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We began analyzing https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-023-02161-0, but it redirected us to https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-023-02161-0. The analysis below is for the second page.

Title[redir]:
Treatments and whole exon sequencing of a case with multiple primary lung cancer | Journal of Cardiothoracic Surgery | Full Text
Description:
Introduction The number of patients with synchronous multiple primary lung cancer (sMPLC) has increased recently. However, diagnosing and selecting the appropriate therapeutic strategy for this type of disease is not simple. Case presentation This report presented a case of sMPLC with lymph node metastasis. With no smoking and cancer history, this patient had seven nodules in the right lung and underwent single-portal video-assisted thoracoscopic surgery (VATS). In addition, she received four cycles of chemotherapy after the operation. Whole exon sequencing (WES) was performed in five resected tissue samples (four tumors and one lymph node). We conducted genomic profiling and clone evolution analysis of the five samples. Gene detection helped to confirm that the metastasis lymph node was transferred from one nodule. There was apparent heterogeneity of gene mutations among the five samples of the patient, with only one shared “neurofilament heavy polypeptide” (NEFH) mutation. A dominant substitution of C > T/G > A was found in all the samples. Pyclone model was used to calculate all tissues

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Keywords {🔍}

lung, cancer, multiple, article, samples, smplc, treatment, fig, primary, lymph, mutations, case, nodules, surgery, patients, node, adenocarcinoma, detection, analysis, data, sequencing, patient, chemotherapy, genomic, nefh, lobe, google, scholar, pathological, surgical, results, thorac, information, exon, metastasis, lesions, bmc, type, nodule, mutation, found, pyclone, showed, cancers, diagnosis, resection, ggos, study, solid, surg,

Topics {✒️}

multifocal ground-glass opacities ground-glass opacity component actual nucleotide position/change carboplatin 500 mg + pemetrexed 800 mg additional information publisher' small-cell lung cancer tumor-specific causal inference national research committee bmc surg primary lung cancers springer nature multiple lung cancers driver gene arid1b beijing chao-yang hospital privacy choices/manage cookies gene detection helped single nucleotide variants pathological sections thoracic surgery small sample size state privacy rights cancer cell fraction bilateral lung lobes multiple pulmonary sites fundamental research funds authors scientific editing clonal population structure case presentation chest ct scan bmc writing—review & editing multiomics analysis reveals supplementary table cardiothoracic surgery home graduate innovation fund cancer/cancer hospital american joint committee solid predominant subtype creative commons licence staging international association poorly differentiated adenocarcinoma moderately differentiated adenocarcinoma treat multiple ggos discussion positive lymph node metastatic lymph node gene detection normal lung parenchyma comprehensive treatment mode capital medical university

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