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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://www.ahajournals.org/doi/10.1161/01.CIR.101.3.235, but it redirected us to https://www.ahajournals.org/doi/10.1161/01.CIR.101.3.235. The analysis below is for the second page.

Title[redir]:
Modulation of Vascular Inflammation In Vitro and In Vivo by Peroxisome Proliferator–Activated Receptor-γ Activators | Circulation
Description:
Background—Peroxisome proliferator–activated receptor-γ (PPARγ) is expressed in atherosclerotic plaques and in endothelial cells. The possible effects of PPARγ activators on endothelial activation and inflammatory response within the plaque are currently unknown. Methods and Results—We tested the hypothesis that PPARγ activators inhibit vascular cell adhesion molecule (VCAM-1) and intercellular adhesion molecule (ICAM-1) expression in cultured endothelial cells (evaluated by flow cytometry) and homing of monocyte/macrophages to atherosclerotic plaques in vivo. In endothelial cells, the PPARγ agonists troglitazone at 100 μmol/L and 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) at 20 μmol/L markedly attenuated the tumor necrosis factor–induced expression of VCAM-1 and ICAM-1. A significant inhibition of VCAM-1 expression was also evident at 5 and 10 μmol/L 15d-PGJ2 and 20 μmol/L troglitazone. Expression of E-selectin and PECAM-1 was not altered. To confirm the biological relevance of these results, we assessed the effects of troglitazone on monocyte/macrophage homing to atherosclerotic plaques in apoE-deficient mice. A 7-day treatment with troglitazone (400 mg/kg) significantly reduced monocyte/macrophage homing to atherosclerotic plaques (236±77 versus 177±43 macrophages, P=0.03); an even more striking inhibition was found at 3200 mg/kg troglitazone (344±76 versus 172±83 macrophages, P=0.005). Conclusions—PPARγ activators inhibit expression of VCAM-1 and ICAM-1 in activated endothelial cells and significantly reduce monocyte/macrophage homing to atherosclerotic plaques. These findings suggest that PPARγ activators, currently used in treatment of type II diabetes, may have beneficial effects in modulating inflammatory response in atherosclerosis.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 94,026,998 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

pparγ, cells, expression, troglitazone, crossref, endothelial, atherosclerotic, μmoll, pubmed, adhesion, activators, plaques, google, scholar, circulation, vcam, homing, icam, proliferatoractivated, activation, monocytemacrophage, vascular, cell, molecules, human, dpgj, receptor, article, heart, ethy, peroxisome, atherosclerosis, medicine, effects, mice, macrophages, access, view, treatment, macrophage, shown, published, results, inhibit, inhibition, eselectin, significantly, activated, diabetes, study,

Topics {✒️}

peroxisome proliferator–activated receptor-γ peroxisome proliferator-activated receptor-γ peroxisome proliferator-activated receptor peroxisome proliferator-activated receptors aha/asa scientific statements cedars-sinai medical center footnote guest editor american heart association r-phycoerythrin–labeled monoclonal antibodies supplements download pdf tnf-α–induced expression early stages crossref ming-hsun lin heart failure stroke red ™ aha tnf-α 10 ng/ml fitc-labeled monoclonal antibodies main content advertisement discussion references 1 references ppar-γ activation flow-induced pparγ activation orphan nuclear receptors intercellular adhesion molecule smooth muscle cells pretreating apoe-deficient mice activated endothelial cells international journal download pdf inhibit macrophage activation tumor necrosis factor myocardial reperfusion international users arteriosclerosis submit ppar-γ myocardial tissues monocyte/macrophage homing texas heart institute activated peritoneal macrophages coronary heart disease pparα activator fenofibrate wolters kluwer health cardiovascular imaging circulation cardiovascular interventions circulation tnf-α stimulation key link monocyte/macrophage surrogates monocyte/macrophage accumulation human endothelial cells

Social Networks {👍}(10)

External Links {🔗}(203)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager

Libraries {📚}

  • Animate.css
  • Dropzone.js
  • Swiper
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cookielaw

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