DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Payment Methods
Questions
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://journals.biologists.com/jcs/article-abstract/114/1/111/26537/Release-of-an-invasion-promoter-E-cadherin?redirectedFrom=fulltext, but it redirected us to https://journals.biologists.com/jcs/article-abstract/114/1/111/26537/Release-of-an-invasion-promoter-E-cadherin?redirectedFrom=fulltext. The analysis below is for the second page.

Title[redir]:
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1 | Journal of Cell Science | The Company of Biologists
Description:
ABSTRACT. The function of many transmembrane molecules can be altered by cleavage and subsequent release of their ectodomains. We have investigated ectodomain cleavage of the cell-cell adhesion and signal-transducing molecule E- cadherin. The E-cadherin ectodomain is constitutively shed from the surface of MCF-7 and MDCKts.srcC12 cells in culture. Release of the 80 kDa soluble E-cadherin fragment is stimulated by phorbol-12-myristate-13-acetate and is inhibited by overexpression of the tissue inhibitor of metalloproteinases-2. The metalloproteinases matrilysin and stromelysin-1 both cleave E-cadherin at the cell surface and release sE-CAD into the medium. The soluble E- cadherin fragment thus released inhibits E-cadherin functions in a paracrine way, as indicated by induction of invasion into collagen type I and inhibition of E-cadherin- dependent cell aggregation. Our results, therefore, suggest a novel mechanism by which metalloproteinases can influence invasion.

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌟 Strong Traffic: 100k - 200k visitors per month

Based on our best estimate, this website will receive around 100,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

open, cell, menu, journal, article, biology, search, sign, ecadherin, company, register, issue, release, invasion, alert, content, contacts, fragment, icon, ectodomain, metalloproteinases, biologists, jcs, decision, manuscript, imaging, mitochondrial, policy, registered, skip, input, suggest, journals, science, articles, matrilysin, stromelysin, author, information, versions, share, tools, cleavage, cadherin, surface, soluble, access, account, email, password,

Topics {✒️}

open menu e-cadherin/catenin complex cell science journal article research article fast-tracked decision making jcs fast-track option cleave e-cadherin e-cadherin ectodomain cell-cell adhesion journals journal search purchase veerle noë phorbol-12-myristate-13-acetate google scholar crossref cambridge cb24 9lf �cell biology cell biology guest editors ana marc mareel author release se-cad prokaryotic intracytoplasmic membranes article information company limited investigated ectodomain cleavage skip suggest view access $30 institution sign permissions sign rights reserved company special issue manuscripts cell sci content register cell surface ectodomain shedding decision letters initial decision account colleagues provide jcs editors manuscript resolution influence invasion barbara fingleton kathleen jacobs stefan vermeulen wim steelant

Payment Methods {📊}

Stripe

Questions {❓}

Don't already have an account?
Have a paper that has been reviewed elsewhere?

Schema {🗺️}

ScholarlyArticle:
      context:https://schema.org
      id:https://journals.biologists.com/jcs/article/114/1/111/26537/Release-of-an-invasion-promoter-E-cadherin
      name:Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1
      datePublished:2001-01-01
      hasPart:
            type:WebPageElement
            isAccessibleForFree:
            cssSelector:.paywall
      isPartOf:
         id:https://journals.biologists.com/jcs/issue/114/1
         type:PublicationIssue
         issueNumber:1
         datePublished:2001-01-01
         isPartOf:
            id:https://journals.biologists.com/jcs
            type:Periodical
            name:Journal of Cell Science
            issn:
               1477-9137
      url:https://dx.doi.org/10.1242/jcs.114.1.111
      keywords:
         E-cadherin/catenin complex
         Ectodomain shedding
         Matrix metalloproteinase
         Proteolysis
         Invasion
      inLanguage:en
      copyrightHolder:
      copyrightYear:2025
      publisher:
      author:
            name:Noë, Veerle
            affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
            type:Person
            name:Fingleton, Barbara
            affiliation:2 Vanderbilt University Medical Center, Department of Cell Biology, Nashville, Tennessee, USA
            type:Person
            name:Jacobs, Kathleen
            affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
            type:Person
            name:Crawford, Howard C.
            affiliation:2 Vanderbilt University Medical Center, Department of Cell Biology, Nashville, Tennessee, USA
            type:Person
            name:Vermeulen, Stefan
            affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
            type:Person
            name:Steelant, Wim
            affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
            type:Person
            name:Bruyneel, Erik
            affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
            type:Person
            name:Matrisian, Lynn M.
            affiliation:2 Vanderbilt University Medical Center, Department of Cell Biology, Nashville, Tennessee, USA
            type:Person
            name:Mareel, Marc
            affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
            type:Person
      description:ABSTRACT. The function of many transmembrane molecules can be altered by cleavage and subsequent release of their ectodomains. We have investigated ectodomain cleavage of the cell-cell adhesion and signal-transducing molecule E- cadherin. The E-cadherin ectodomain is constitutively shed from the surface of MCF-7 and MDCKts.srcC12 cells in culture. Release of the 80 kDa soluble E-cadherin fragment is stimulated by phorbol-12-myristate-13-acetate and is inhibited by overexpression of the tissue inhibitor of metalloproteinases-2. The metalloproteinases matrilysin and stromelysin-1 both cleave E-cadherin at the cell surface and release sE-CAD into the medium. The soluble E- cadherin fragment thus released inhibits E-cadherin functions in a paracrine way, as indicated by induction of invasion into collagen type I and inhibition of E-cadherin- dependent cell aggregation. Our results, therefore, suggest a novel mechanism by which metalloproteinases can influence invasion.
      pageStart:111
      pageEnd:118
      siteName:The Company of Biologists
      thumbnailURL:https://cob.silverchair-cdn.com/cob/content_public/journal/jcs/issue/114/1/5/m_joces_114_1.cover.png?Expires=1814821441&Signature=ExlbhwfufFpA6rOWOWYqaQVf4SYFpPnZDhtiwDz8EBeT1x6QjSVUH1ic44e9glGQHVcgnaDnHFHelKAxtDn7ByXldxxcMSswGy0WyYWI7ll4dfmh6EKQ1eY2z61woyaGwHT54CQ38S5O1Cppjg68vGAZEh5Z7KUjO~qH2slmuRc8cuUREjHyypOC3vx7jEHDopAfNA800yaUZN8LbYlYygXyuor-rfiMpLLl3qRBcDc98NdducGFLsZ81faTQxcCCDI13Khp5BvG-LuEjmRE1a0w1gC~coHZ6ja~2a8uBAJ~zrB8w-tusCkX7timZTkzAKUQ0HeTQ7HeuuL~y3bRJg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      headline:Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1
      image:https://cob.silverchair-cdn.com/cob/content_public/journal/jcs/issue/114/1/5/m_joces_114_1.cover.png?Expires=1814821441&Signature=ExlbhwfufFpA6rOWOWYqaQVf4SYFpPnZDhtiwDz8EBeT1x6QjSVUH1ic44e9glGQHVcgnaDnHFHelKAxtDn7ByXldxxcMSswGy0WyYWI7ll4dfmh6EKQ1eY2z61woyaGwHT54CQ38S5O1Cppjg68vGAZEh5Z7KUjO~qH2slmuRc8cuUREjHyypOC3vx7jEHDopAfNA800yaUZN8LbYlYygXyuor-rfiMpLLl3qRBcDc98NdducGFLsZ81faTQxcCCDI13Khp5BvG-LuEjmRE1a0w1gC~coHZ6ja~2a8uBAJ~zrB8w-tusCkX7timZTkzAKUQ0HeTQ7HeuuL~y3bRJg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      image:alt:Issue Cover
      isAccessibleForFree:
WebPageElement:
      isAccessibleForFree:
      cssSelector:.paywall
PublicationIssue:
      id:https://journals.biologists.com/jcs/issue/114/1
      issueNumber:1
      datePublished:2001-01-01
      isPartOf:
         id:https://journals.biologists.com/jcs
         type:Periodical
         name:Journal of Cell Science
         issn:
            1477-9137
Periodical:
      id:https://journals.biologists.com/jcs
      name:Journal of Cell Science
      issn:
         1477-9137
Person:
      name:Noë, Veerle
      affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
      name:Fingleton, Barbara
      affiliation:2 Vanderbilt University Medical Center, Department of Cell Biology, Nashville, Tennessee, USA
      name:Jacobs, Kathleen
      affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
      name:Crawford, Howard C.
      affiliation:2 Vanderbilt University Medical Center, Department of Cell Biology, Nashville, Tennessee, USA
      name:Vermeulen, Stefan
      affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
      name:Steelant, Wim
      affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
      name:Bruyneel, Erik
      affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
      name:Matrisian, Lynn M.
      affiliation:2 Vanderbilt University Medical Center, Department of Cell Biology, Nashville, Tennessee, USA
      name:Mareel, Marc
      affiliation:1 Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine , Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium

Social Networks {👍}(7)

External Links {🔗}(129)

Analytics and Tracking {📊}

Google Analytics
Google Analytics 4
Google Tag Manager
Google Universal Analytics

Libraries {📚}

jQuery
Sharethis
Video.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Com/cob/content_public/journal/jcs/issue/114/1/5/m_joces_114_1
Com/data/SiteBuilderAssets/Live/CSS/jcs/v-638761620424299800/site
Com/data/SiteBuilderAssets/Live/Images/jcs/apple-touch-icon1853126287
Com/data/SiteBuilderAssets/Live/Images/jcs/favicon-16x16-203215716
Com/data/SiteBuilderAssets/Live/Images/jcs/favicon-32x32-1588085212
Com/data/SiteBuilderAssets/Live/Images/jcs/favicon-1720491505
Com/data/SiteBuilderAssets/Live/Images/jcs/JCS_footer-1181661556
Com/data/SiteBuilderAssets/Live/Images/jcs/JCS_title_cropped1117566901
Com/data/SiteBuilderAssets/Live/Images/jcs/safari-pinned-tab975650023
Com/ImageLibrary/CoB_100_white-logo-lock-up_AW_RGB_FC_small3
Com/ImageLibrary/Development/Snippets/JCS-SI-Cell-Biology-of-Mitochondria-600x230SnippetBanner
Com/ImageLibrary/JCellScience/Snippets/0625-JCS-Snippet-mitrochondrialinnermembranecomposition
Com/ImageLibrary/JCellScience/Snippets/JCS-2026-Meeting-600x230-Snippet
Com/ImageLibrary/JCellScience/Snippets/JCS_FastTrack_Snippet_600x230_02
Com/ImageLibrary/JournalsGateway/Bluesky-icon
Com/ImageLibrary/JournalsGateway/Bluesky-icon-bw
Com/ImageLibrary/JournalsGateway/facebook-icon
Com/ImageLibrary/JournalsGateway/instagram-icon
Com/ImageLibrary/JournalsGateway/rss-icon
Com/ImageLibrary/JournalsGateway/x-icon
Com/ImageLibrary/JournalsGateway/youtube-icon
Com/ImageLibrary/Mastodon_Social_Icon_Circle_BW_TransparencyNoBlk
Com/ImageLibrary/wechat-white-transparent-noring
Com/Themes/Client/app/css/v-638848468170862866/bg_img
Com/Themes/Client/app/css/v-638870643329214546/site
Com/Themes/Client/app/jsdist/v-638870643450811692/site
Com/Themes/Silver/app/icons/v-638848469864512582/style
Com/Themes/Silver/app/js/jquery
Com/Themes/Silver/app/vendor/v-638848469881376018/jquery-migrate-3
Com/UI/app/svg/umbrella/logo
Cookiepro
Jsdelivr

4.91s.