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Title[redir]:
Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment | Journal of Virology
Description:
ABSTRACT Chronic viral infections often result in ineffective CD8 T-cell responses due to functional exhaustion or physical deletion of virus-specific T cells. However, how persisting virus impacts various CD8 T-cell effector functions and influences ...
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Keywords {🔍}
cells, infection, lcmv, tcell, google, scholar, chronic, pubmed, crossref, science, viral, web, virus, functional, mice, fig, responses, dbgp, exhaustion, antigen, ifnγ, loss, function, production, tnfα, populations, data, shown, day, infections, acute, virusspecific, results, load, effector, epitopes, cytotoxic, liver, deletion, similar, lymphocytes, tetramerpositive, ahmed, human, observed, memory, functions, microbiology, infected, levels,
Topics {✒️}
t-cell receptor complex epitope-specific t-cell populations gamma-herpesvirus-infected cd4-deficient mice virus-specific t-cell responses subscribers journal home increased cd95/fas-induced apoptosis cd8 t-cell-produced il-2 db/gp276-specific populations induced t-cell populations equally ice-cold tenbroeck homogenizer studying t-cell responses social media facebook cd8 t-cell populations cytotoxic-t-cell responses cd8 t-cell responses privacy policy sets functional t-cell populations db/gp276 tetramer-positive populations reduce t-cell stimulation clinical microbiology journal microbiology american society cd8 t-cell response cd8 t-cell functions individual t-cell population human virus-specific cd8 cd8 t-cell exhaustion frequent t-cell stimulation db/gp33 tetramer stain h-2db-restricted gp276-286 cd8 t-cell function persistent t-cell stimulation htlv-1 tax11-19-specific cd8 h-2kb-restricted gp34-43 cd8 t-cell dysfunction t-cell functional impairment kb/gp34 tetramer-positive cells cd8 t-cell epitopes magnetic-activated cell sorter cd8 t-cell dynamics privacy policy lcmv t-cell epitopes h-2db-restricted gp33-41 mhc-peptide complex stability kb/gp34-specific populations major histocompatibility complex dysfunctional epstein-barr virus h-2db-restricted np396-404 individual epitope-specific populations tnfr1-mediated cytotoxic pathways kb/gp34-specific cd8
Questions {❓}
- Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
- Dressed to kill?
- How can this data be reconciled with the diverse reports from the human and primate systems?
- Why do functional responses disappear during chronic viral infections?
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