
DOI . ORG {
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By controlling how damaged cells modify their surrounding tissue environment, a tumor suppressor gene can restrain, and an oncogene can promote, the development of cancer.
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Doi.org utilizes WORDPRESS.
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๐ Impressive Traffic: 500k - 1M visitors per month
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Keywords {๐}
cells, sasp, figure, senescence, view, article, cell, google, scholar, factors, ras, epithelial, induced, sen, cancer, human, fibroblasts, senescent, pre, baseline, xra, sasps, growth, tumor, antibody, secreted, senesce, data, oncogenic, proteins, levels, rep, signals, significantly, arrays, normal, secretory, analyzed, dna, damage, amplified, response, tissue, analysis, prostate, protein, array, suppressor, higher, text,
Topics {โ๏ธ}
tumor biology plos biol 6 legacy health system cookies plos open-access article distributed age-related diseases cell-nonautonomous tumor-suppressive function health ink4a/arf gene locus enzyme-linked immunosorbent assay interleukin-dependent inflammatory network original author d'adda di fagagna biotin-conjugated antibody cocktail degenerative diseases cell-autonomous tumor suppressor cell-nonautonomous tumor suppressor enzyme-linked immunosorbent assays candidate anti-cancer barrier human breast cancerโobservations promote cancer cell-nonautonomously fluorescence image analysis cell-nonautonomous promalignant activities tumor-suppressive senescence arrest higher-order nuclear organization wild-type p53 background cell surface ฮฒ-catenin serum-free incubation needed promote malignancy cell-nonautonomously p53 suppresses cancer beneficial cell-nonautonomous function oncogene-induced senescence relayed wild-type p53 pathway p53-deficient epithelial cells deleterious cell-nonautonomous effects cancer research uk generated conditioned media p53-deficient cancer cells proliferating p53-deficient cells gene expression program epithelial cell lines cells made p53-deficient dna-damaging chemotherapy senesce senescent vascular endothelium gro-ฮฑ/kc [orange] acquire therapy-induced mutations entrez gene ids shed surface molecules promotes multiple stages chemotherapy-induced sasps occur
Questions {โ}
- How does oncogenic RAS induce a SASP?
- How might senescent cells be deleterious?
- Why, then, are senescent cells found with increasing frequency during aging and at sites of age-related pathology?
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Libraries {๐}
- Foundation
- jQuery
- Leaflet
- Lightbox
- Modernizr
- Moment.js
- Underscore.js
- Video.js
- Vue.js
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- mx.zoho.eu
- mx2.zoho.eu
- mx3.zoho.eu
Name Servers:
- josh.ns.cloudflare.com
- zita.ns.cloudflare.com
CDN Services {๐ฆ}
- Cloudflare
- Crossref