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Title[redir]:
Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++ | PLOS Computational Biology
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Keywords {🔍}
gerp, sequences, functional, elements, genome, human, constraint, constrained, plos, view, cookies, article, identify, sequence, approach, cookie, fraction, selective, davydov, information, multiple, tool, evolutionary, author, sites, work, supported, publish, search, identifying, high, goode, sirota, cooper, sidow, batzoglou, comparative, bottomup, scores, positions, alignment, scoring, nucleotide, methods, set, based, higher, longer, genomics, evolution,
Topics {✒️}
open-access article distributed element-level constraint scores media inquiries plos download citation email detecting constrained elements defining constrained elements functional sequence elements position-specific scoring candidate element breakpoints longer constrained elements multiple sequence alignment identify functional elements perform essential functions protein-coding exons show fewer substitutions computing constraint scores gerp++ results cookie preference center save selected preferences identify functional sequences dynamic programming approach �comparative genomics” approach competing interests exist author summary original author cookie policy methods gerp++ identifies sites information cookies plos multiple alignment top back predicted elements evolutionary constraint functional sequences individual positions competing interests cookie preferences regulatory sequences genome sequences authors selective constraint high fraction human genome exhibit evidence statistical significance higher fraction noncoding rnas discernible function major challenge
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