
DOI . ORG {
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Title[redir]:
Mitochondrial tRNA Import and Its Consequences for Mitochondrial Translation | Annual Reviews
Description:
The mitochondrial genomes of most eukaryotes lack a variable number of tRNA genes. This lack is compensated for by import of a small fraction of the corresponding cytosolic tRNAs. There are two broad mechanisms for the import of tRNAs into mitochondria. In the first one, the tRNA is coimported together with a mitochondrial precursor protein along the protein import pathway. It applies to the yeast tRNALys and has been elucidated in great detail. In the second more vaguely defined mechanism, which is mainly found in plants and protozoa, tRNAs are directly imported independent of cytosolic factors. However, results in plants indicate that direct import of tRNAs may nevertheless require some components of the protein import machinery. All imported tRNAs in all systems are of the eukaryotic type but need to be functionally integrated into the mitochondrial translation system of bacterial descent. For some tRNAs, this is not trivial and requires unique evolutionary adaptations.
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Keywords {π}
mitochondrial, import, annual, vol, trnas, protein, article, review, reviews, institutional, volume, trna, translation, contact, usage, content, login, publications, journal, subscribe, biochemistry, publication, info, share, lack, cytosolic, plants, imported, system, cited, knowable, magazine, news, charleston, advisor, grain, copyright, cookies, track, preferencesi, understand, skip, register, cart, information, give, home, consequences, andrΓ©, schneider,
Topics {βοΈ}
receptor-generated signals alfred annual reviews read annual reviews mitochondrial translation system news careers contact mitochondrial precursor protein mitochondrial protein import track usage vaguely defined mechanism aaron ciechanover vol submission editorial principles aminoacyl-trna synthetase protein import pathway protein import machinery directly imported independent cited rss feed article preparation preferences organellar translation discover content mitochondrial genomes mitochondrial biogenesis policies contact publications a journal information 425β479 protein misfolding dobson vol anderson vol tsien vol gilman vol trna genes biochemistry volume 80 journals a direct import grain libraries understand skip 1146/annurev-biochem-060109-092838 variable number small fraction broad mechanisms yeast trnalys great detail cytosolic factors eukaryotic type functionally integrated bacterial descent 5s rrna functional amyloid related articles imported trnas
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