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We began analyzing https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-022-00863-0, but it redirected us to https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-022-00863-0. The analysis below is for the second page.

Title[redir]:
Bile pigments in emergency and critical care medicine | European Journal of Medical Research | Full Text
Description:
Bile pigments, such as bilirubin and biliverdin, are end products of the heme degradation pathway in mammals and are widely known for their cytotoxic effects. However, recent studies have revealed that they exert cytoprotective effects through antioxidative, anti-inflammatory, and immunosuppressive properties. All these mechanisms are indispensable in the treatment of diseases in the field of emergency and critical care medicine, such as coronary ischemia, stroke, encephalomyelitis, acute lung injury/acute respiratory distress syndrome, mesenteric ischemia, and sepsis. While further research is required before the safe application of bile pigments in the clinical setting, their underlying mechanisms shed light on their utilization as therapeutic agents in the field of emergency and critical care medicine. This article aims to summarize the current understanding of bile pigments and re-evaluate their therapeutic potential in the diseases listed above.

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Science
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Keywords {🔍}

pubmed, article, google, scholar, cas, bile, pigments, bilirubin, effects, cell, cells, ros, biliverdin, heme, administration, injury, central, medicine, lung, critical, diseases, therapeutic, oxidative, antioxidant, rats, care, treatment, encephalomyelitis, clinical, showed, inflammatory, emergency, pathway, antiinflammatory, levels, disease, studies, mechanisms, damage, apoptosis, cardiac, ischemia, demonstrated, role, reduced, fig, study, expression, transplantation, graft,

Topics {✒️}

bleomycin-induced lung damage uridine-diphosphoglucuronic glucuronosyltransferase conjugates additional information publisher' anti-4-hne antibody-positive cells xenobiotic-induced murine model pre-bv-treated specimens 24 lps-induced neutrophil infiltration weakens ho-1-mediated antioxidant reactive oxygen species stopped sepsis-induced ileus anti-inflammation therapy alter nf-κb activation oxidative stress-induced damage acute rejection reduction cardiac ischemia/reperfusion injury transcription factor nf-kappa bv-treated intestinal grafts critical care medicine improving long-term outcomes accentuated clp-induced increase diminished anti-inflammatory pathways scavenging phagocytosis-induced ros lps-induced endotoxemia [55] author information authors anti-donor alloantibodies 60 days privacy choices/manage cookies br-bv redox cycle tumor necrosis factor human myocardial ischemia bmc bilirubin/biliverdin therapeutic application 8-hydroxy-2′-deoxyguanosine ali/ards account european journal anti-inflammatory mediators ho-1 ischemia/reperfusion injury ischemia-reperfusion injury reduced neutrophil migration induced pulmonary fibrosis lung endothelial cells br-administered blm groups immune-mediated encephalomyelitis european economic area graft post-transplantation experimental autoimmune encephalomyelitis vascular endothelial injury biliverdin administration prevents bronchoalveolar lavage fluid proofreading sections 2047-783x contact monocyte chemoattractant protein

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What is nuclear factor kappa B (NF-kappaB) doing in and to the mitochondrion?

Schema {🗺️}

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