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We began analyzing https://journals.biologists.com/dev/article-abstract/125/10/1877/39797/The-Tlx-2-homeobox-gene-is-a-downstream-target-of?redirectedFrom=fulltext, but it redirected us to https://journals.biologists.com/dev/article-abstract/125/10/1877/39797/The-Tlx-2-homeobox-gene-is-a-downstream-target-of?redirectedFrom=fulltext. The analysis below is for the second page.

Title[redir]:
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development | Development | The Company of Biologists
Description:
ABSTRACT. TGFβ-related factors are critical regulators of vertebrate mesoderm development. However, the signalling cascades required for their function during this developmental process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in P19 cells, and this response is mediated by BMP type I receptors and Smad1. These results suggest that Tlx-2 is a downstream target gene for BMP signalling in the primitive streak where BMP-4 and other TGFβ-related factors are expressed. Furthermore, disruption of Tlx-2 function leads to early embryonic lethality. Similar to BMP4 and ALK3 mutants, the mutant embryos display severe defects in primitive streak and mesoderm formation. These experiments thus define a BMP/Tlx-2 signalling pathway that is required during early mammalian gastrulation.

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open, development, menu, article, bmp, journal, biology, search, sign, tlx, company, gene, signalling, mesoderm, developmental, alert, subject, content, suggest, register, contacts, homeobox, required, mouse, icon, factors, primitive, streak, embryos, pathway, biologists, access, latest, cell, fellows, mechanism, browse, policy, registered, skip, input, journals, articles, research, downstream, target, author, versions, share, tools,

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tgfβ-related factors open menu article research article article information development cell science journal node latest developmental biology bmp/tlx-2 signalling pathway 1998 previous article factors shape biologists journal visit development presents search early embryonic lethality bone morphogenetic protein google scholar crossref webinar series showcasing stem cell research colleagues survey researchers cambridge cb24 9lf tlx-2 homeobox gene vertebrate mesoderm development talented fellows chosen tlx-2 function leads early mammalian gastrulation curated subject collections company limited downstream target gene skip signalling cascades required homeobox gene expressed mouse mesoderm development results suggest developmental biology latest papers institution sign permissions sign rights reserved company homeobox gene view access $30 suggest bmp signalling cardiovascular development development editors content downstream target mouse embryos bmp-2 signals bmp type

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ScholarlyArticle:
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      id:https://journals.biologists.com/dev/article/125/10/1877/39797/The-Tlx-2-homeobox-gene-is-a-downstream-target-of
      name:The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
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      url:https://dx.doi.org/10.1242/dev.125.10.1877
      keywords:
         Mouse
         Gastrulation
         Mesoderm
         Homeobox gene
         Bone morphogenetic protein (BMP).
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      author:
            name:Tang, Shao Jun
            affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
            type:Person
            name:Hoodless, Pamela A.
            affiliation:2 Program in Developmental Biology, The Hospital for Sick Children , 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
            type:Person
            name:Lu, Zhan
            affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
            type:Person
            name:Breitman, Martin L.
            type:Person
            name:McInnes, Roderick R.
            affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 2 Program in Developmental Biology, The Hospital for Sick Children , 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
            type:Person
            name:Wrana, Jeffrey L.
            affiliation:2 Program in Developmental Biology, The Hospital for Sick Children , 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
            type:Person
            name:Buchwald, Manuel
            affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
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      description:ABSTRACT. TGFβ-related factors are critical regulators of vertebrate mesoderm development. However, the signalling cascades required for their function during this developmental process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in P19 cells, and this response is mediated by BMP type I receptors and Smad1. These results suggest that Tlx-2 is a downstream target gene for BMP signalling in the primitive streak where BMP-4 and other TGFβ-related factors are expressed. Furthermore, disruption of Tlx-2 function leads to early embryonic lethality. Similar to BMP4 and ALK3 mutants, the mutant embryos display severe defects in primitive streak and mesoderm formation. These experiments thus define a BMP/Tlx-2 signalling pathway that is required during early mammalian gastrulation.
      pageStart:1877
      pageEnd:1887
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      headline:The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
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PublicationIssue:
      id:https://journals.biologists.com/dev/issue/125/10
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Person:
      name:Tang, Shao Jun
      affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
      name:Hoodless, Pamela A.
      affiliation:2 Program in Developmental Biology, The Hospital for Sick Children , 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
      name:Lu, Zhan
      affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
      name:Breitman, Martin L.
      name:McInnes, Roderick R.
      affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 2 Program in Developmental Biology, The Hospital for Sick Children , 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
      name:Wrana, Jeffrey L.
      affiliation:2 Program in Developmental Biology, The Hospital for Sick Children , 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada
      name:Buchwald, Manuel
      affiliation:1 Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada 3 Department of Molecular and Medical Genetics , University of Toronto, Ontario, Canada

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