
DOI . ORG {
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Secondary structure plays an important role in determining the function of noncoding RNAs. Hence, identifying RNA secondary structures is of great value to research. Computational prediction is a mainstream approach for predicting RNA secondary structure. Unfortunately, even though new methods have been proposed over the past 40 years, the performance of computational prediction methods has stagnated in the last decade. Recently, with the increasing availability of RNA structure data, new methods based on machine learning (ML) technologies, especially deep learning, have alleviated the issue. In this review, we provide a comprehensive overview of RNA secondary structure prediction methods based on ML technologies and a tabularized summary of the most important methods in this field. The current pending challenges in the field of RNA secondary structure prediction and future trends are also discussed.
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Keywords {🔍}
rna, structure, secondary, article, view, google, scholar, pmid, pubmedncbi, prediction, methods, model, structures, base, mlbased, sequence, data, based, folding, energy, approach, parameters, pairs, models, nucleic, colleagues, free, method, res, biol, acids, learning, score, rnas, algorithm, predict, plos, sequences, training, accuracy, proposed, thermodynamic, performance, pseudoknots, bioinformatics, predicting, analysis, large, set, traditional,
Topics {✒️}
plos comput biol plos biol human diseases cookies plos plos public benchmark datasets fundamental biology biology fields molecular biology global folding complex tertiary structure complex probabilistic models stochastic context-free grammars free energy–refining approach larger secondary structure k-nearest neighbor classifiers free energy–based models global rna-interference-based therapeutics data-driven ml-based methods microrna-disease associations based k-nearest neighbor model repeat rna-mbnl1 interaction stem-loop rna structures image processing fields family-wise cross-validation hybridization thermodynamics wet lab–based approaches ml-based prediction process large-scale automated annotation free energy–focused approach sars-cov-2 virus responsible traditional ml-based models existing shape-directed method traditional score-based methods transformer-based deep model minimum/maximum total score watson–crick base pairs watson-crick base pairs expanded nearest-neighbor model secondary structure motifs computational predicting approaches computational prediction methods rna free energy tertiary base-pairing prediction context-free grammars traditional score-based approach free energy parameter free energy based secondary structure prediction
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