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A novel genetic tool for inducing chromosomal imbalance in fruit flies in an acute and time-controlled manner reveals that the brain is the most sensitive tissue when it comes to coping with abnormal karyotypes during development.
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Keywords {๐}
aneuploidy, cohesin, cell, cells, hours, article, view, fig, google, scholar, pmid, pubmedncbi, ahs, brain, mitotic, nbs, loss, induction, drosophila, larvae, aneuploid, flies, brains, response, tissue, number, rad, development, chromosome, heat, system, central, shock, stress, protein, rescue, tissues, thirdinstar, cleavage, neural, pubmed, pmcid, pmcpmc, stem, ael, induced, developmental, adult, mitosis, control,
Topics {โ๏ธ}
stem cell biology plos biol 17 plos biol cookies plos metabolic health health chromosomal proteins genetics flies systems represent biology constitutively express uas-rad21-wt-myc double strand break tobacco etch virus apparently normal-sized organ live-cell imaging reveals cyclin-dependent kinase inhibitor cy5-acgggaccagtacgg dna probes drosophila melanogaster biological-image analysis c-myc gene product nuclear envelope breakdown wing disc areas sister chromatid cohesionโimportance neural stem-cell pool cell-cycle profile evaluation original author relative p53-positive signal 5-ฮผm-thick sequential sections tobacco etch virusuas neural stem-cell population created survival curves relative dap-positive signal v5 antibody evidences chromosome-specific missegregation approaches neural stem-cell genome multiple stress-response pathways cell-cycle arrest/senescence prevent chromosome mis-segregation studying cell proliferation system-level feedback stem-cell identity measured increased stem-cell proliferation holds sister chromatids stable cohesin-chromatin interaction live-imaging cohesin profiles heat-shock promoter aneuploidy-induced stress response evaluating dna signal counting dna signal cell division mutant
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