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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
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  13. CDN Services

We began analyzing https://www.annualreviews.org/content/journals/10.1146/annurev.nutr.20.1.169, but it redirected us to https://www.annualreviews.org/content/journals/10.1146/annurev.nutr.20.1.169. The analysis below is for the second page.

Title[redir]:
Apolipoprotein B: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation | Annual Reviews
Description:
Apolipoprotein (apo)B circulates in two distinct forms, apoB100 and apoB48. Human liver secretes apoB100, the product of a large mRNA encoding 4536 residues. The small intestine of all mammals secretes apoB48, which arises following C-to-U deamination of a single cytidine base in the nuclear apoB transcript, introducing a translational stop codon. This process, referred to as apoB RNA editing, operates through a multicomponent enzyme complex that contains a single catalytic subunit, apobec-1, in addition to other protein factors that have yet to be cloned. ApoB RNA editing also exhibits stringent cis-acting requirements that include both structural and sequence-specific elements—specifically efficiency elements that flank the minimal cassette, an AU-rich RNA context, and an 11-nucleotide mooring sequence—located in proximity to a suitably positioned (usually upstream) cytidine. C-to-U RNA editing may become unconstrained under circumstances where apobec-1 is overexpressed, in which case multiple cytidines in apoB RNA, as well as in other transcripts, undergo C-to-U editing. ApoB RNA editing is eliminated following targeting of apobec-1, establishing that there is no genetic redundancy in this function. Under physiological circumstances, apoB RNA editing exhibits developmental, hormonal, and nutritional regulation, in some cases related to transcriptional regulation of apobec-1 mRNA. ApoB and the microsomal triglyceride transfer protein (MTP) are essential for the assembly and secretion of apoB-containing lipoproteins. MTP functions by transferring lipid to apoB during its translation and by transporting triglycerides into the endoplasmic reticulum to form apoB-free lipid droplets. These droplets fuse with nascent apoB-containing particles to form mature, very low-density lipoproteins or chylomicrons. In cultured hepatic cells, lipid availability dictates the rate of apoB production. Unlipidated or underlipidated forms of apoB are subjected to presecretory degradation, a process mediated by retrograde transport from the lumen of the endoplasmic reticulum to the cytosol, coupled with multiubquitination and proteasomal degradation. Although control of lipid secretion in vivo is primarily achieved at the level of lipoprotein particle size, regulation of apoB production by presecretory degradation may be relevant in some dyslipidemic states.

Matching Content Categories {📚}

  • Video & Online Content
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Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌟 Strong Traffic: 100k - 200k visitors per month


Based on our best estimate, this website will receive around 100,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

apob, editing, rna, annual, vol, article, apobec, degradation, reviews, protein, lipid, institutional, review, volume, mrna, presecretory, ctou, regulation, contact, usage, content, login, publications, journal, subscribe, nutrition, apolipoprotein, lipoprotein, assembly, publication, info, share, forms, human, secretes, intestine, single, cytidine, process, exhibits, circumstances, related, microsomal, triglyceride, transfer, mtp, secretion, apobcontaining, lipoproteins, endoplasmic,

Topics {✒️}

11-nucleotide mooring sequence—located host-microbial interactions shape au-rich rna context food preferences leann annual reviews news careers contact track usage translational stop codon multicomponent enzyme complex single catalytic subunit case multiple cytidines cultured hepatic cells lipid availability dictates submission editorial principles mammals secretes apob48 lipoprotein particle size mammalian intestine lora nuclear apob transcript apob rna editing single cytidine base low-density lipoproteins presecretory degradation nicholas article preparation discover content rna editing preferences apob rna droplets fuse form mature mrna editing policies contact publications a journal information protein factors transferring lipid protein turnover human health nutrition volume 20 kasum vol gordon vol birch vol hill vol journals a presecretory degradation small intestine lipid secretion grain libraries nascent apob apob production proteasomal degradation

Social Networks {👍}(5)

External Links {🔗}(171)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager

Libraries {📚}

  • Fancybox
  • jQuery
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
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  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Cloudflare
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