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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://www.ahajournals.org/doi/10.1161/01.CIR.97.11.1071, but it redirected us to https://www.ahajournals.org/doi/10.1161/01.CIR.97.11.1071. The analysis below is for the second page.

Title[redir]:
Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal | Circulation
Description:
Background—Atherosclerotic lesion formation is a complex process, in part mediated by inflammatory and oxidative mechanisms including lipid peroxidation. To further characterize the potential role of lipid peroxidation products in atherogenesis, we studied the effects of 4-hydroxy-2-nonenal (HNE) on rat aortic smooth muscle cell growth. Methods and Results—HNE, at concentrations of 1.0 and 2.5 μmol/L, significantly stimulated rat aortic smooth muscle cell growth as determined by cell counts, [3H]-thymidine uptake, and incorporation of bromo-deoxyuridine. To characterize the mechanism of HNE-induced mitogenesis, its effect on activation of intracellular growth signaling pathways was examined. Treatment with HNE resulted in activation of extracellular signal-regulated protein kinases ERK1 and ERK2, induction of c-fos and c-jun protein expression, and an increase in transcription factor AP-1 DNA binding activity. In addition, HNE induced expression of platelet-derived growth factor-AA (PDGF-AA) protein, and an anti–PDGF-AA antibody specifically inhibited HNE-mediated DNA synthesis, suggesting that growth factor induction may play a role in HNE-induced vascular smooth muscle cell growth. The role of redox-sensitive mechanisms in this process was further supported by the observation that HNE-induced DNA synthesis and AP-1 activation were inhibited by the antioxidants N-acetylcysteine and pyrrolidine dithiocarbamate. Conclusions—These data demonstrate that HNE, one of several important lipid peroxidation products, induces rat aortic smooth muscle cell growth through redox-sensitive mechanisms and growth factor expression. These observations are consistent with a role for lipid peroxidation products in vascular smooth muscle cell growth in atherogenesis.

Matching Content Categories {📚}

  • Science
  • Education
  • Social Networks

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

hne, google, scholar, crossref, pubmed, rasm, cell, growth, cells, protein, smooth, muscle, effects, activation, lipid, μmoll, vascular, peroxidation, cellular, effect, expression, dna, treated, fig, cardiology, pdgfaa, thiol, treatment, synthesis, mitogenic, human, hours, hydroxynonenal, vsmc, growtharrested, activity, signaling, data, university, circulation, hneinduced, proliferation, events, serum, biol, division, rat, results, role, cfos,

Topics {✒️}

aha/asa scientific statements platelet-derived growth factor-aa anti-pdgf-aa antibody ameliorates peroxidase-labeled anti-brdu antibody american heart association vascular smooth-muscle cells human low-density lipoprotein oxygen-derived free radicals mitogen-activated protein kinases mitogen-activated protein kinase anti–pdgf-aa antibody hne-induced pdgf-aa synthesis [32p]-labeled ap-1 oligonucleotide early signaling events balloon-injured baboon arteries modified low-density lipoproteins 1093/biomethods/bpae038 crossref sharda trichloroacetic acid-precipitable material o6-methylguanine dna methyltransferase nitric oxide-related species supplements download pdf macrophage-rich fatty streaks heart failure stroke platelet-contained growth factors görög pg ap-1-dna binding activity 50 ng/ml tnf-α xanthine/xanthine oxidase metabolism ω6-polyunsaturated fatty acids c-myc mrna expression red ™ aha oxidative stress-induced protein alcohol-induced liver injury c-jun protein translated smooth muscle cells camp-independent mechanisms mediating increased pdgf-aa levels hne stimulated c-fos cellular redox state mitogen-activated kinases c-jun protein expression atherosclerotic lesions coronary atherosclerotic plaques c-fos protein expression ω-6-polyunsaturated fatty acids signal transduction lesion formation hne stimulates c-jun hne-induced mitogenesis involves male sprague-dawley rats

Social Networks {👍}(10)

External Links {🔗}(363)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager

Libraries {📚}

  • Animate.css
  • Dropzone.js
  • Particles.js
  • Swiper
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
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  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Cookielaw

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