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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.111.253377, but it redirected us to https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.111.253377. The analysis below is for the second page.

Title[redir]:
NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis | Circulation Research
Description:
Rationale:NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and within atherosclerotic lesions, yet its function in atherosclerosis is unknown. Objective:Nur77 regulates the development of monocytes, particularly patrolling Ly6C− monocytes that may be involved in resolution of inflammation. We sought to determine how absence of nuclear receptor subfamily 4, group A, member 1 (NR4A1) in hematopoietic cells affected atherosclerosis development. Methods and Results:Nur77−/− chimeric mice on a Ldlr−/− background showed a 3-fold increase in atherosclerosis development when fed a Western diet for 20 weeks, despite having a drastic reduction in Ly6C− patrolling monocytes. In a second model, mice deficient in both Nur77 and ApoE (ApoE−/−Nur77−/−) also showed increased atherosclerosis after 11 weeks of Western diet. Atherosclerosis was associated with a significant change in macrophage polarization toward a proinflammatory phenotype, with high expression of tumor necrosis factor-α and nitric oxide and low expression of Arginase-I. Moreover, we found increased expression of toll-like receptor 4 mRNA and protein in Nur77−/− macrophages as well as increased phosphorylation of the p65 subunit of NFκB. Inhibition of NFκB activity blocked excess activation of Nur77−/− macrophages. Conclusions:We conclude that the absence of Nur77 in monocytes and macrophages results in enhanced toll-like receptor signaling and polarization of macrophages toward a proinflammatory M1 phenotype. Despite having fewer monocytes, Nur77−/− mice developed significant atherosclerosis when fed a Western diet. These studies indicate that Nur77 is a novel target for modulating the inflammatory phenotype of monocytes and macrophages and may be important for regulation of atherogenesis.

Matching Content Categories {📚}

  • Education
  • Science
  • Politics

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌌 Gigantic Traffic: 2M - 5M visitors per month


Based on our best estimate, this website will receive around 4,735,289 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

mice, macrophages, monocytes, lyc, expression, crossref, pubmed, google, scholar, inflammatory, figure, inflammation, monocyte, cells, increased, macrophage, biology, atherosclerosis, receptor, diet, western, nra, bone, nuclear, apoenur, control, data, marrow, response, blood, cell, jolla, subset, london, expressed, weeks, activation, haverford, college, phenotype, nfκb, apoe, quantification, development, circulation, view, proinflammatory, receptors, red, lipid,

Topics {✒️}

aha/asa scientific statements c57bl/6j wild-type control dii–oxidized low-density lipoprotein american heart association c57bl/6j wild-type congenic c57bl/6j background bone marrow–derived macrophages cd11b+f4/80+ly6c− monocytes circulating inflammatory nur77−gfplowcd11b+ly6c+ monocytes steroid/thyroid receptor family sorted gfp-cd11b+ly6c+ cells heart failure stroke splenic cd115+cd11b+ cells submit macrophage-specific abca1 knock early genes regulated quantitative real-time pcr red ™ aha trend orphan nuclear receptor closed ligand-binding pocket early response genes bone marrow transplant atherosclerosis-susceptible ldlr−/− mice supplements download pdf neutral lipid content increased lipid accumulation ly6c− monocyte-derived macrophages neutrophil-dependent pulmonary immunity infiltrating blood-derived macrophages srai/ii surface expression ligand-independent nuclear receptors nur77-deficient mice showed nur77-deficient macrophages exhibited tumor necrosis factor-α bone marrow transplants main content advertisement reduce lipid loading nur77−/− bone marrow reduces macrophage accumulation increases atherosclerosis richard cd11b+f4/80+ peritoneal macrophages nur77-deficient mice fed nuclear receptor ngfi nuclear receptor 4a1 circulation research bone marrow compartment thioglycolate-elicited peritoneal macrophages anti-inflammatory m2 macrophages apoe−/−nur77−/− mice showed

Questions {❓}

  • Nr4a nuclear orphan receptors: protective in vascular disease?
  • What Is Known?
  • What New Information Does This Article Contribute?

Social Networks {👍}(10)

External Links {🔗}(342)

Analytics and Tracking {📊}

  • Google Analytics
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Libraries {📚}

  • Animate.css
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Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
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Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Cookielaw

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