
DOI . ORG {
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Title[redir]:
The Inflammasomes and Autoinflammatory Syndromes | Annual Reviews
Description:
Inflammation, a vital response of the immune system to infection and damage to tissues, can be initiated by various germline-encoded innate immune-signaling receptors. Among these, the inflammasomes are critical for activation of the potent proinflammatory interleukin-1 cytokine family. Additionally, inflammasomes can trigger and maintain inflammatory responses aimed toward excess nutrients and the numerous danger signals that appear in a variety of chronic inflammatory diseases. We discuss our understanding of how inflammasomes assemble to trigger caspase-1 activation and subsequent cytokine release, describe how genetic mutations in inflammasome-related genes lead to autoinflammatory syndromes, and review the contribution of inflammasome activation to various pathologies arising from metabolic dysfunction. Insights into the mechanisms that govern inflammasome activation will help in the development of novel therapeutic strategies, not only for managing genetic diseases associated with overactive inflammasomes, but also for treating common metabolic diseases for which effective therapies are currently lacking.
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Keywords {🔍}
annual, inflammasomes, vol, review, article, mechanisms, reviews, activation, nlrp, institutional, disease, volume, diseases, contact, usage, content, login, publications, journal, subscribe, pathology, autoinflammatory, syndromes, publication, info, share, response, immune, cytokine, trigger, inflammatory, genetic, inflammasome, metabolic, insights, cited, cancer, impact, knowable, magazine, news, charleston, advisor, grain, copyright, cookies, track, preferencesi, understand, skip,
Topics {✒️}
annual reviews read inflammasome-related genes lead annual reviews subsequent cytokine release chronic inflammatory diseases news careers contact clinical impact track usage dominic de nardo4 numerous danger signals pierre-yves desprez resistance sreya bagchi submission editorial principles managing genetic diseases judith campisi vol disease relevance marcia govern inflammasome activation cited rss feed trigger caspase-1 activation preferences 2015 review article article preparation autoinflammatory syndromes discover content immune system policies contact inflammasome activation publications a journal information disease volume 10 metabolic dysfunction related articles journals a genetic mutations grain libraries sinclair vol engleman vol friedman vol croce vol understand skip eicke latz4 1146/annurev-pathol-012414-040431 excess nutrients pathologies arising therapeutic strategies effective therapies secretory phenotype dark side ana krtolica 99–118 mammalian sirtuins
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