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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://www.annualreviews.org/content/journals/10.1146/annurev.genet.33.1.229, but it redirected us to https://www.annualreviews.org/content/journals/10.1146/annurev.genet.33.1.229. The analysis below is for the second page.

Title[redir]:
Mechanisms of mRNA Surveillance in Eukaryotes | Annual Reviews
Description:
▪ Abstract  A conserved mRNA degradation system, referred to as mRNA surveillance, exists in eukaryotic cells to degrade aberrant mRNAs. A defining aspect of aberrant transcripts is that the spatial relationship between the termination codon and specific downstream sequence information has been altered. A key, yet unknown, feature of the mRNA surveillance system is how this spatial relationship is assessed in individual transcripts. Two views have emerged to describe how discrimination between proper and improper termination might occur. In the first view, a surveillance complex assembles onto the mRNA after translation termination, and scans the mRNA in a 3′ to 5′ direction for a limited distance. If specific downstream sequence information is encountered during this scanning, then the surveillance complex targets the transcript for rapid decay. An alternate view suggests that the downstream sequence information influences how translation termination occurs. This view encompasses several ideas including: (a) The architecture of the mRNP can alter the rate of key steps in translation termination; (b) the discrimination between a proper and improper termination occurs via an internal, Upf1-dependent, timing mechanism; and (c) proper termination results in the restructuring of the mRNP to a form that promotes mRNA stability. This proposed model for mRNA surveillance is similar to other systems of kinetic proofreading that monitor the accuracy of other biogenic processes such as translation and spliceosome assembly.

Matching Content Categories {📚}

  • News & Politics
  • Politics
  • Books & Literature

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 91,205,781 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

mrna, termination, annual, surveillance, vol, article, translation, information, view, reviews, institutional, review, volume, downstream, sequence, proper, mrnp, contact, usage, content, login, publications, journal, subscribe, genetics, mechanisms, publication, info, share, system, aberrant, transcripts, spatial, relationship, specific, key, discrimination, improper, complex, decay, occurs, kinetic, proofreading, cited, knowable, magazine, news, charleston, advisor, grain,

Topics {✒️}

annual reviews read annual reviews news careers contact track usage heat-shock proteins evolutionary medicine douglas submission editorial principles donald court vol jeannette whitton vol degrade aberrant mrnas surveillance complex assembles surveillance complex targets alternate view suggests mrna surveillance system promotes mrna stability cited rss feed improper termination occurs translation termination occurs article preparation preferences proper termination results journal information discover content policies contact publications a mrna surveillance improper termination genetics volume 33 craig vol klionsky vol wallace vol journals a aberrant transcripts view encompasses 631–677 regulation mechanisms grain libraries termination codon translation termination mrna biogenesis understand skip eukaryotic cells defining aspect spatial relationship individual transcripts limited distance rapid decay ideas including upf1-dependent timing mechanism proposed model

Social Networks {👍}(5)

External Links {🔗}(165)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager

Libraries {📚}

  • Fancybox
  • jQuery
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Cloudflare
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