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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Questions
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002234, but it redirected us to https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002234. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Author Summary The transcriptional responses of human hosts towards influenza viral pathogens are important for understanding virus-mediated immunopathology. Despite great advances gained through studies using model organisms, the complete temporal host transcriptional responses in a natural human system are poorly understood. In a human challenge study using live influenza (H3N2/Wisconsin) viruses, we conducted a clinically uninformed (unsupervised) factor analysis on gene expression profiles and established an ab initio molecular signature that strongly correlates to symptomatic clinical disease. This is followed by the identification of 42 biomarkers whose expression patterns best differentiate early from late phases of infection. In parallel, a clinically informed (supervised) analysis revealed over-stimulation of multiple viral sensing pathways in symptomatic hosts and linked their temporal trajectory with development of diverse clinical signs and symptoms. The resultant inflammatory cytokine profiles were shown to contribute to the pathogenesis because their significant increase preceded disease manifestation by 36 hours. In subclinical asymptomatic hosts, we discovered strong transcriptional regulation of genes involved in inflammasome activation, genes encoding virus interacting proteins, and evidence of active anti-oxidant and cell-mediated innate immune response. Taken together, our findings offer insights into influenza virus-induced pathogenesis and provide a valuable tool for disease monitoring and management in natural environments.

Matching Content Categories {📚}

  • Science
  • Education
  • Photography

Content Management System {📝}

What CMS is doi.org built with?


Doi.org operates using WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 76,079,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org has a revenue plan, but it's either invisible or we haven't found it.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

It is strange but we were not able to detect any theme on the page.

What WordPress plugins does this website use?

It is strange but we were not able to detect any plugins on the page.

Keywords {🔍}

expression, genes, figure, view, article, asx, cluster, google, scholar, subjects, gene, viral, time, temporal, influenza, disease, host, infection, response, hosts, symptomatic, responses, analysis, hpi, socs, immune, factor, significant, symptom, activation, clusters, signaling, asymptomatic, clinical, study, inoculation, httpsdoiorgjournalpgens, pdf, table, som, phenotype, blood, signature, profiles, inflammatory, virus, pathway, dynamics, human, antiviral,

Topics {✒️}

plos genet 7 plos pathog 5 cookies plos complex genetics open-access article distributed contributed reagents/materials/analysis tools global view pyran polymer-conjugated sod infectious diseases society pro-inflammatory cytokines macrophage-specific adhesion molecule global test adenovirus-mediated gene transfer interferon-dependent immune responses host anti-oxidant response symptomatic-specific temporal downregulation biweight robust m-estimator janus kinase-signal transducer anti-oxidant/stress genes sod1 random-effects term accounting lab-confirmed influenza infections aspirin-induced lipoxins depend cytoplasmic nod/nacht-lrr virus-mediated disease dynamics melanoma growth-suppressive properties anti-oxidant/stress response virus-induced tissue damage jak-stat signaling transduction original author influenza virus-induced pathogenesis yh mtm aoh understanding virus-mediated immunopathology serine/threonine kinase 25 cardiovascular diseases statistical risk-stratification model nod2 gene-deficiency resulted pathogen-elicited host responses gene expression profile immune response events repressing il-4-induced signals virus-induced oxidative stress interferon-stimulated antiviral genes ribosomal protein synthesis ifn-inducible rna helicase host immune response constant low-level expression presented evidence supporting nlr-mediated inflammasome activation cytokines

Questions {❓}

  • This leads to an interesting question ― what are the principal factors associated with such divergent disease outcome?

External Links {🔗}(292)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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