DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Payment Methods
Questions
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://journals.biologists.com/dev/article-abstract/125/7/1337/40195/The-let-99-gene-is-required-for-proper-spindle?redirectedFrom=fulltext, but it redirected us to https://journals.biologists.com/dev/article-abstract/125/7/1337/40195/The-let-99-gene-is-required-for-proper-spindle?redirectedFrom=fulltext. The analysis below is for the second page.

Title[redir]:
The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo | Development | The Company of Biologists
Description:
ABSTRACT. The orientation of cell division is a critical aspect of development. In 2-cell C. elegans embryos, the spindle in the posterior cell is aligned along the long axis of the embryo and contributes to the unequal partitioning of cytoplasm, while the spindle in the anterior cell is oriented transverse to the long axis. Differing spindle alignments arise from blastomere-specific rotations of the nuclear-centrosome complex at prophase. We have found that mutations in the maternally expressed gene let-99 affect spindle orientation in all cells during the first three cleavages. During these divisions, the nuclear-centrosome complex appears unstable in position. In addition, in almost half of the mutant embryos, there are reversals of the normal pattern of spindle orientations at second cleavage: the spindle of the anterior cell is aligned with the long axis of the embryo and nuclear rotation fails in the posterior cell causing the spindle to form transverse to the long axis. In most of the remaining embryos, spindles in both cells are transverse at second cleavage. The distributions of several asymmetrically localized proteins, including P granules and PAR-3, are normal in early let-99 embryos, but are perturbed by the abnormal cell division orientations at second cleavage. The accumulation of actin and actin capping protein, which marks the site involved in nuclear rotation in 2-cell wild-type embryos, is abnormal but is not reversed in let-99 mutant embryos. Based on these data, we conclude that let-99(+) is required for the proper orientation of spindles after the establishment of polarity, and we postulate that let-99(+) plays a role in interactions between the astral microtubules and the cortical cytoskeleton.

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌟 Strong Traffic: 100k - 200k visitors per month

Based on our best estimate, this website will receive around 100,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

cell, open, development, spindle, menu, journal, article, biology, search, sign, embryos, orientation, cleavage, company, long, axis, alert, subject, content, register, contacts, elegans, embryo, icon, division, transverse, nuclear, rotation, biologists, access, latest, developmental, fellows, mechanism, browse, policy, registered, skip, input, suggest, journals, articles, april, research, gene, required, proper, author, versions, share,

Topics {✒️}

open menu article information development cell science journal 2-cell wild-type embryos node latest developmental biology nuclear-centrosome complex stem cell research biologists journal search blastomere-specific rotations asymmetrically localized proteins google scholar crossref webinar series showcasing colleagues survey researchers cambridge cb24 9lf visit development presents nuclear rotation fails talented fellows chosen posterior cell causing ken kemphues author maternally expressed gene actin capping protein curated subject collections company limited skip developmental biology suggest proper spindle orientation latest papers institution sign permissions sign rights reserved company nuclear rotation view access $30 cell division posterior cell content spindle orientations cardiovascular development development editors proper orientation asymmetric division anterior cell account spindle orientation elegans embryos mutant embryos remaining embryos

Payment Methods {📊}

Stripe

Questions {❓}

Don't already have an account?

Schema {🗺️}

ScholarlyArticle:
      context:https://schema.org
      id:https://journals.biologists.com/dev/article/125/7/1337/40195/The-let-99-gene-is-required-for-proper-spindle
      name:The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
      datePublished:1998-04-01
      hasPart:
            type:WebPageElement
            isAccessibleForFree:
            cssSelector:.paywall
      isPartOf:
         id:https://journals.biologists.com/dev/issue/125/7
         type:PublicationIssue
         issueNumber:7
         datePublished:1998-04-01
         isPartOf:
            id:https://journals.biologists.com/dev
            type:Periodical
            name:Development
            issn:
               1477-9129
      url:https://dx.doi.org/10.1242/dev.125.7.1337
      keywords:
         Spindle orientation
         Nuclear rotation
         Asymmetric division
         Caenorhabditis elegans
         let-99
         Cleavage
      inLanguage:en
      copyrightHolder:
      copyrightYear:2025
      publisher:
      author:
            name:Rose, Lesilee S.
            affiliation:1 Section of Genetics and Development , Cornell University , Ithaca, NY 14853, University of California, Davis, CA 95616, USA 2 Section of Molecular and Cellular Biology , University of California , Davis, CA 95616, USA
            type:Person
            name:Kemphues, Ken
            affiliation:1 Section of Genetics and Development , Cornell University , Ithaca, NY 14853, University of California, Davis, CA 95616, USA
            type:Person
      description:ABSTRACT. The orientation of cell division is a critical aspect of development. In 2-cell C. elegans embryos, the spindle in the posterior cell is aligned along the long axis of the embryo and contributes to the unequal partitioning of cytoplasm, while the spindle in the anterior cell is oriented transverse to the long axis. Differing spindle alignments arise from blastomere-specific rotations of the nuclear-centrosome complex at prophase. We have found that mutations in the maternally expressed gene let-99 affect spindle orientation in all cells during the first three cleavages. During these divisions, the nuclear-centrosome complex appears unstable in position. In addition, in almost half of the mutant embryos, there are reversals of the normal pattern of spindle orientations at second cleavage: the spindle of the anterior cell is aligned with the long axis of the embryo and nuclear rotation fails in the posterior cell causing the spindle to form transverse to the long axis. In most of the remaining embryos, spindles in both cells are transverse at second cleavage. The distributions of several asymmetrically localized proteins, including P granules and PAR-3, are normal in early let-99 embryos, but are perturbed by the abnormal cell division orientations at second cleavage. The accumulation of actin and actin capping protein, which marks the site involved in nuclear rotation in 2-cell wild-type embryos, is abnormal but is not reversed in let-99 mutant embryos. Based on these data, we conclude that let-99(+) is required for the proper orientation of spindles after the establishment of polarity, and we postulate that let-99(+) plays a role in interactions between the astral microtubules and the cortical cytoskeleton.
      pageStart:1337
      pageEnd:1346
      siteName:The Company of Biologists
      thumbnailURL:https://cob.silverchair-cdn.com/cob/content_public/journal/dev/issue/125/7/2/m_dev_125_7_1998_cover.png?Expires=1814823205&Signature=R3~xHLFItJsMIGEXfiu3BdSmiJQRw0SvSvLjVa~rJ1EWYxgG2Z98M4eCOyT-DDIkSSMUsj0xT-VZ~ozfBwkkAsqV4wH2YxZVTTepq9Spaf2bgdIgn4rpf1atoJGnkkLTT8stHZt1VX8WhnGLOtUyGvK6QK8mO0m9Bgb-zqxTCRF~tCLqlX1cTdcG-HICPe~C1pp3W96A~9wfEFSm~ecVMehCdcFleqNQYDGN1dH9pgaLktF8~SN1gaaKhi6lzLPtlCgMO3U5WccpFMojsyGehhJgwrX9JXOzvmGB1ka-c3uZ72O~wkXBZTvK~uo52PNcd~uCCdX6vucOaeCHtujdfA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      headline:The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
      image:https://cob.silverchair-cdn.com/cob/content_public/journal/dev/issue/125/7/2/m_dev_125_7_1998_cover.png?Expires=1814823205&Signature=R3~xHLFItJsMIGEXfiu3BdSmiJQRw0SvSvLjVa~rJ1EWYxgG2Z98M4eCOyT-DDIkSSMUsj0xT-VZ~ozfBwkkAsqV4wH2YxZVTTepq9Spaf2bgdIgn4rpf1atoJGnkkLTT8stHZt1VX8WhnGLOtUyGvK6QK8mO0m9Bgb-zqxTCRF~tCLqlX1cTdcG-HICPe~C1pp3W96A~9wfEFSm~ecVMehCdcFleqNQYDGN1dH9pgaLktF8~SN1gaaKhi6lzLPtlCgMO3U5WccpFMojsyGehhJgwrX9JXOzvmGB1ka-c3uZ72O~wkXBZTvK~uo52PNcd~uCCdX6vucOaeCHtujdfA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      image:alt:Issue Cover
      isAccessibleForFree:
WebPageElement:
      isAccessibleForFree:
      cssSelector:.paywall
PublicationIssue:
      id:https://journals.biologists.com/dev/issue/125/7
      issueNumber:7
      datePublished:1998-04-01
      isPartOf:
         id:https://journals.biologists.com/dev
         type:Periodical
         name:Development
         issn:
            1477-9129
Periodical:
      id:https://journals.biologists.com/dev
      name:Development
      issn:
         1477-9129
Person:
      name:Rose, Lesilee S.
      affiliation:1 Section of Genetics and Development , Cornell University , Ithaca, NY 14853, University of California, Davis, CA 95616, USA 2 Section of Molecular and Cellular Biology , University of California , Davis, CA 95616, USA
      name:Kemphues, Ken
      affiliation:1 Section of Genetics and Development , Cornell University , Ithaca, NY 14853, University of California, Davis, CA 95616, USA

Social Networks {👍}(7)

External Links {🔗}(103)

Analytics and Tracking {📊}

Google Analytics
Google Analytics 4
Google Tag Manager
Google Universal Analytics

Libraries {📚}

jQuery
Sharethis
Video.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Com/cob/content_public/journal/dev/issue/125/7/2/m_dev_125_7_1998_cover
Com/data/SiteBuilderAssets/Live/CSS/dev/v-638761629243146705/site
Com/data/SiteBuilderAssets/Live/Images/dev/apple-touch-icon808323293
Com/data/SiteBuilderAssets/Live/Images/dev/DEV_footer127823882
Com/data/SiteBuilderAssets/Live/Images/dev/DEV_title_cropped1750185022
Com/data/SiteBuilderAssets/Live/Images/dev/favicon-16x16-1159682937
Com/data/SiteBuilderAssets/Live/Images/dev/favicon-32x32-1428583863
Com/data/SiteBuilderAssets/Live/Images/dev/favicon662918389
Com/data/SiteBuilderAssets/Live/Images/dev/safari-pinned-tab1999309873
Com/ImageLibrary/CoB_100_white-logo-lock-up_AW_RGB_FC_small3
Com/ImageLibrary/Development/Snippets/0225_Development_mechanism
Com/ImageLibrary/Development/Snippets/0624_DevPres_general
Com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet
Com/ImageLibrary/Development/Snippets/pathway%20to%20independence%20image
Com/ImageLibrary/JournalsGateway/Bluesky-icon
Com/ImageLibrary/JournalsGateway/Bluesky-icon-bw
Com/ImageLibrary/JournalsGateway/facebook-icon
Com/ImageLibrary/JournalsGateway/instagram-icon
Com/ImageLibrary/JournalsGateway/rss-icon
Com/ImageLibrary/JournalsGateway/x-icon
Com/ImageLibrary/JournalsGateway/youtube-icon
Com/ImageLibrary/Mastodon_Social_Icon_Circle_BW_TransparencyNoBlk
Com/ImageLibrary/wechat-white-transparent-noring
Com/Themes/Client/app/css/v-638848468170862866/bg_img
Com/Themes/Client/app/css/v-638870643329214546/site
Com/Themes/Client/app/jsdist/v-638870643450811692/site
Com/Themes/Silver/app/icons/v-638848469864512582/style
Com/Themes/Silver/app/js/jquery
Com/Themes/Silver/app/vendor/v-638848469881376018/jquery-migrate-3
Com/UI/app/svg/umbrella/logo
Cookiepro
Jsdelivr

3.92s.