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We began analyzing https://journals.biologists.com/jcs/article/122/4/481/30895/Induced-early-expression-of-mrf4-but-not-myog, but it redirected us to https://journals.biologists.com/jcs/article/122/4/481/30895/Induced-early-expression-of-mrf4-but-not-myog. The analysis below is for the second page.

Title[redir]:
Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo | Journal of Cell Science | The Company of Biologists
Description:
Muscle regulatory factors activate myogenesis in all vertebrates, but their role has been studied in great detail only in the mouse embryo, where all but myogenin – Myod, Myf5 and Mrf4 – are sufficient to activate (albeit not completely) skeletal myogenesis. In the zebrafish embryo, myod and myf5 are required for induction of myogenesis because their simultaneous ablation prevents muscle development. Here we show that mrf4 but not myog can fully rescue myogenesis in the myod/myf5 double morphant via a selective and robust activation of myod, in keeping with its chromatin-remodelling function in vitro. Rescue does not happen spontaneously, because the gene, unlike that in the mouse embryo, is expressed only at the onset of muscle differentiation, Moreover, because of the transient nature of morpholino inhibition, we were able to investigate how myogenesis occurs in the absence of a myotome. We report that in the complete absence of a myotome, subsequent myogenesis is abolished, whereas myogenesis does proceed, albeit abnormally, when the morpholino inhibition was not complete. Therefore our data also show that the early myotome is essential for subsequent skeletal muscle differentiation and patterning in the zebrafish.

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Keywords {🔍}

myod, mrf, muscle, embryos, myf, expression, zebrafish, myog, double, morphants, fig, gene, skeletal, development, mrna, myogenesis, myosin, expressed, mouse, myfmyod, morpholino, control, myotome, rescued, early, myogenin, differentiation, rescue, cell, genes, results, activation, view, cells, myogenic, normal, morpholinos, open, embryo, absence, injected, hpf, situ, somite, sections, dev, single, largedownload, slide, dpf,

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fitc-conjugated donkey anti-rabbit human β-thalassemia-specific morpholino open menu α-actin-gfp transgenic embryos α-actin-gfp transgenic zebrafish article information quantitative real-time pcr real-time quantitative pcr real-time rt-pcr 12-m-thin transverse sections company limited b-hlh transcription factors cell science journal fast-tracked decision making myogenic regulatory factors s1 manuscripts supplementary material fig induce muscle-specific rnas view largedownload slide jcs fast-track option promote fast-muscle differentiation muscle regulatory factors myf5/myod double-morphant embryos gene tools pbx homeodomain proteins rabbit anti-myf5 c-20 grants real-time pcr limited strictly flat-mount views myogenic inducing factors direct activity myod double-mutant mice total volume muscle regulatory gene recently published results positive-feedback loop myf5/mrf4 double mutant myod/myf5 double morphant coinjecting myf5/myod morpholinos myf5/myod double morphants 18s ribosomal rna official symbol myod1 lateral view anterior biologists mrf4-injected double morphants pcr probe templates real-time pcrs lineage specification factors

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ScholarlyArticle:
      context:https://schema.org
      id:https://journals.biologists.com/jcs/article/122/4/481/30895/Induced-early-expression-of-mrf4-but-not-myog
      name:Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo
      datePublished:2009-02-15
      isPartOf:
         id:https://journals.biologists.com/jcs/issue/122/4
         type:PublicationIssue
         issueNumber:4
         datePublished:2009-02-15
         isPartOf:
            id:https://journals.biologists.com/jcs
            type:Periodical
            name:Journal of Cell Science
            issn:
               1477-9137
      url:https://dx.doi.org/10.1242/jcs.038356
      keywords:
         Skeletal myogenesis
         MRF
         Zebrafish
         myf5
         Myod
         mrf4
         Myogenin
         Myotome
      inLanguage:en
      copyrightHolder:
      copyrightYear:2025
      publisher:
      author:
            name:Schnapp, Esther
            affiliation:1 Stem Cell Research Institute, DiBiT, San Raffaele Scientific Institute, 58 via Olgettina, 20132 Milan, Italy
            type:Person
            name:Pistocchi, Anna Silvia
            affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
            type:Person
            name:Karampetsou, Evangelia
            affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
            type:Person
            name:Foglia, Efrem
            affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
            type:Person
            name:Lamia, Carla Lora
            affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
            type:Person
            name:Cotelli, Franco
            affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
            type:Person
            name:Cossu, Giulio
            affiliation:1 Stem Cell Research Institute, DiBiT, San Raffaele Scientific Institute, 58 via Olgettina, 20132 Milan, Italy 2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
            type:Person
      description:Muscle regulatory factors activate myogenesis in all vertebrates, but their role has been studied in great detail only in the mouse embryo, where all but myogenin – Myod, Myf5 and Mrf4 – are sufficient to activate (albeit not completely) skeletal myogenesis. In the zebrafish embryo, myod and myf5 are required for induction of myogenesis because their simultaneous ablation prevents muscle development. Here we show that mrf4 but not myog can fully rescue myogenesis in the myod/myf5 double morphant via a selective and robust activation of myod, in keeping with its chromatin-remodelling function in vitro. Rescue does not happen spontaneously, because the gene, unlike that in the mouse embryo, is expressed only at the onset of muscle differentiation, Moreover, because of the transient nature of morpholino inhibition, we were able to investigate how myogenesis occurs in the absence of a myotome. We report that in the complete absence of a myotome, subsequent myogenesis is abolished, whereas myogenesis does proceed, albeit abnormally, when the morpholino inhibition was not complete. Therefore our data also show that the early myotome is essential for subsequent skeletal muscle differentiation and patterning in the zebrafish.
      pageStart:481
      pageEnd:488
      siteName:The Company of Biologists
      thumbnailURL:https://cob.silverchair-cdn.com/cob/content_public/journal/jcs/issue/122/4/3/m_joces_122_4_cover.png?Expires=1814624734&Signature=D3XkZCBce42HKyeSyTMkw4PbD86uP~6kziZ6zqta~HC6L5dIa0cUzl80sDldIjKvqmSbu6HI0YUA2Z0150F2YAmz43-bCGJVbYSe42Ig-HblueeTf7-u48p0M4geqlBqbKt0rzE~jXIfvdclrC99~HxI2KXZ~OFlk1EibkUDgLPk1m-nDTZQr2szT3NJPsTcDWnPQmutQ7a9ZbJG6DGGdiy6yY7czj8jyZjTExUqpuC~P8MCBFWULxypjdCFM8xMzN64f3x5~nXyGBz0Fro86-ttefpMy0q38KJp1wJ2tfzP-PkaB3bBKV11qur6CsitdIzICujqZbTICKrshafkdA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      headline:Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo
      image:https://cob.silverchair-cdn.com/cob/content_public/journal/jcs/issue/122/4/3/m_joces_122_4_cover.png?Expires=1814624734&Signature=D3XkZCBce42HKyeSyTMkw4PbD86uP~6kziZ6zqta~HC6L5dIa0cUzl80sDldIjKvqmSbu6HI0YUA2Z0150F2YAmz43-bCGJVbYSe42Ig-HblueeTf7-u48p0M4geqlBqbKt0rzE~jXIfvdclrC99~HxI2KXZ~OFlk1EibkUDgLPk1m-nDTZQr2szT3NJPsTcDWnPQmutQ7a9ZbJG6DGGdiy6yY7czj8jyZjTExUqpuC~P8MCBFWULxypjdCFM8xMzN64f3x5~nXyGBz0Fro86-ttefpMy0q38KJp1wJ2tfzP-PkaB3bBKV11qur6CsitdIzICujqZbTICKrshafkdA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      image:alt:Issue Cover
PublicationIssue:
      id:https://journals.biologists.com/jcs/issue/122/4
      issueNumber:4
      datePublished:2009-02-15
      isPartOf:
         id:https://journals.biologists.com/jcs
         type:Periodical
         name:Journal of Cell Science
         issn:
            1477-9137
Periodical:
      id:https://journals.biologists.com/jcs
      name:Journal of Cell Science
      issn:
         1477-9137
Person:
      name:Schnapp, Esther
      affiliation:1 Stem Cell Research Institute, DiBiT, San Raffaele Scientific Institute, 58 via Olgettina, 20132 Milan, Italy
      name:Pistocchi, Anna Silvia
      affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
      name:Karampetsou, Evangelia
      affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
      name:Foglia, Efrem
      affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
      name:Lamia, Carla Lora
      affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
      name:Cotelli, Franco
      affiliation:2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy
      name:Cossu, Giulio
      affiliation:1 Stem Cell Research Institute, DiBiT, San Raffaele Scientific Institute, 58 via Olgettina, 20132 Milan, Italy 2 Department of Biology, University of Milan, 26 via Celoria, 20133 Milan, Italy

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