/glucose metabolism delta af1-erβ-psg5 3t3-l1 preadipocytes showed insulin-induced glucose uptake insulin metabolism supporting nh2-terminal af1 domain oestrogen receptor-alpha plays values represent means±sem hormone receptor-dependent pathophysiology target gene expression lipid-activated transcription factor female c57bl/6j mice ligand-dependent pparγ activity original author pparγ-induced transcriptional activation ligand-induced pparγ activity ppar gamma ppar gamma 2 high-affinity pparγ agonists mouse model pparγ-mediated transcriptional activity mutual signaling cross-talk secondary horseradish-conjugated antibodies ligand-mediated pparγ transcription erβ-specific ligand diarylpropionitrile real-time pcr erβ-selective agonists intended agonist-stimulated ppre-activity 3t3-l1 preadipocyte differentiation untransfected 3t3-l1 cells adipose tissue remodeling muscular insulin signaling attenuated fatty acid quantitative pcr reactions

Questions {❓}

  • Maxwell GM, Nobbs S, Bates DJ (1987) Diet-induced thermogenesis in cafeteria-fed rats: a myth?

Social Networks {👍}(3)

External Links {🔗}(211)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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