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We began analyzing https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.612960, but it redirected us to https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.612960. The analysis below is for the second page.

Title[redir]:
Matrix Metalloproteinase-7 Affects Connexin-43 Levels, Electrical Conduction, and Survival After Myocardial Infarction | Circulation
Description:
Background— Matrix metalloproteinases (MMPs) contribute to left ventricular remodeling after myocardial infarction (MI). Specific causative roles of particular MMPs, however, remain unclear. MMP-7 is abundant in cardiomyocytes and macrophages, but MMP-7 function after MI has not been defined. Methods and Results— Wild-type (WT; n=55) and MMP-7–null (MMP-7−/−; n=32) mice underwent permanent coronary artery ligation for 7 days. MI sizes were similar, but survival was greatly improved in MMP-7−/− mice. The survival difference could not be attributed to differences in left ventricular dilation because end-diastolic volumes increased similarly. ECG analysis revealed a prolonged PR interval in WT but not in MMP-7−/− post-MI mice. Post-MI conduction velocity, determined by optically mapping electrical wavefront propagation, decreased to 78±6% of control for WT and was normalized in MMP-7−/− mice. In WT mice, slower conduction velocity correlated with a 53% reduction in the gap junction protein connexin-43. Direct binding of MMP-7 to connexin-43, determined by surface plasmon resonance technology, occurred in a dose-dependent manner. Connexin-43 processing by MMP-7 was confirmed by in silico and in vitro substrate analyses and MMP-7 infusion induced arrhythmias in vivo. Conclusions— MMP-7 deletion results in improved survival and myocardial conduction patterns after MI. This is the first report to implicate MMP-7 in post-MI remodeling and to demonstrate that connexin-43 is a novel MMP-7 substrate.

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mmp, connexin, mice, crossref, university, pubmed, department, control, google, scholar, postmi, levels, heart, remodeling, conduction, myocardial, medical, biology, center, fgs, division, charleston, electrical, remote, circulation, region, research, cleavage, figure, cell, survival, view, increased, ligand, medicine, health, matrix, gap, cardiology, san, antonio, article, infarction, mmps, binding, infusion, study, south, carolina, unoperated,

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supplemental material file aha/asa scientific statements increased matrix metalloproteinases matrix metalloproteinase-7-dependent release clinical perspective org/cgi/content/full/circulationaha american heart association discussion mmp-7 2 matrix metalloproteinases low-molecular-weight mmp expressed supplements download pdf myocyte cross-sectional areas results— wild-type surface plasmon resonance 1093/toxsci/kfad105 crossref micah potentiometric dye di-4-anepps submit plasticizer di-2-ethylhexyl phthalate cell-extracellular matrix interactions red ™ aha references background acknowledgments connexin-43 cleavage results normal myocyte-myocyte interface tumor necrosis factor-α5 tumor necrosis factor-alpha main content advertisement ischaemic heart disease heart failure stroke specific protein-protein interaction c-terminus cleavage site article recently published high-resolution optical maps terms 16 end-diastolic volume extracellular matrix remodeling concentration-dependent decreased levels representative high-magnification scans improved post-mi survival post-mi remodeling process expanded methods section post-mi mmp-7−/− lv acute myocardial ischemia mmp-7−/− post-mi hearts animal models international journal past animal studies half-maximum dose determined 7-day post-mi mmp-7−/−

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